Jaswinder Singh Maras, Sukanta Das, Shvetank Sharma, Saggere M. Shasthry, Benoit Colsch, Christophe Junot, Richard Moreau, Shiv Kumar Sarin – 16 April 2018 – Severe alcoholic hepatitis (SAH) has a high mortality rate, and corticosteroid therapy is effective in 60% patients. This study aimed to investigate a baseline metabolic phenotype that could help stratify patients not likely to respond to steroid therapy and to have an unfavorable outcome.

Ângelo Zambam Mattos, Angelo Alves Mattos – 16 April 2018

Chenchen Wang, Ying Tong, Yankai Wen, Jie Cai, Han Guo, Lifeng Huang, Min Xu, Mingxuan Feng, Xiaosong Chen, Jianjun Zhang, Hailong Wu, Xiaoni Kong, Qiang Xia – 16 April 2018 – Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death worldwide. Increased lipogenesis has been reported to play a critical role in HCC progression. However, the underlying mechanism contributing to lipogenesis increase in HCC remains elusive. Here, we show that HCC‐associated protein TD26 (TD26) was highly expressed in HCC tumor tissues compared to matched normal tissues.

Theo Heller, Christopher Koh, Sonal Kumar – 14 April 2018

Nusrat Zaffar, Elisabeth Soete, Shital Gandhi, Parastoo Sayyar, Tim Van Mieghem, Rohan D'Souza – 14 April 2018 – Due to advances in obstetric and transplant medicine, women with a history of liver transplantation can have successful pregnancies. However, data on pregnancy outcomes is still limited, especially for women who have had a repeat liver transplant following graft rejection. This retrospective study compares pregnancy outcomes in women with single and repeat liver transplants managed at 2 tertiary hospitals in Toronto, Canada and Leuven, Belgium.

Eiko Saijou, Yutaka Enomoto, Michitaka Matsuda, Cindy Yuet‐Yin Kok, Shizuo Akira, Minoru Tanaka, Atsushi Miyajima – 12 April 2018 – Tribbles pseudokinase 1 (Trib1) is a negative regulator of CCAAT/enhancer binding protein α (C/EBPα) and is known to induce granulopoiesis while suppressing monocyte differentiation. Loss of Trib1 was previously shown to increase the neutrophil population in the spleen but lead to M2‐like macrophage reduction.

Jian‐Hong Fang, Zi‐Jun Zhang, Li‐Ru Shang, Yu‐Wei Luo, Yi‐Fang Lin, Yunfei Yuan, Shi‐Mei Zhuang – 10 April 2018 – Increased vascular permeability facilitates metastasis. Emerging evidence indicates that secreted microRNAs (miRNAs) may mediate the crosstalk between cancer and stromal cells. To date, whether and how secreted miRNAs affect vascular permeability remains unclear. Based on deep sequencing and quantitative PCR, we found that higher level of serum miR‐103 was associated with higher metastasis potential of hepatocellular carcinoma (HCC).

Norman Junge, Claudia Junge, Julian Schröder, Eva‐Doreen Pfister, Christoph Leiskau, Dagmar Hohmann, Philipp Beerbaum, Ulrich Baumann – 10 April 2018 – In adults, cirrhotic cardiomyopathy (CCM) has a significant incidence and impact on liver transplantation. For pediatric liver transplantation (pLT), data on liver‐induced cardiac changes are scarce, and in particular, the comparison between cirrhotic and noncirrhotic liver disease has not been investigated.

Pauline Houssel‐Debry, Audrey Coilly, Claire Fougerou‐Leurent, Caroline Jezequel, Christophe Duvoux, Victor Ledinghen, Sylvie Radenne, Nassim Kamar, Vincent Leroy, Vincent Di Martino, Louis D'Alteroche, Valérie Canva, Filomena Conti, Jerome Dumortier, Hélène Montialoux, Pascal Lebray, Danielle Botta‐Fridlund, Albert Tran, Christophe Moreno, Christine Silvain, Camille Besch, Philippe Perre, Claire Francoz, Armando Abergel, François Habersetzer, Maryline Debette‐Gratien, Carole Cagnot, Alpha Diallo, Stéphane Chevaliez, Emilie Rossignol, Aurélie Veislinger, Jean‐Charles Duclos‐Vallee, Georges‐

Hongjie Li, Dechun Feng, Yan Cai, Yudong Liu, Mingjiang Xu, Xiaogang Xiang, Zhou Zhou, Qiang Xia, Mariana J. Kaplan, Xiaoni Kong, Bin Gao – 10 April 2018 – Lipocalin‐2 (LCN2), also known as neutrophil gelatinase‐associated lipocalin (NGAL), a key antibacterial protein, is highly elevated in patients with end‐stage liver disease that is often associated with bacterial infection. LCN2 is expressed at high levels in both hepatocytes and neutrophils; however, how hepatocyte‐derived and neutrophil‐derived LCN2 cooperate to combat bacterial infection remains unclear.