Age‐related changes in total protein and collagen metabolism in rat liver
Peter K. Mays, Robin McAnulty, Geoffrey J. Laurent – 1 December 1991 – Liver collagen levels are determined by a balance between synthesis and degradation, processes known to have rapid rates in growing animals. We report age‐related changes in liver collagen synthesis and degradation rates, as well as protein synthesis rates, in rats at five ages from 1 to 24 mo. Fractional collagen synthesis rates were determined after injection of [14C]proline with a flooding dose of unlabeled proline and its incorporation as hydroxy‐[14C]proline into proteins.