Donor‐Specific Antibodies in Pediatric Intestinal and Multivisceral Transplantation: The Role of Liver and Human Leukocyte Antigen Mismatching

Paloma Talayero, Esther Ramos Boluda, Elena Gómez Massa, María José Castro Panete, Gerardo Prieto Bozano, Francisco Hernández Oliveros, Manuel López Santamaría, Jorge Calvo Pulido, Estela Paz‐Artal, Esther Mancebo – 16 August 2018 – Rejection is one of the most important drawbacks for graft and patient survival in intestinal and multivisceral transplantation.

Flare of Autoimmune Hepatitis Causing Acute on Chronic Liver Failure: Diagnosis and Response to Corticosteroid Therapy

Lovkesh Anand, Ashok Choudhury, Chhagan Bihari, Barjesh C. Sharma, Manoj Kumar, Rakhi Maiwall, Soek Siam Tan, Samir R. Shah, Saeed Hamid, Amna S. Butt, Wasim Jafri, Yogesh K. Chawla, Sunil Taneja, Ajay Duseja, Radha K. Dhiman, Mamun Al Mahtab, Hasmik Ghazinyan, Zhongping Duan, Yu Chen, Akash Shukla, Jinhua Hu, Zaigham Abbas, Sombat Treeprasertsuk, Laurentius A. Lesmana, Cosmas R Lesmana, Jose D. Sollano, Gian Carpio, Manoj K. Sahu, Guresh Kumar, Shiv K.

Donor Dopamine Does Not Affect Liver Graft Survival: Evidence of Safety From a Randomized Controlled Trial

Urs Benck, Matthias Jung, Bernd Krüger, Anja Grimm, Christel Weiss, Benito A. Yard, Frank Lehner, Anja Kiessling, Lutz Fischer, Anja Gallinat, Axel Kleespies, Thomas Lorf, Robert Sucher, Christian Mönch, Marcus N. Scherer, Axel Rahmel, Peter Schemmer, Bernhard K. Krämer, Peter Schnuelle – 13 August 2018 – Treatment of donation after brain death (DBD) donors with low‐dose dopamine improves the outcomes after kidney and heart transplantation.

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood

Ahmed Ghallab, Ute Hofmann, Selahaddin Sezgin, Nachiket Vartak, Reham Hassan, Ayham Zaza, Patricio Godoy, Kai Markus Schneider, Georgia Guenther, Yasser A. Ahmed, Aya A. Abbas, Verena Keitel, Lars Kuepfer, Steven Dooley, Frank Lammert, Christian Trautwein, Michael Spiteller, Dirk Drasdo, Alan F. Hofmann, Peter L.M. Jansen, Jan G. Hengstler, Raymond Reif – 13 August 2018 – Bile duct ligation (BDL) is an experimental procedure that mimics obstructive cholestatic disease.

Neoplastic Transformation of the Peribiliary Stem Cell Niche in Cholangiocarcinoma Arisen in Primary Sclerosing Cholangitis

Guido Carpino, Vincenzo Cardinale, Trine Folseraas, Diletta Overi, Krzysztof Grzyb, Daniele Costantini, Pasquale Bartolomeo Berloco, Sabina Di Matteo, Tom Hemming Karlsen, Domenico Alvaro, Eugenio Gaudio – 13 August 2018 – Primary sclerosing cholangitis (PSC) is a chronic inflammatory cholangiopathy frequently complicated by cholangiocarcinoma (CCA). Massive proliferation of biliary tree stem/progenitor cells (BTSCs), expansion of peribiliary glands (PBGs), and dysplasia were observed in PSC.

Hepatitis C Virus Manipulates Humans as its Favorite Host for a Long‐Term Relationship

Ratna B. Ray, Ranjit Ray – 13 August 2018 – Chronic hepatitis C virus (HCV) infection‐associated liver disease is a global health problem. HCV often causes silent disease, and eventually progresses to end‐stage liver disease. HCV infects hepatocytes; however, initial manifestation of liver disease is mostly displayed in hepatic stellate cells (HSCs), causing fibrosis/cirrhosis, and is believed to occur from inflammation in the liver.

Macrophage‐Specific Hypoxia‐Inducible Factor‐1α Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis

Xiaojing Wang, Marcelle de Carvalho Ribeiro, Arvin Iracheta‐Vellve, Patrick Lowe, Aditya Ambade, Abhishek Satishchandran, Terence Bukong, Donna Catalano, Karen Kodys, Gyongyi Szabo – 13 August 2018 – Inflammatory cell activation drives diverse cellular programming during hepatic diseases. Hypoxia‐inducible factors (HIFs) have recently been identified as important regulators of immunity and inflammation.

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