Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2–/– mice and human cholangiocarcinoma tumorigenesis
Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Walker Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Vik Meadows, Heather Francis – 30 March 2018 – Primary sclerosing cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) histamine levels increase and mast cells (MCs) infiltrate during PSC and CCA.