Follicular T Helper Cell Signatures in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Leonie Adam, Katharina Zoldan, Maike Hofmann, Michael Schultheiss, Dominik Bettinger, Christoph Neumann‐Haefelin, Robert Thimme, Tobias Boettler – 7 September 2018 – Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are the most common cholestatic liver diseases. While PBC is generally accepted to be an autoimmune disorder characterized by pathognomonic autoantibodies against mitochondrial antigens, the pathogenesis of PSC is less precisely defined; however, some degree of altered immunity toward autoantigens has been suggested.

Aortic Versus Dual Perfusion for Retrieval of the Liver After Brain Death: A National Registry Analysis

Ahmer M. Hameed, Tony Pang, Peter Yoon, Glenda Balderson, Ronald De Roo, Lawrence Yuen, Vincent Lam, Jerome Laurence, Michael Crawford, Richard D. M. Allen, Wayne J. Hawthorne, Henry C. Pleass – 7 September 2018 – There is lack of consensus in the literature regarding the comparative efficacy of in situ aortic‐only compared with dual (aortic and portal venous) perfusion for retrieval and transplantation of the liver.

Great Expectations: Principal Investigator and Trainee Perspectives on Hiring, Supervision, and Mentoring

Leonard Kaps, Jonathan G. Stine, Jessica Mellinger, Silvia Vilarinho – 7 September 2018 – A functioning mentor–trainee relationship is of high importance in academia. Discrepancies in expectations between principal investigators (PIs) and trainees are a source of misunderstandings and conflicts, endangering scientific progress and career advancement.

Dipeptidyl Peptidase‐4 Is a Pro‐Recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells

Nádia Duarte, Inês Coelho, Denys Holovanchuk, Joana Inês Almeida, Carlos Penha‐Gonçalves, Maria Paula Macedo – 7 September 2018 – Dipeptidyl peptidase‐4 (DPP‐4 or clusters of differentiation [CD]26) is a multifunctional molecule with established roles in metabolism. Pharmacologic inhibition of DPP‐4 is widely used to improve glycemic control through regulation of the incretin effect. Colaterally, CD26/DPP‐4 inhibition appears to be beneficial in many inflammatory conditions, namely in delaying progression of liver pathology.

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