DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1

Hao Zhang, Yanqiu Zhang, Xiaoyun Zhu, Chen Chen, Chao Zhang, Yuanzheng Xia, Yucheng Zhao, Ourania Andrisani, Lingyi Kong – 3 October 2018 – In hepatocellular carcinoma (HCC), dysregulated expression of DDX5 (DEAD box protein 5) and impaired autophagy have been reported separately. However, the relationship between them has not been explored. Here we present evidence to show that, by interacting with autophagic receptor p62, DDX5 promotes autophagy and suppresses tumorigenesis.

Down‐regulation of TROP‐2 Predicts Poor Prognosis of Hepatocellular Carcinoma Patients

Sarah T. K. Sin, Yan Li, Ming Liu, Yun‐Fei Yuan, Stephanie Ma, Xin‐Yuan Guan – 2 October 2018 – Hepatocellular carcinoma (HCC) is one of the most common and lethal cancer types worldwide, especially in Asian countries. Genetic alterations, including hyperactivation of oncogenes and loss of expression of tumor suppressor genes, greatly contribute to the initiation and progression of HCC. Here we report that down‐regulation of trophoblast cell surface antigen 2 (TROP‐2) was frequently detected in HCC.

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