Genetics Meets Therapy? Exome‐wide Association Study Reveals a Loss‐of‐Function Variant in 17‐Beta‐Hydroxysteroid Dehydrogenase 13 That Protects Patients From Liver Damage and Nonalcoholic Fatty Liver Disease Progression

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F. Hofmann, Peter L.M. Jansen, Jan G. Hengstler, Raymond Reif – 13 August 2018 – Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease.

Characteristics of Immune Response to Tumor‐Associated Antigens and Immune Cell Profile in Patients With Hepatocellular Carcinoma

Yuki Inada, Eishiro Mizukoshi, Takuya Seike, Toshikatsu Tamai, Noriho Iida, Masaaki Kitahara, Tatsuya Yamashita, Kuniaki Arai, Takeshi Terashima, Kazumi Fushimi, Taro Yamashita, Masao Honda, Shuichi Kaneko – 13 August 2018 – Host antitumor immune responses may be different between hepatocellular carcinoma (HCC) caused by metabolic disorders and HCC associated with hepatitis virus infection. In this study, we examined the immune response of tumor‐associated antigen (TAA)–specific T cells and immune cell profile in patients with HCC separated by cause.

Donor Dopamine Does Not Affect Liver Graft Survival: Evidence of Safety From a Randomized Controlled Trial

Urs Benck, Matthias Jung, Bernd Krüger, Anja Grimm, Christel Weiss, Benito A. Yard, Frank Lehner, Anja Kiessling, Lutz Fischer, Anja Gallinat, Axel Kleespies, Thomas Lorf, Robert Sucher, Christian Mönch, Marcus N. Scherer, Axel Rahmel, Peter Schemmer, Bernhard K. Krämer, Peter Schnuelle – 13 August 2018 – Treatment of donation after brain death (DBD) donors with low‐dose dopamine improves the outcomes after kidney and heart transplantation.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F. Hofmann, Peter L.M. Jansen, Jan G. Hengstler, Raymond Reif – 13 August 2018 – Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease.

Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis

Guido Carpino, Vincenzo Cardinale, Trine Folseraas, Diletta Overi, Krzysztof Grzyb, Daniele Costantini, Pasquale Bartolomeo Berloco, Sabina Di Matteo, Tom Hemming Karlsen, Domenico Alvaro, Eugenio Gaudio – 13 August 2018 – Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC.

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ratna B. Ray, Ranjit Ray – 13 August 2018 – Chronic hepatitis C virus (HCV) infection‐associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end‐stage liver disease. HCV infects hepatocytes; however, initial manifestation of liver disease is mostly displayed in hepatic stellate cells (HSCs), causing fibrosis/cirrhosis, and is believed to occur from inflammation in the liver.

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ratna B. Ray, Ranjit Ray – 13 August 2018 – Chronic hepatitis C virus (HCV) infection‐associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end‐stage liver disease. HCV infects hepatocytes; however, initial manifestation of liver disease is mostly displayed in hepatic stellate cells (HSCs), causing fibrosis/cirrhosis, and is believed to occur from inflammation in the liver.

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