Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ratna B. Ray, Ranjit Ray – 13 August 2018 – Chronic hepatitis C virus (HCV) infection‐associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end‐stage liver disease. HCV infects hepatocytes; however, initial manifestation of liver disease is mostly displayed in hepatic stellate cells (HSCs), causing fibrosis/cirrhosis, and is believed to occur from inflammation in the liver.

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ratna B. Ray, Ranjit Ray – 13 August 2018 – Chronic hepatitis C virus (HCV) infection‐associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end‐stage liver disease. HCV infects hepatocytes; however, initial manifestation of liver disease is mostly displayed in hepatic stellate cells (HSCs), causing fibrosis/cirrhosis, and is believed to occur from inflammation in the liver.

Genetics Meets Therapy? Exome‐wide Association Study Reveals a Loss‐of‐Function Variant in 17‐Beta‐Hydroxysteroid Dehydrogenase 13 That Protects Patients From Liver Damage and Nonalcoholic Fatty Liver Disease Progression

Macrophage‐Specific Hypoxia‐Inducible Factor‐1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Xiaojing Wang, Marcelle de Carvalho Ribeiro, Arvin Iracheta‐Vellve, Patrick Lowe, Aditya Ambade, Abhishek Satishchandran, Terence Bukong, Donna Catalano, Karen Kodys, Gyongyi Szabo – 13 August 2018 – Inflammatory cell activation drives diverse cellular programming during hepatic diseases. Hypoxia‐inducible factors (HIFs) have recently been identified as important regulators of immunity and inflammation.

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