Bilirubin diglucuronide transport by rat liver canalicular membrane vesicles: Stimulation by bicarbonate ion
Yukihiko Adachi, Hiroaki Kobayashi, Yoshiaki Kurumi, Mika Shouji, Motokazu Kitano, Toshio Yamamoto – 1 December 1991 – The purpose of this study was to provide further insight into the mechanism of bilirubin diglucuronide excretion through the hepatocyte canalicular membrane by investigating the uptake of (3H)bilirubin diglucuronide by purified canalicular membrane vesicles of rat liver. The uptake was analyzed by a rapid filtration technique. The difference between vesicle‐associated (3H)bilirubin diglucuronide at 37° C and at 0° C during the initial 1 min was regarded as uptake.