The “Skinny” on Assessment and Utilization of Steatotic Liver Grafts: A Systematic Review

Kristopher P. Croome, David D. Lee, C. Burcin Taner – 28 February 2019 – The frequency at which steatotic deceased donor liver grafts are encountered will likely continue to increase. Utilization of liver grafts with moderate‐to‐severe steatosis for liver transplantation (LT) has been previously shown to be associated with increased rates of primary nonfunction and decreased recipient survival. In order to better inform clinical decision making and guide future research, critical evaluation of the literature on donor liver steatosis and posttransplantation outcome is needed.

Manipulation of Lipid Metabolism During Normothermic Machine Perfusion: Effect of Defatting Therapies on Donor Liver Functional Recovery

Yuri L. Boteon, Joseph Attard, Amanda P. C. S. Boteon, Lorraine Wallace, Gary Reynolds, Stefan Hubscher, Darius F. Mirza, Hynek Mergental, Ricky H. Bhogal, Simon C. Afford – 28 February 2019 – Strategies to increase the use of steatotic donor livers are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human livers during ex situ normothermic machine perfusion to promote defatting and improve the functional recovery of the organs.

Hepatology Highlights

Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Tasha B. Kulai, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole T. Shen, Robert S. Brown, Petra Hirsova, Xu Xu, Hayley T. Nicholls, Joseph F. Pisa, Zaid H. Tafesh, Brett E. Fortune, Vikas Gupta, Enis Kostallari, Nicholas Russo, Arun B. Jesudian – 27 February 2019

Hepatology Highlights

Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Tasha B. Kulai, Hirsh D. Trivedi, Daryl T.Y. Lau, Nicole T. Shen, Robert S. Brown, Petra Hirsova, Xu Xu, Hayley T. Nicholls, Joseph F. Pisa, Zaid H. Tafesh, Brett E. Fortune, Vikas Gupta, Enis Kostallari, Nicholas Russo, Arun B. Jesudian – 27 February 2019

Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in Liver Cancer

Qinchuan Wu, Wuhua Zhou, Shengyong Yin, Yuan Zhou, Tianchi Chen, Junjie Qian, Rong Su, Liangjie Hong, Haohao Lu, Feng Zhang, Haiyang Xie, Lin Zhou, Shusen Zheng – 27 February 2019 – Tumor‐associated macrophages (TAMs) are recognized as antitumor suppressors, but how TAMs behave in the hypoxic environment of hepatocellular carcinoma (HCC) remains unclear. Here, we demonstrated that hypoxia inducible factor 1α induced increased expression of triggering receptor expressed on myeloid cells‐1 (TREM‐1) in TAMs, resulting in immunosuppression.

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