A Coiled‐Coil Domain Containing 50 Splice Variant Is Modulated by Serine/Arginine‐Rich Splicing Factor 3 and Promotes Hepatocellular Carcinoma in Mice by the Ras Signaling Pathway

Hong Wang, Chris Zhiyi Zhang, Shi‐Xun Lu, Mei‐Fang Zhang, Li‐Li Liu, Rong‐Zhen Luo, Xia Yang, Chun‐Hua Wang, Shi‐Lu Chen, Yang‐Fan He, Dan Xie, Rui‐Hua Xu, Jing‐Ping Yun – 20 July 2018 – Deregulation of alternative splicing contributes to the malignant progression of cancer. Little is known about the significant alternative splicing events in hepatocellular carcinoma (HCC). High‐throughput sequencing revealed that coiled‐coil domain containing 50 (CCDC50) pre‐mRNA is aberrantly spliced in 50% of our HCC cases.

Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Posthepatectomy Liver Failure

Harvey S. Chen, Dong Jin Joo, Mohammed Shaheen, Yi Li, Yujia Wang, Jian Yang, Clara T. Nicolas, Kelly Predmore, Bruce Amiot, Gregory Michalak, Taofic Mounajjed, Jeff Fidler, Walter K. Kremers, Scott L. Nyberg – 19 July 2018 – Acute liver failure (ALF) is a catastrophic condition that can occur after major liver resection. The aim of this study was to determine the effects of the spheroid reservoir bio‐artificial liver (SRBAL) on survival, serum chemistry, and liver regeneration in posthepatectomy ALF pigs.

Liver Grafts From Donors After Circulatory Death on Regional Perfusion With Extended Warm Ischemia Compared With Donors After Brain Death

Riccardo De Carlis, Stefano Di Sandro, Andrea Lauterio, Francesca Botta, Fabio Ferla, Enzo Andorno, Vincenzo Bagnardi, Luciano De Carlis – 19 July 2018 – Donation after circulatory death (DCD) in Italy constitutes a relatively unique population because of the requirement of a no‐touch period of 20 minutes.

Impact of Abdominal Aortic Calcification Among Liver Transplantation Recipients

Yuki Imaoka, Masahiro Ohira, Ryosuke Nakano, Seiichi Shimizu, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan – 18 July 2018 – Abdominal aortic calcification (AAC) is known as a risk factor of coronary artery disease, stroke, hyperphosphatemia, chronic inflammation, diabetes, and decreased estimated glomerular filtration rate. However, the clinical implications of incidental AAC findings in liver transplantation (LT) have not been evaluated in terms of posttransplantation survival and complications.

Predictive Factors for Survival in Children Receiving Liver Transplants for Wilson’s Disease: A Cohort Study Using European Liver Transplant Registry Data

Eva‐Doreen Pfister, André Karch, René Adam, Wojciech G. Polak, Vincent Karam, Darius Mirza, John O’Grady, Jürgen Klempnauer, Raymond Reding, Piotr Kalicinski, Ahmet Coker, Pavel Trunecka, Ibrahim Astarcioglu, Emmanual Jacquemin, Johann Pratschke, Andreas Paul, Irinel Popescu, Stefan Schneeberger, Oliver Boillot, Lutz Fischer, Rafael T.

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