Jorge A. Bezerra, Rebecca G. Wells, Cara L. Mack, Saul J. Karpen, Jay H. Hoofnagle, Edward Doo, Ronald J. Sokol – 31 March 2018 – Biliary atresia (BA) is a fibroinflammatory disease of the intrahepatic and extrahepatic biliary tree. Surgical hepatic portoenterostomy (HPE) may restore bile drainage, but progression of the intrahepatic disease results in complications of portal hypertension and advanced cirrhosis in most children.

Nisreen Soufi, Rohit Kohli – 30 March 2018

Fu‐Shan Xue, Ya‐Yang Liu, Qing Liu – 30 March 2018

Cristina Ripoll – 30 March 2018

Lindsey Kennedy, Laura Hargrove, Jennifer Demieville, Walker Karstens, Hannah Jones, Sharon DeMorrow, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Gianfranco Alpini, Steven Smith, Austin Akers, Vik Meadows, Heather Francis – 30 March 2018 – Primary sclerosing cholangitis (PSC) patients are at risk of developing cholangiocarcinoma (CCA). We have shown that (1) histamine increases biliary hyperplasia through H1/H2 histamine receptors (HRs) and (2) histamine levels increase and mast cells (MCs) infiltrate during PSC and CCA.

Yutaka Kurebayashi, Hidenori Ojima, Hanako Tsujikawa, Naoto Kubota, Junki Maehara, Yuta Abe, Minoru Kitago, Masahiro Shinoda, Yuko Kitagawa, Michiie Sakamoto – 30 March 2018 – Immune cells constitute an important element of tumor tissue. Accumulating evidence indicates their clinicopathological significance in predicting prognosis and therapeutic efficacy. Nonetheless, the combinations of immune cells forming the immune microenvironment and their association with histological findings remain largely unknown.

Zobair M. Younossi – 30 March 2018

Jonathan G. Stine, Dmitri Bezinover, Zakiyah Kadry – 30 March 2018

Laura N. Bull, Ludmila Pawlikowska, Sandra Strautnieks, Irena Jankowska, Piotr Czubkowski, Jennifer L. Dodge, Karan Emerick, Catherine Wanty, Sami Wali, Samra Blanchard, Florence Lacaille, Jane A. Byrne, Albertien M. van Eerde, Kaija‐Leena Kolho, Roderick Houwen, Steven Lobritto, Vera Hupertz, Patricia McClean, Giorgina Mieli‐Vergani, Etienne Sokal, Philip Rosenthal, Peter F. Whitington, Joanna Pawlowska, Richard J.

Catherine A. Chapin, Thomas Burn, Tomas Meijome, Kathleen M. Loomes, Hector Melin‐Aldana, Portia A Kreiger, Peter F. Whitington, Edward M. Behrens, Estella M. Alonso – 30 March 2018 – The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence suggests that aberrant immune system activation may play a role. We hypothesized that indeterminate PALF cases would exhibit a unique pattern of hepatic inflammation. This was a retrospective and prospective study of PALF cases due to indeterminate (iPALF), autoimmune hepatitis, or known diagnosis (dPALF) etiology.