Management of Coagulation and Anticoagulation in Liver Transplantation Candidates

Patrick Northup, Bethany Reutemann – 24 August 2018 – Hemostasis is a complex balance of clot formation and dissolution that is largely modulated by protein synthesis and degradation in the liver. In the state of end‐stage liver disease, there is a disruption of the hemostatic system due to hepatic protein synthetic dysfunction. Because historical clinical laboratory testing often only analyzes a portion of the hemostasis system, the clinician may be misled into believing that cirrhosis patients are imbalanced with a tendency toward bleeding.

Onset of Donor Warm Ischemia Time in Donation After Circulatory Death Liver Transplantation: Hypotension or Hypoxia?

Marit Kalisvaart, Jubi E. Haan, Wojciech G. Polak, Jan N. M. IJzermans, Diederik Gommers, Herold J. Metselaar, Jeroen Jonge – 24 August 2018 – The aim of this study was to investigate the impact of hypoxia and hypotension during the agonal phase of donor warm ischemia time (DWIT) on hepatic ischemia/reperfusion injury (IRI) and complications in donation after circulatory death (DCD) liver transplantation. A retrospective single‐center study of 93 DCD liver transplants (Maastricht type III) was performed.

mTOR Signaling in X/A‐Like Cells Contributes to Lipid Homeostasis in Mice

Ziru Li, Ruili Yu, Wenzhen Yin, Yan Qin, Liangxiao Ma, Michael Mulholland, Weizhen Zhang – 23 August 2018 – Gastric mechanistic target of rapamycin (mTOR) signaling is inversely associated with the expression and secretion of ghrelin, a 28‐aa peptide hormone produced by gastric X/A‐like cells. Ghrelin contributes to obesity and hepatic steatosis. We sought to control global lipid metabolism via the manipulation of gastric mTOR signaling in X/A‐like cells. We established a ghrl‐cre transgene in which the Cre enzyme is expressed in X/A‐like cells under the control of the ghrelin‐promoter.

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