Bis‐choline Tetrathiomolybdate as Old Drug in a New Design for Wilson’s Disease: Good for Brain and Liver?
Wolfgang Stremmel – 2 August 2018
Pulse Oximetry Is Insensitive for Detection of Hepatopulmonary Syndrome in Patients Evaluated for Liver Transplantation
Kimberly A. Forde, Michael B. Fallon, Michael J. Krowka, Michael Sprys, David S. Goldberg, Karen L. Krok, Mamta Patel, Grace Lin, Jae K. Oh, Carl D. Mottram, Paul D. Scanlon, Steven M. Kawut, for the Pulmonary Vascular Complications of Liver Disease 2 Study Group – 2 August 2018 – Screening for hepatopulmonary syndrome (HPS) using pulse oximetry is recommended in liver transplant (LT) candidates because mortality is increased, independently of the severity of the oxygenation defect. LT exception points may be afforded to those with HPS and severe hypoxemia.
Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis
José Alcaraz‐Quiles, Mireia Casulleras, Karl Oettl, Esther Titos, Roger Flores‐Costa, Marta Duran‐Güell, Cristina López‐Vicario, Marco Pavesi, Rudolf E. Stauber, Vicente Arroyo, Joan Clària – 2 August 2018 – Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating forms of oxidized albumin, namely human nonmercaptalbumin 1 (HNA1) and HNA2, is a common finding in cirrhosis.
A Three‐Pronged Epigenetic Approach to the Treatment of Hepatocellular Carcinoma
Ryan A. Hlady, Keith D. Robertson – 2 August 2018
Transplanting Hepatitis C–Seropositive, Nucleic Acid Test–Negative Donor Organs Into Hepatitis C–Negative Recipients
Trana Hussaini, Mel Krajden, Robert A. Mitchell, Eric M. Yoshida – 2 August 2018
Negative Regulation of Mitochondrial Antiviral Signaling Protein–Mediated Antiviral Signaling by the Mitochondrial Protein LRPPRC During Hepatitis C Virus Infection
Giulia Refolo, Fabiola Ciccosanti, Martina Di Rienzo, Ariel Basulto Perdomo, Marta Romani, Tonino Alonzi, Marco Tripodi, Giuseppe Ippolito, Mauro Piacentini, Gian Maria Fimia – 2 August 2018 – Hepatitis C virus (HCV) is highly efficient in establishing a chronic infection, having evolved multiple strategies to suppress the host antiviral responses. The HCV nonstructural 5A (NS5A) protein, in addition to its role in viral replication and assembly, has long been known to hamper the interferon (IFN) response.
Oxidized Albumin Triggers a Cytokine Storm in Leukocytes Through P38 Mitogen‐Activated Protein Kinase: Role in Systemic Inflammation in Decompensated Cirrhosis
José Alcaraz‐Quiles, Mireia Casulleras, Karl Oettl, Esther Titos, Roger Flores‐Costa, Marta Duran‐Güell, Cristina López‐Vicario, Marco Pavesi, Rudolf E. Stauber, Vicente Arroyo, Joan Clària – 2 August 2018 – Decompensated cirrhosis is characterized by exuberant systemic inflammation. Although the inducers of this feature remain unknown, the presence of circulating forms of oxidized albumin, namely human nonmercaptalbumin 1 (HNA1) and HNA2, is a common finding in cirrhosis.
Prospective Intraindividual Comparison of Magnetic Resonance Imaging With Gadoxetic Acid and Extracellular Contrast for Diagnosis of Hepatocellular Carcinomas Using the Liver Imaging Reporting and Data System
Ji Hye Min, Jong Man Kim, Young Kon Kim, Tae Wook Kang, Soon Jin Lee, Gyu Seong Choi, Seo‐Youn Choi, Soohyun Ahn – 2 August 2018 – We intraindividually compared the efficacy of magnetic resonance imaging (MRI) with extracellular contrast agents (ECA‐MRI) and MRI with hepatobiliary agents (HBA‐MRI) for the diagnosis of hepatocellular carcinoma (HCC) using the Liver Imaging Reporting and Data System (LI‐RADS).
Ductular Reaction in Liver Diseases: Pathological Mechanisms and Translational Significances
Keisaku Sato, Marco Marzioni, Fanyin Meng, Heather Francis, Shannon Glaser, Gianfranco Alpini – 2 August 2018 – Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly observed in biliary disorders. It can also be identified in various liver disorders including nonalcoholic fatty liver disease. DR is associated with liver fibrosis and damage, and the extent of DR parallels to patient mortality.
CCL15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma
Long‐Zi Liu, Zhao Zhang, Bo‐Hao Zheng, Yang Shi, Men Duan, Li‐Jie Ma, Zhi‐Chao Wang, Liang‐Qing Dong, Ping‐Ping Dong, Jie‐Yi Shi, Shu Zhang, Zhen‐Bin Ding, Ai‐Wu Ke, Ya Cao, Xiao‐Ming Zhang, Ruibin Xi, Jian Zhou, Jia Fan, Xiao‐Ying Wang, Qiang Gao – 2 August 2018 – Chemokines play a key role in orchestrating the recruitment and positioning of myeloid cells within the tumor microenvironment. However, the tropism regulation and functions of these cells in hepatocellular carcinoma (HCC) are not completely understood.