Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

Luis Calzadilla‐Bertot, Gary P. Jeffrey, Bryon Jacques, Geoffrey McCaughan, Michael Crawford, Peter Angus, Robert Jones, Edward Gane, Stephen Munn, Graeme Macdonald, Jonathan Fawcett, Alan Wigg, John Chen, Michael Fink, Leon A. Adams – 4 January 2019 – The worldwide increase in obesity and diabetes has led to predictions that nonalcoholic steatohepatitis (NASH) will become the leading indication for orthotopic liver transplantation (OLT). Data supporting this prediction from outside the United States are limited.

Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High‐Fat Diet

Sereana Wan, Folkert Kuipers, Rick Havinga, Hiromi Ando, Dennis E. Vance, René L. Jacobs, Jelske N. Veen – 2 January 2019 – Phosphatidylethanolamine N‐methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt–/– mice fed a high‐fat diet (HFD) develop steatohepatitis. Interestingly, portions of the ER located close to the canaliculus are enriched in PEMT.

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