Pregnane X Receptor Regulates Liver Size and Liver Cell Fate by Yes‐Associated Protein Activation in Mice

Yiming Jiang, Dechun Feng, Xiaochao Ma, Shicheng Fan, Yue Gao, Kaili Fu, Ying Wang, Jiahong Sun, Xinpeng Yao, Conghui Liu, Huizhen Zhang, Leqian Xu, Aiming Liu, Frank J. Gonzalez, Yingzi Yang, Bin Gao, Min Huang, Huichang Bi – 26 July 2018 – Activation of pregnane X receptor (PXR), a nuclear receptor that controls xenobiotic and endobiotic metabolism, is known to induce liver enlargement, but the molecular signals and cell types responding to PXR‐induced hepatomegaly remain unknown.

Relationship Between Total Body Protein and Cross‐Sectional Skeletal Muscle Area in Liver Cirrhosis Is Influenced by Overhydration

Cameron I. Wells, John L. McCall, Lindsay D. Plank – 24 July 2018 – Sarcopenia as defined by reduced skeletal muscle area (SMA) on cross‐sectional abdominal imaging has been proposed as an objective measure of malnutrition, and it is associated with both wait‐list mortality and posttransplant complications in patients with cirrhosis. SMA, however, has never been validated against the gold standard measurement of total body protein (TBP) by in vivo neutron activation analysis (IVNAA).

The Reactive Oxygen Species–Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia/Reperfusion Injury

Ricky H. Bhogal, Christopher J. Weston, Susanne Velduis, Henri G. D. Leuvenink, Gary M. Reynolds, Scott Davies, Luu Nyguet‐Thin, Mohammed Alfaifi, Emma L. Shepard, Yuri Boteon, Lorraine Wallace, Ye H. Oo, David H. Adams, Darius F. Mirza, Hynek Mergental, Gillian Muirhead, Barnaby T. F. Stephenson, Simon C. Afford – 24 July 2018 – Ischemia/reperfusion injury (IRI) is the main cause of complications following liver transplantation. Reactive oxygen species (ROS) were thought to be the main regulators of IRI.

Prognostic Significance of Controlled Attenuation Parameter in Patients With Compensated Advanced Chronic Liver Disease

Cristina Margini, Giuseppe Murgia, Guido Stirnimann, Andrea De Gottardi, Nasser Semmo, Stefania Casu, Jaime Bosch, Jean‐François Dufour, Annalisa Berzigotti – 24 July 2018 – Obesity and steatosis have been associated with liver disease progression in patients with compensated advanced chronic liver disease (cACLD) (liver stiffness measurement [LSM] ≥ 10 kPa). The controlled attenuation parameter (CAP) estimates steatosis during LSM by transient elastography. We aimed to evaluate whether CAP is associated with the development of clinically relevant events in cACLD.

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