Cost‐effectiveness of antiviral treatment after resection in hepatitis B virus–related hepatocellular carcinoma patients with compensated cirrhosis

Li Xie, Juan Yin, Ruyi Xia, Guihua Zhuang – 7 April 2018 – Hepatocellular carcinoma (HCC) imposes a heavy disease burden on China due to its high morbidity and mortality. China accounts for about 50% of the total new cases and deaths worldwide. Most cases are related to hepatitis B virus (HBV) infection and are associated with cirrhosis at diagnosis. Antiviral treatment with nucleos(t)ide analogues (NAs) after resection in HBV‐related HCC can reduce recurrence and improve survival. Such treatment is in fact recommended by Chinese guidelines.

Disruption of Renal Arginine Metabolism Promotes Kidney Injury in Hepatorenal Syndrome in Mice

Zoltan V. Varga, Katalin Erdelyi, Janos Paloczi, Resat Cinar, Zsuzsanna K. Zsengeller, Tony Jourdan, Csaba Matyas, Balazs Tamas Nemeth, Adrien Guillot, Xiaogang Xiang, Adam Mehal, György Haskó, Isaac E. Stillman, Seymour Rosen, Bin Gao, George Kunos, Pal Pacher – 6 April 2018 – Tubular dysfunction is an important feature of renal injury in hepatorenal syndrome (HRS) in patients with end‐stage liver disease. The pathogenesis of kidney injury in HRS is elusive, and there are no clinically relevant rodent models of HRS.

A novel multimarker assay for the phenotypic profiling of circulating tumor cells in hepatocellular carcinoma

Colin M. Court, Shuang Hou, Paul Winograd, Nicholas H. Segel, Qingyu Wilda Li, Yazhen Zhu, Saeed Sadeghi, Richard S. Finn, Ekambaram Ganapathy, Min Song, Samuel W. French, Bita V. Naini, Shonan Sho, Fady M. Kaldas, Ronald W. Busuttil, James S. Tomlinson, Hsian‐Rong Tseng, Vatche G. Agopian – 6 April 2018 – Current clinicopathologic staging systems and serum biomarkers poorly discriminate tumor biology in hepatocellular carcinoma (HCC), with high recurrence rates following curative‐intent surgical resection and liver transplantation (LT).

SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3‐9 homolog 1 and SET domain containing 1A histone methyltransferases

Ji‐Hua Ren, Jie‐Li Hu, Sheng‐Tao Cheng, Hai‐Bo Yu, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong‐Feng Yang, Ying Huang, Yi Liu, Wei‐Xian Chen, Xue‐Fei Cai, Hua Tang, Yuan Hu, Wen‐Lu Zhang, Xiang Liu, Quan‐Xin Long, Li Zhou, Na‐Na Tao, Hong‐Zhong Zhou, Qiu‐Xia Yang, Fang Ren, Lin He, Rui Gong, Ai‐Long Huang, Juan Chen – 6 April 2018 – Hepatitis B virus (HBV) infection remains a major health problem worldwide.

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