Deqiang Zhang, Xin Tong, Bradley B. Nelson, Ethan Jin, Julian Sit, Nicholas Charney, Meichan Yang, M. Bishr Omary, Lei Yin – 13 March 2018 – Alcohol liver disease (ALD) is one of the major chronic liver diseases worldwide, ranging from fatty liver, alcoholic hepatitis, cirrhosis, and potentially, hepatocellular carcinoma. Epidemiological studies suggest a potential link between ALD and impaired circadian rhythms, but the role of hepatic circadian proteins in the pathogenesis of ALD remains unknown.

James Fung, Ka‐Shing Cheung, Danny Ka‐Ho Wong, Lung‐Yi Mak, Wai‐Pan To, Wai‐Kay Seto, Ching‐Lung Lai, Man‐Fung Yuen – 13 March 2018 – The significance of hepatitis B e‐antigen (HBeAg) seroclearance (ESC) in the long term is not well defined. The current study aimed to determine the clinical outcomes, the factors and predictive scores for hepatocellular carcinoma (HCC), and hepatitis B surface antigen (HBsAg) seroclearance of a large cohort of patients undergoing ESC. Patients with documented ESC were followed up 3‐ to 6‐monthly.

Nao Nishida, Masaya Sugiyama, Hiromi Sawai, Sohji Nishina, Aiko Sakai, Jun Ohashi, Seik‐Soon Khor, Keisuke Kakisaka, Takayo Tsuchiura, Keisuke Hino, Ryo Sumazaki, Yasuhiro Takikawa, Kazumoto Murata, Tatsuo Kanda, Osamu Yokosuka, Katsushi Tokunaga, Masashi Mizokami – 13 March 2018 – Approximately 5‐10% of individuals who are vaccinated with a hepatitis B (HB) vaccine designed based on the hepatitis B virus (HBV) genotype C fail to acquire protective levels of antibodies.

Seidai Wada, Etsuro Hatano, Tomoaki Yoh, Naohiko Nakamura, Yukihiro Okuda, Masayuki Okuno, Yosuke Kasai, Keiko Iwaisako, Satoru Seo, Kojiro Taura, Shinji Uemoto – 10 March 2018 – Ischemia/reperfusion injury (IRI) is one of the main causes of liver dysfunction after liver surgery. Involvement of endoplasmic reticulum (ER) stress in various diseases has been demonstrated, and CAAT/enhancer binding protein–homologous protein (CHOP) is a transcriptional regulator that is induced by ER stress. It is also a key regulator of ER stress‐mediated apoptosis.

Stefan Gilg, Ernesto Sparrelid, Lars Saraste, Greg Nowak, Staffan Wahlin, Cecilia Strömberg, Lars Lundell, Bengt Isaksson – 8 March 2018 – Posthepatectomy liver failure (PHLF) represents the single most important cause of postoperative mortality after major liver resection, yet no effective treatment option is available. Extracorporeal liver support devices might be helpful, but systematic studies are lacking. Accordingly, we aimed to assess the safety and feasibility of the Molecular Adsorbent Recirculating System (MARS) in patients with PHLF.

The webinar will focus on the best practices and the underlying evidence in terms of surgical management of the portal hypertensive patient. A practical approach will be outlined whereby patient risk, assessment, and management will be discussed. This is an essential and daily part  of practice for hepatologists and this  webinar will update and educate as to current management.Brett E. Fortune (Moderator) Brett E. Fortune, MD, MSc, is a transplant hepatologist who works at New York Presbyterian/Weill Cornell for the Center for Liver Disease and Transplantation. Dr.

Marina Serper – 7 March 2018

Annie J. Kruger, Bryan C. Fuchs, Ricard Masia, Jacinta A. Holmes, Shadi Salloum, Mozhdeh Sojoodi, Diego S. Ferreira, Stephanie M. Rutledge, Peter Caravan, Nadia Alatrakchi, Pam Vig, Eric Lefebvre, Raymond T. Chung – 7 March 2018 – Nonalcoholic steatohepatitis (NASH) is a progressive liver disease projected to become the leading cause of cirrhosis and liver transplantation in the next decade. Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage trafficking and is under clinical investigation for the treatment of human NASH fibrosis.

David D. Lee, Kristopher P. Croome, Kaitlyn R. Musto, Jose Melendez, Ghassan Tranesh, Raouf Nakhleh, C. Burcin Taner, Justin H. Nguyen, Tushar Patel, Denise M. Harnois – 7 March 2018 – Although hepatocellular carcinoma (HCC) has become a common indication for liver transplantation (LT), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular carcinoma–cholangiocarcinoma (cHCC‐CCA) are historically contraindicated due to their aggressive behavior.

Archna Koul – 7 March 2018