Colchicine clearance is impaired in alcoholic cirrhosis

Jonathan A. Leighton, Michael K. Bay, Alma L. Maldonado, Steven Schenker, K. Vincent Speeg – 1 December 1991 – Colchicine may have benefit in primary biliary cirrhosis and alcoholic liver disease. It is currently used in patients with impaired liver function, yet little is known about its elimination in such patients. Colchicine clearance in the rat is significantly impaired in various models of liver disease. To study this in human beings, colchicine pharmacokinetics were compared in normal subjects and patients with alcoholic cirrhosis.

Beneficial effect of pharmacological modulation of the GABAA‐benzodiazepine receptor on hepatic encephalopathy in the rat: Comparison with uremic encephalopathy

Petra Steindl, Andreas Püspök, Wilfred Druml, Peter Ferenci – 1 December 1991 – Hepatic encephalopathy is ameliorated by drugs acting on the central GABAA‐benzodiazepine receptor complex.

Cell cycle–dependent uptake of putrescine and its importance in regulating cell cycle phase transition in cultured adult mouse hepatocytes

Roger L. Martin, Kenneth F. Ilett, Rodney F. Minchin – 1 December 1991 – Previous studies in which investigators have induced the rate of polyamine uptake in vitro have used either inhibitors of polyamine biosynthesis or growth factors that induce cell proliferation. Recently, however, we have described the induction of putrescine uptake in cultured adult mouse hepatocytes and have shown that uptake is independent of both intracellular polyamine levels and proliferation.

Age‐related changes in total protein and collagen metabolism in rat liver

Peter K. Mays, Robin McAnulty, Geoffrey J. Laurent – 1 December 1991 – Liver collagen levels are determined by a balance between synthesis and degradation, processes known to have rapid rates in growing animals. We report age‐related changes in liver collagen synthesis and degradation rates, as well as protein synthesis rates, in rats at five ages from 1 to 24 mo. Fractional collagen synthesis rates were determined after injection of [14C]proline with a flooding dose of unlabeled proline and its incorporation as hydroxy‐[14C]proline into proteins.

Detection of hepatitis C virus antibodies and hepatitis C virus RNA in patients with alcoholic liver disease

Shuhei Nishiguchi, Tetsuo Kuroki, Tsuneo Yabusako, Shuichi Seki, Kenzo Kobayashi, Takeyuki Monna, Shuzo Otani, Masami Sakurai, Toshio Shikata, Sukeo Yamamoto – 1 December 1991 – The relationship between alcoholic liver disease and hepatitis C virus was studied in 80 patients by searching for hepatitis C virus RNA with the polymerase chain reaction and by measuring hepatitis C virus antibodies.

Serum factor from patients with cirrhosis and hepatocellular carcinoma enhances production of prostaglandin E2 by U937 cells

Hiroaki Iwamoto, Shigeru Sakamoto, Hajime Nawata – 1 December 1991 – The effect of serum from patients with cirrhosis and hepatocellular carcinoma on the release of prostaglandin E2 by the human histiocytic lymphoma cell line U937 was investigated to explain the mechanism underlying the immunoregulatory dysfunction of monocytes in cirrhosis and hepatocellular carcinoma.

IgG is associated with the asialoglycoprotein receptor in the human liver

Takashi Inamoto, William R. Brown – 1 December 1991 – Various pathophysiological relationships between IgA and the asialoglycoprotein receptor on hepatocytes have been proposed. As a step toward defining these relationships, we purified the receptor from human livers by means of p‐aminophenyl β‐D‐thiogalactopyranoside‐agarose affinity chromatography. Unexpectedly, we found the asialoglycoprotein receptor to be associated specifically with IgG.

Subscribe to