Jingjing Tong, Cui‐Juan Han, Jia‐Zhen Zhang, Wen‐Zhi He, Guo‐Jun Zhao, Xu Cheng, Lei Zhang, Ke‐Qiong Deng, Ye Liu, Hui‐Fen Fan, Song Tian, Jingjing Cai, Zan Huang, Zhi‐Gang She, Peng Zhang, Hongliang Li – 12 February 2019 – Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field.

Patrick J. McKiernan, Armando Ganoza, James E. Squires, Robert H. Squires, Jerry Vockley, George Mazariegos, Kyle Soltys, Qing Sun, Rakesh Sindhi – 12 February 2019 – Indications for liver transplantation (LT) in metabolic disease are evolving. We reviewed the US experience with primary LT for metabolic disease in the Scientific Registry for Transplant Recipients (October 1987 to June 2017) to determine the following: temporal changes in indications, longterm outcomes, and factors predicting survival.

Mattias Mandorfer, Manfred Hecking – 11 February 2019

Nima Memaran, Bianca Borchert‐Mörlins, Bernhard M. W. Schmidt, Rizky I. Sugianto, Hannes Wilke, Ricarda Blöte, Ulrich Baumann, Elena Bauer, Anika von Wick, Norman Junge, Christoph Leiskau, Eva D. Pfister, Daniela Thurn‐Valsassina, Nicolas Richter, Imeke Goldschmidt, Anette Melk – 11 February 2019 – Cardiovascular (CV) events account for 8%‐13% of deaths after liver transplantation (LT) in adulthood. Although CV risk factors (RFs) are present, little is known about the prevalence of subclinical CV target organ damage (TOD) in children after LT.

Martijn C.G.J. Brouwers, Nynke Simons, Coen D.A. Stehouwer, Ger H. Koek, Nicolaas C. Schaper, Aaron Isaacs – 11 February 2019 – Coronary artery disease (CAD) is the principal cause of death in patients with nonalcoholic fatty liver disease (NAFLD). The aim of the present study was to investigate whether NAFLD is causally involved in the pathogenesis of CAD.

Paula C. Zimbrean, Geliang Gan, Yanhong Deng, Sukru Emre – 11 February 2019 – Body image (BI) concerns have been reported to play a significant role in the psychological adaptation after organ transplantation. There is a paucity of data about BI beliefs in liver transplant recipients. We report the results of a cross‐sectional study of 177 liver transplant recipients for whom we assessed BI, anxiety, depression, and quality of life (QOL) using validated instruments. Our results indicate that higher BI concerns correlated with higher levels of anxiety and depression.

Ana I. Álvarez‐Mercado, José Gulfo, Manuel Romero Gómez, Mónica B. Jiménez‐Castro, Jordi Gracia‐Sancho, Carmen Peralta – 10 February 2019 – In the field of liver transplantation, the demand for adequate allografts greatly exceeds the supply. Therefore, expanding the donor pool to match the growing demand is mandatory. The present review summarizes current knowledge of the pathophysiology of ischemia/reperfusion injury in steatotic grafts, together with recent pharmacological approaches aimed at maximizing the utilization of these livers for transplantation.

Mary Drinane – 8 February 2019

Tomi Jun, Yao‐Chun Hsu, Shintaro Ogawa, Yen‐Tsung Huang, Ming‐Lun Yeh, Cheng‐Hao Tseng, Chung‐Feng Huang, Chi‐Ming Tai, Chia‐Yen Dai, Jee‐Fu Huang, Wan‐Long Chuang, Ming‐Lung Yu, Yasuhito Tanaka, Mindie H. Nguyen – 8 February 2019 – Mac‐2 binding protein glycosylation isomer (M2BPGi) is a novel glycoprotein biomarker that correlates with liver fibrosis. It has been investigated in East Asian populations as a hepatocellular carcinoma (HCC) biomarker.

Yu Qiao, Jingxiao Wang, Eylul Karagoz, Binyong Liang, Xinhua Song, Runze Shang, Katja Evert, Meng Xu, Li Che, Matthias Evert, Diego F. Calvisi, Junyan Tao, Bruce Wang, Satdarshan P. Monga, Xin Chen – 8 February 2019 – Inactivating mutations of axis inhibition protein 1 (AXIN1), a negative regulator of the Wnt/β‐Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting approximately 10% of cases.