Effects of Endotoxin on Type 3 Inositol 1,4,5‐Trisphosphate Receptor in Human Cholangiocytes

Andressa Franca, Antonio Carlos Melo Lima Filho, Mateus T. Guerra, Jittima Weerachayaphorn, Marcone Loiola dos Santos, Basile Njei, Marie Robert, Cristiano Xavier Lima, Paula Vieira Teixeira Vidigal, Jesus M. Banales, Meenakshisundaram Ananthanarayanan, M. Fatima Leite, Michael H. Nathanson – 23 August 2018 – Clinical conditions that result in endotoxemia, such as sepsis and alcoholic hepatitis (AH), often are accompanied by cholestasis.

Serum Angiopoietin‐2 Predicts Mortality and Kidney Outcomes in Decompensated Cirrhosis

Andrew S. Allegretti, Xavier Vela Parada, Guillermo A. Ortiz, Joshua Long, Scott Krinsky, Sophia Zhao, Bryan C. Fuchs, Mozhdeh Sojoodi, Dongsheng Zhang, S. Ananth Karumanchi, Sahir Kalim, Sagar U. Nigwekar, Ravi I. Thadhani, Samir M. Parikh, Raymond T. Chung – 23 August 2018 – Acute kidney injury in decompensated cirrhosis has limited therapeutic options, and novel mechanistic targets are urgently needed. Angiopoietin‐2 is a context‐specific antagonist of Tie2, a receptor that signals vascular quiescence.

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