Sereana Wan, Folkert Kuipers, Rick Havinga, Hiromi Ando, Dennis E. Vance, René L. Jacobs, Jelske N. Veen – 2 January 2019 – Phosphatidylethanolamine N‐methyltransferase (PEMT) is a hepatic integral membrane protein localized to the endoplasmic reticulum (ER). PEMT catalyzes approximately 30% of hepatic phosphatidylcholine (PC) biosynthesis. Pemt–/– mice fed a high‐fat diet (HFD) develop steatohepatitis. Interestingly, portions of the ER located close to the canaliculus are enriched in PEMT.

Nayantara Orekondy, Sheila Eswaran – 2 January 2019

Jerome C. Edelson, Don C. Rockey – 2 January 2019

Jesus M. Banales, Ariel E. Feldstein, Hanna Sänger, Veronika Lukacs‐Kornek, Gyongyi Szabo, Miroslaw Kornek – 2 January 2019 – Extracellular vesicles (EVs) are small and heterogeneous membrane‐bound structures released by cells and found in all biological fluids. They are effective intercellular communicators, acting on a number of close and/or distant target cells. EV cargo may reflect the cell of origin as well as the specific stress that induces their formation and release.

1 January 2019

Catherine T. Frenette – 1 January 2019

Umberto Cillo, Laura Saracino, Alessandro Vitale, Alessandra Bertacco, Mauro Salizzoni, Francesco Lupo, Michele Colledan, Vittorio Corno, Giorgio Rossi, Paolo Reggiani, Umberto Baccarani, Vittorio Bresàdola, Luciano De Carlis, Iacopo Mangoni, Raphael Ramirez Morales, Salvatore Agnes, Erida Nure – 28 December 2018 – Early everolimus (EVR) introduction and tacrolimus (TAC) minimization after liver transplantation may represent a novel immunosuppressant approach. This phase 2, multicenter, randomized, open‐label trial evaluated the safety and efficacy of early EVR initiation.

Gil Ben‐Yakov, Hawwa Alao, John P. Haydek, Nancy Fryzek, Min Ho Cho, Mehdi Hemmati, Vikram Samala, Margaret Shovlin, Kieron Dunleavy, Wyndham Wilson, Elizabeth C. Jones, Yaron Rotman – 28 December 2018 – Nonalcoholic fatty liver disease is the most common liver disorder in the developed world. Although typically reflecting caloric overload, it can also be secondary to drug toxicity. We aimed to describe the incidence and risk factors for de novo steatosis during chemotherapy for non‐Hodgkin lymphoma (NHL).

Julie Di Martino, Patrice Mascalchi, Philippe Legros, Sabrina Lacomme, Etienne Gontier, Paulette Bioulac‐Sage, Charles Balabaud, Violaine Moreau, Frédéric Saltel – 28 December 2018 – Liver sinusoidal endothelial cells (LSECs) possess fenestrae, which are key for the exchange between blood and hepatocytes. Alterations in their number or diameter have important implications for hepatic function in liver diseases. They are lost early in the development of hepatic fibrosis through a process called capillarization.

Barbara Ulmasov, Hidenao Noritake, Peter Carmichael, Kiyoko Oshima, David W. Griggs, Brent A. Neuschwander‐Tetri – 27 December 2018 – The presence and stage of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH) is strongly associated with mortality. Thus, both preventing and reversing fibrosis are critically important approaches to prevent death or the need for liver transplantation from NASH.