Role of Sarcopenia in Nonalcoholic Fatty Liver Disease: Definition Is Crucially Important
Tao‐Chun Peng – 31 March 2018
Expanding the donor pool: Donation after circulatory death and living liver donation do not compromise the results of liver transplantation
Dagmar Kollmann, Gonzalo Sapisochin, Nicolas Goldaracena, Bettina E. Hansen, Ramraj Rajakumar, Nazia Selzner, Mamatha Bhat, Stuart McCluskey, Mark S. Cattral, Paul D. Greig, Les Lilly, Ian D. McGilvray, Anand Ghanekar, David R. Grant, Markus Selzner – 31 March 2018 – Because of the shortfall between the number of patients listed for liver transplantation (LT) and the available grafts, strategies to expand the donor pool have been developed.
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Min Suk Chae, Sang Hyun Hong – 31 March 2018
Reframing the approach to patients with hepatocellular carcinoma: Longitudinal assessment with hazard associated with liver transplantation for HCC (HALTHCC) improves ablate and wait strategy
Daniel J. Firl, Shoko Kimura, John McVey, Koji Hashimoto, Heidi Yeh, Charles M. Miller, James F. Markmann, Kazunari Sasaki, Federico N. Aucejo – 31 March 2018 – Patients with hepatocellular carcinoma (HCC) are screened at presentation for appropriateness of liver transplantation (LT) using morphometric criteria, which poorly specifies risk. Morphology is the crux of measuring tumor response to locoregional therapy (LRT) using modified Response Evaluation Criteria in Solid Tumors (mRECIST).
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Rahima A. Bhanji, Kymberly D. Watt – 31 March 2018
Nonalcoholic fatty liver disease: Is it time for combination treatment and a diabetes‐like approach?
Stergios A. Polyzos, Jannis Kountouras, Sotiris Anastasiadis, Michael Doulberis, Panagiotis Katsinelos – 30 March 2018
Hepatocyte microvesicle levels improve prediction of mortality in patients with cirrhosis
Audrey Payancé, Gilberto Silva‐Junior, Julien Bissonnette, Marion Tanguy, Blandine Pasquet, Cristina Levi, Olivier Roux, Ouardia Nekachtali, Anna Baiges, Virginia Hernández‐Gea, Cédric Laouénan, Didier Lebrec, Miguel Albuquerque, Valérie Paradis, Richard Moreau, Dominique Valla, François Durand, Chantal M. Boulanger, Juan‐Carlos Garcia‐Pagan, Pierre‐Emmanuel Rautou – 30 March 2018 – Microvesicles (MVs) are extracellular vesicles released by cells following activation or apoptosis. Some MV subpopulations augment with cirrhosis severity and contribute to portal hypertension.
Loss of PDK4 switches the hepatic NF‐κB/TNF pathway from pro‐survival to pro‐apoptosis
Jianguo Wu, Yulan Zhao, Young‐Ki Park, Ji‐Young Lee, Ling Gao, Jiajun Zhao, Li Wang – 30 March 2018 – It has been established that nuclear factor kappa‐light‐chain‐enhancer of activated B cells (NF‐κB) members promote survival by upregulating antiapoptotic genes and that genetic and pharmacological inhibition of NF‐κB is required for tumor necrosis factor (TNF)‐induced hepatocyte apoptosis. In this study, we demonstrate that this pro‐survival pathway is switched to pro‐apoptosis under pyruvate dehydrogenase kinase 4 (PDK4)‐deficient conditions.
What's cold got to do with it? Cold‐induced thermogenesis and microbiome modification may be regulated by bile acid physiology
Nisreen Soufi, Rohit Kohli – 30 March 2018
Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T‐cell infiltrate
Catherine A. Chapin, Thomas Burn, Tomas Meijome, Kathleen M. Loomes, Hector Melin‐Aldana, Portia A Kreiger, Peter F. Whitington, Edward M. Behrens, Estella M. Alonso – 30 March 2018 – The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence suggests that aberrant immune system activation may play a role. We hypothesized that indeterminate PALF cases would exhibit a unique pattern of hepatic inflammation. This was a retrospective and prospective study of PALF cases due to indeterminate (iPALF), autoimmune hepatitis, or known diagnosis (dPALF) etiology.