The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice: A Public Health Perspective
Saumya Pandey – 4 August 2018
Terlipressin Is Superior to Noradrenaline in the Management of Acute Kidney Injury in Acute on Chronic Liver Failure
Vinod Arora, Rakhi Maiwall, Vijayaraghavan Rajan, Ankur Jindal, Saggere Muralikrishna Shasthry, Guresh Kumar, Priyanka Jain, Shiv Kumar Sarin – 3 August 2018 – Hepatorenal syndrome (HRS) carries a high short‐term mortality in patients with cirrhosis and acute on chronic liver failure (ACLF). Terlipressin and noradrenaline are routinely used in cirrhosis with HRS and have been found to be equally effective. There are no data comparing the efficacy of terlipressin with noradrenaline in ACLF patients with HRS.
Trimming the Fat: Acetyl‐CoA Carboxylase Inhibition for the Management of NAFLD
Norihiro Imai, David E. Cohen – 3 August 2018
Clinical Consequences of Cardiomyopathy in Children With Biliary Atresia Requiring Liver Transplantation
Noelle M. Gorgis, Curtis Kennedy, Fong Lam, Kathleen Thompson, Jorge Coss‐Bu, Ayse Akcan Arikan, Trung Nguyen, Kathleen Hosek, Tamir Miloh, Saul J. Karpen, Daniel J. Penny, John Goss, Moreshwar S. Desai – 3 August 2018 – Cirrhotic cardiomyopathy (CCM), a comorbidity of end‐stage cirrhotic liver disease, remains uncharacterized in children, largely because of a lack of an established pediatric definition.
Clinical Consequences of Cardiomyopathy in Children With Biliary Atresia Requiring Liver Transplantation
Noelle M. Gorgis, Curtis Kennedy, Fong Lam, Kathleen Thompson, Jorge Coss‐Bu, Ayse Akcan Arikan, Trung Nguyen, Kathleen Hosek, Tamir Miloh, Saul J. Karpen, Daniel J. Penny, John Goss, Moreshwar S. Desai – 3 August 2018 – Cirrhotic cardiomyopathy (CCM), a comorbidity of end‐stage cirrhotic liver disease, remains uncharacterized in children, largely because of a lack of an established pediatric definition.
Patient‐Reported Outcomes and the Economic Effects of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis: The Value Proposition
Zobair M. Younossi – 2 August 2018 – Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) can progress to cirrhosis, hepatocellular carcinoma (HCC), death, or liver transplantation. NASH has also been associated with impaired health‐related quality of life and poses a significant economic burden.
Too Stiff, Too Late . . . Timing Is Everything in Antiangiogenic Treatment of Liver Fibrosis
Thomas Greuter, Vijay H. Shah – 2 August 2018
A Case of Immune‐Mediated Liver Injury Induced by Olaparib
Manuel Tufoni, Carmen Serena Ricci, Giacomo Zaccherini – 2 August 2018
Negative Regulation of Mitochondrial Antiviral Signaling Protein–Mediated Antiviral Signaling by the Mitochondrial Protein LRPPRC During Hepatitis C Virus Infection
Giulia Refolo, Fabiola Ciccosanti, Martina Di Rienzo, Ariel Basulto Perdomo, Marta Romani, Tonino Alonzi, Marco Tripodi, Giuseppe Ippolito, Mauro Piacentini, Gian Maria Fimia – 2 August 2018 – Hepatitis C virus (HCV) is highly efficient in establishing a chronic infection, having evolved multiple strategies to suppress the host antiviral responses. The HCV nonstructural 5A (NS5A) protein, in addition to its role in viral replication and assembly, has long been known to hamper the interferon (IFN) response.
Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis
José Alcaraz‐Quiles, Mireia Casulleras, Karl Oettl, Esther Titos, Roger Flores‐Costa, Marta Duran‐Güell, Cristina López‐Vicario, Marco Pavesi, Rudolf E. Stauber, Vicente Arroyo, Joan Clària – 2 August 2018 – Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating forms of oxidized albumin, namely human nonmercaptalbumin 1 (HNA1) and HNA2, is a common finding in cirrhosis.