Steven I. Shedlofsky, Niel C. Hoglen, Larry E. Rodman, Ron Honchel, Farrel R. Robinson, Alice T. Swim, Craig J. McClain, Larry W. Robertson – 1 December 1991 – To determine whether the cytokine tumor necrosis factor/cachectin might be a mediator of hepatotoxicity seen after exposure to polyhalogenated aromatic hydrocarbons, rats treated with a single dose of 3,3′,4,4′‐tetrabromobiphenyl (150 μmol/kg intraperitoneally) or corn oil vehicle were studied. The 3,3′,4,4′‐tetrabromobiphenyl caused the expected anorexia, alterations in organ weights and changes in cytochromes P‐450 over 21 days.

Albert D. Min, Tobias Goeser, Rui Liu, Celeste G. Campbell, Phyllis M. Novikoff, Allan W. Wolkoff – 1 December 1991 – In previous studies, we identified a 55 kD organic anion–binding protein in liver cell sinusoidal plasma membrane subfractions. Other investigators identified another 55 kD bromosulfophthalein/bilirubin binding protein on the surface of rat hepatocytes and HepG2 cells and suggested that this protein served as a transporter for these ligands.

Yukihiko Adachi, Hiroaki Kobayashi, Yoshiaki Kurumi, Mika Shouji, Motokazu Kitano, Toshio Yamamoto – 1 December 1991 – The purpose of this study was to provide further insight into the mechanism of bilirubin diglucuronide excretion through the hepatocyte canalicular membrane by investigating the uptake of (3H)bilirubin diglucuronide by purified canalicular membrane vesicles of rat liver. The uptake was analyzed by a rapid filtration technique. The difference between vesicle‐associated (3H)bilirubin diglucuronide at 37° C and at 0° C during the initial 1 min was regarded as uptake.

J. Fred Nagelkerke, Bob van de Water, Irene M. Twiss, J. Paul Zoetewey, Hans J. G. M. de Bont, Peter Dogterom, Gerard J. Mulder – 1 December 1991 – The secretion of very‐low‐density lipoprotein from hepatocytes proceeds through the microtubules. In this study, the role of glutathione in the maintenance of intact microtubules and the secretion of very‐low‐density lipoprotein has been investigated.

Jorge J. Gumucio, Michael P. Jones, Douglas M. Heuman – 1 December 1991 – An 88‐yr‐old man carrying the tentative diagnosis of Alzheimer's disease had a documented history of ingesting 20 to 30 eggs/day for approximately 15 yr. His psychiatrist characterized his eating habits as a compulsive disorder:“Eating these eggs ruins my life, but I can't help it.” He is in excellent health. His weight is constant at 82 to 86 kg (height 1.87 m). Apparently, he had a mild episode of angina. Otherwise, no significant history of stroke, heart disease or gallbladder disease was seen.

Stephen Crane Hauser – 1 December 1991

Johnson Y. N. Lau, Vincent G. Bain, Nikolai V. Naoumov, Heather M. Smith, Graeme J. M. Alexander, Roger Williams – 1 December 1991 – Interferon‐α has been shown recently to selectively enhance hepatocyte expression of HBsAg/pre‐S2 in chronic hepatitis B virus infection in a way that may enhance immune recognition.

Christian Moesch, Denis Sautereau, Franclois Cessot, Pascal Berry, Marcelle Mounier, Alain Gainant, Bernard Pillegand – 1 December 1991 – The deposits obstructing 12 biliary endoprostheses were examined by scanning electron microscopy and analyzed quantitatively by Fourier transform infrared spectroscopy. Calcium palmitate and bilirubinate associated with proteins were found in all the deposits. Apart from the small amount of cholesterol, this composition closely resembled that of brown pigment gallstones and suggested an infectious cause.

Russell E. Cowan, Barry T. Jackson, Stephen L. Grainger, Richard P. H. Thompson – 1 December 1991 – The cause of postoperative liver dysfunction is often unclear, but a decrease in liver blood flow during anesthesia and/or major surgery may be important. Plasma half‐life and clearance of indocyanine green were therefore measured in 42 patients before, during and after anesthesia and abdominal surgery. In 13 patients, liver blood flow was also estimated from indocyanine green extraction using hepatic vein catheterization.

Peter D. Siersema, René P. van Helvoirt, Diane A. M. Ketelaars, Maud I. Cleton, Wim C. de Bruijn, J. H. Paul Wilson, Henk G. van Eijk – 1 December 1991 – Hexachlorobenzene‐induced porphyria is iron dependent and characterized by the decreased activity of uroporphyrinogen decarboxylase and the accumulation of porphyrins in the liver. To examine the relationship between iron and porphyrins in liver tissue, we performed a biochemical and morphological (histological, ultrastructural and morphometrical) study in the livers of C57BL/10 mice.