Predicting Postoperative Liver Dysfunction Based on Blood‐Derived MicroRNA Signatures

Patrick Starlinger, Hubert Hackl, David Pereyra, Susanna Skalicky, Elisabeth Geiger, Michaela Finsterbusch, Dietmar Tamandl, Christine Brostjan, Thomas Grünberger, Matthias Hackl, Alice Assinger – 19 February 2019 – There is an urgent need for an easily assessable preoperative test to predict postoperative liver function recovery and thereby determine the optimal time point of liver resection, specifically as current markers are often expensive, time consuming, and invasive.

Ex Vivo Hepatocyte Reprograming Promotes Homology‐Directed DNA Repair to Correct Metabolic Disease in Mice After Transplantation

Caitlin J. VanLith, Rebekah M. Guthman, Clara T. Nicolas, Kari L. Allen, Yuanhang Liu, Jennifer A. Chilton, Zachariah P. Tritz, Scott L. Nyberg, Robert A. Kaiser, Joseph B. Lillegard, Raymond D. Hickey – 15 February 2019 – Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease.

Application of 3‐Dimensional Printing in Pediatric Living Donor Liver Transplantation: A Single‐Center Experience

Pusen Wang, Weitao Que, Mingman Zhang, Xiaoke Dai, Kanru Yu, Chunguang Wang, Zhihai Peng, Lin Zhong – 15 February 2019 – Three‐dimensional (3D) printing has been used to support organ transplantations. However, whether it helps remains unclear. This study aimed to present and assess the application of 3D‐printed liver models in pediatric living donor liver transplantation (LDLT). The 3D images were printed to touchable liver models with transparent liver parenchyma, specifically colored hepatic vessels, and biliary structures.

The Yield and Safety of Screening Colonoscopy in Patients Evaluated for Liver Transplantation

Rosalie C. Oey, Laurelle van Tilburg, Nicole S. Erler, Herold J. Metselaar, Manon C.W. Spaander, Henk R. van Buuren, Robert A. de Man – 14 February 2019 – Colorectal cancer (CRC) screening with colonoscopy is commonly used in patients who are candidates for liver transplantation. We initiated this study to define the risk‐benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre–liver transplantation screening between 2004 and 2017 was conducted.

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