Reframing the approach to patients with hepatocellular carcinoma: Longitudinal assessment with hazard associated with liver transplantation for HCC (HALTHCC) improves ablate and wait strategy

Daniel J. Firl, Shoko Kimura, John McVey, Koji Hashimoto, Heidi Yeh, Charles M. Miller, James F. Markmann, Kazunari Sasaki, Federico N. Aucejo – 31 March 2018 – Patients with hepatocellular carcinoma (HCC) are screened at presentation for appropriateness of liver transplantation (LT) using morphometric criteria, which poorly specifies risk. Morphology is the crux of measuring tumor response to locoregional therapy (LRT) using modified Response Evaluation Criteria in Solid Tumors (mRECIST).

Expanding the donor pool: Donation after circulatory death and living liver donation do not compromise the results of liver transplantation

Dagmar Kollmann, Gonzalo Sapisochin, Nicolas Goldaracena, Bettina E. Hansen, Ramraj Rajakumar, Nazia Selzner, Mamatha Bhat, Stuart McCluskey, Mark S. Cattral, Paul D. Greig, Les Lilly, Ian D. McGilvray, Anand Ghanekar, David R. Grant, Markus Selzner – 31 March 2018 – Because of the shortfall between the number of patients listed for liver transplantation (LT) and the available grafts, strategies to expand the donor pool have been developed.

Receipt of a pediatric liver offer as the first offer reduces waitlist mortality for adult women

Jin Ge, Richard Gilroy, Jennifer C. Lai – 31 March 2018 – In liver transplantation, adults with small stature have a greater susceptibility to waitlist mortality. This may explain the persistent waitlist mortality disparity that exists for women. We hypothesized that women who receive early offers of pediatric donor livers have improved waitlist survival, and that preferentially offering these organs to women mitigates this sex‐based disparity. We analyzed donor liver offers from 2010 to 2014.

Biliary Atresia: Clinical and Research Challenges for the Twenty‐First Century

Jorge A. Bezerra, Rebecca G. Wells, Cara L. Mack, Saul J. Karpen, Jay H. Hoofnagle, Edward Doo, Ronald J. Sokol – 31 March 2018 – Biliary atresia (BA) is a fibroinflammatory disease of the intrahepatic and extrahepatic biliary tree. Surgical hepatic portoenterostomy (HPE) may restore bile drainage, but progression of the intrahepatic disease results in complications of portal hypertension and advanced cirrhosis in most children.

Liver Angiopoietin‐2 Is a Key Predictor of DeNovo or Recurrent Hepatocellular Cancer After Hepatitis CVirus Direct‐Acting Antivirals

Francesca Faillaci, Luca Marzi, Rosina Critelli, Fabiola Milosa, Filippo Schepis, Elena Turola, Silvia Andreani, Gabriele Vandelli, Veronica Bernabucci, Barbara Lei, Federica D'Ambrosio, Laura Bristot, Luisa Cavalletto, Liliana Chemello, Pamela Sighinolfi, Paola Manni, Antonino Maiorana, Cristian Caporali, Marcello Bianchini, Maria Marsico, Laura Turco, Nicola de Maria, Mariagrazia Del Buono, Paola Todesca, Luca di Lena, Dante Romagnoli, Paolo Magistri, Fabrizio di Benedetto, Savino Bruno, Gloria Taliani, Gianluigi Giannelli, Maria‐Luz Martinez‐Chantar, Erica Villa – 31 March 2018 – Recent

Clinical Course of Hepatic Artery Thrombosis After Living Donor Liver Transplantation Using the Right Lobe

Ho Joong Choi, Dong Goo Kim, Yumi Kim, Bong Jun Kwak, Jae Hyun Han, Tae Ho Hong, Young Kyoung You – 31 March 2018 – Hepatic artery thrombosis (HAT) can result in biliary tree necrosis and graft loss, necessitating retransplantation. The most effective treatment approach is still controversial. This study was performed to review the outcomes of HAT after living donor liver transplantation (LDLT) and to clarify the feasibility of different strategies. From May 1996 to August 2017, LDLT using the right lobe was performed in 827 adult patients in our center.

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