Neutrophils alleviate fibrosis in the CCl4‐induced mouse chronic liver injury model

Eiko Saijou, Yutaka Enomoto, Michitaka Matsuda, Cindy Yuet‐Yin Kok, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima – 12 April 2018 – Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte differentiation. Loss of Trib1 was previously shown to increase the neutrophil population in the spleen but lead to M2‐like macrophage reduction.

Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet‐induced insulin‐resistant mice

Feifei Zhang, Zhimin Hu, Gaopeng Li, Shaofeng Huo, Fengguang Ma, Aoyuan Cui, Yaqian Xue, Yamei Han, Qi Gong, Jing Gao, Hua Bian, Zhuoxian Meng, Haifu Wu, Gang Long, Yi Tan, Yan Zhang, Xu Lin, Xin Gao, Aimin Xu, Yu Li – 10 April 2018 – Insulin is critical for the regulation of de novo fatty acid synthesis, which converts glucose to lipid in the liver. However, how insulin signals are transduced into the cell and then regulate lipogenesis remains to be fully understood.

Influence of Progenitor‐Derived Regeneration Markers on Hepatitis C Virus–Related Cirrhosis Outcome (ANRS CO12 CirVir Cohort)

Dominique Wendum, Richard Layese, Nathalie Ganne‐Carrié, Valérie Bourcier, Fatiha Merabtene, Carole Cagnot, Emmanuel Sauce, Nathalie Barget, Pierre Bedossa, Benoit Terris, Janick Selves, Paulette Bioulac‐Sage, Nathalie Sturm, Christophe Sattonnet, Pierre Nahon, Françoise Roudot‐Thoraval, Marianne Ziol, for the ANRS CO12 CirVir Group – 10 April 2018 – Progenitor‐derived regeneration gives rise to the aberrant expression of biliary markers such as cytokeratin 7 (K7) and epithelial cell adhesion molecule (EpCAM) in hepatocytes.

Eversion Bile Duct Anastomosis: A Safe Alternative for Bile Duct Size Discrepancy in Deceased Donor Liver Transplantation

Pilar Leal‐Leyte, Greg J. McKenna, Richard M. Ruiz, Tiffany L. Anthony, Giovanna Saracino, Giuliano Testa, Goran B. Klintmalm, Peter T. W. Kim – 10 April 2018 – Bile duct size discrepancy in liver transplantation may increase the risk of biliary complications (BCs). The aim of this study was to evaluate the safety and outcomes of the eversion bile duct anastomosis technique in deceased donor liver transplantation (DDLT) with duct‐to‐duct anastomosis.

Living Donation Versus Donation After Circulatory Death Liver Transplantation for Low Model for End‐Stage Liver Disease Recipients

Catherine E. Kling, James D. Perkins, Jorge D. Reyes, Martin I. Montenovo – 10 April 2018 – In this era of organ scarcity, living donor liver transplantation (LDLT) is an alternative to using deceased donors, and in Western countries, it is more often used for recipients with low Model for End‐Stage Liver Disease (MELD) scores. We sought to compare the patient survival and graft survival between recipients of liver transplantation from living donors and donation after circulatory death (DCD) donors in patients with low MELD scores.

Hepatocytes and neutrophils cooperatively suppress bacterial infection by differentially regulating lipocalin‐2 and neutrophil extracellular traps

Hongjie Li, Dechun Feng, Yan Cai, Yudong Liu, Mingjiang Xu, Xiaogang Xiang, Zhou Zhou, Qiang Xia, Mariana J. Kaplan, Xiaoni Kong, Bin Gao – 10 April 2018 – Lipocalin‐2 (LCN2), also known as neutrophil gelatinase‐associated lipocalin (NGAL), a key antibacterial protein, is highly elevated in patients with end‐stage liver disease that is often associated with bacterial infection. LCN2 is expressed at high levels in both hepatocytes and neutrophils; however, how hepatocyte‐derived and neutrophil‐derived LCN2 cooperate to combat bacterial infection remains unclear.

12 Weeks of a Ribavirin‐Free Sofosbuvir and Nonstructural Protein 5AInhibitor Regimen Is Enough to Treat Recurrence of Hepatitis CAfter Liver Transplantation

Pauline Houssel‐Debry, Audrey Coilly, Claire Fougerou‐Leurent, Caroline Jezequel, Christophe Duvoux, Victor Ledinghen, Sylvie Radenne, Nassim Kamar, Vincent Leroy, Vincent Di Martino, Louis D'Alteroche, Valérie Canva, Filomena Conti, Jerome Dumortier, Hélène Montialoux, Pascal Lebray, Danielle Botta‐Fridlund, Albert Tran, Christophe Moreno, Christine Silvain, Camille Besch, Philippe Perre, Claire Francoz, Armando Abergel, François Habersetzer, Maryline Debette‐Gratien, Carole Cagnot, Alpha Diallo, Stéphane Chevaliez, Emilie Rossignol, Aurélie Veislinger, Jean‐Charles Duclos‐Vallee, Georges‐

Pediatric cirrhotic cardiomyopathy: Impact on liver transplant outcomes

Norman Junge, Claudia Junge, Julian Schröder, Eva‐Doreen Pfister, Christoph Leiskau, Dagmar Hohmann, Philipp Beerbaum, Ulrich Baumann – 10 April 2018 – In adults, cirrhotic cardiomyopathy (CCM) has a significant incidence and impact on liver transplantation. For pediatric liver transplantation (pLT), data on liver‐induced cardiac changes are scarce, and in particular, the comparison between cirrhotic and noncirrhotic liver disease has not been investigated.

Subscribe to