Caitlin J. VanLith, Rebekah M. Guthman, Clara T. Nicolas, Kari L. Allen, Yuanhang Liu, Jennifer A. Chilton, Zachariah P. Tritz, Scott L. Nyberg, Robert A. Kaiser, Joseph B. Lillegard, Raymond D. Hickey – 15 February 2019 – Ex vivo CRISPR/Cas9‐mediated gene editing in hepatocytes using homology‐directed repair (HDR) is a potential alternative curative therapy to organ transplantation for metabolic liver disease.

Victor Chiu, Rachel Hogen, Linda Sher, Niquelle Wadé, David Conti, Anastasia Martynova, Hongtao Li, Gangning Liang, Casey O'Connell – 14 February 2019 – Telomeres are repetitive DNA sequences that protect the ends of linear chromosomes, and they are maintained by a ribonucleoprotein complex called telomerase. Variants in genes encoding for telomerase components have been associated with a spectrum of disease in the lung, skin, bone marrow, and liver.

Markus Peck‐Radosavljevic, Krzysztof Simon, Angelo Iacobellis, Tarek Hassanein, Zeid Kayali, Albert Tran, Mihaly Makara, Ziv Ben Ari, Marius Braun, Paul Mitrut, Sheng‐Shun Yang, Meral Akdogan, Mario Pirisi, Ajay Duggal, Toshimitsu Ochiai, Tomoko Motomiya, Takeshi Kano, Tsutae Nagata, Nezam Afdhal – 14 February 2019 – Thrombocytopenia may be associated with increased bleeding risk impacting timing and outcome of invasive procedures in patients with chronic liver disease (CLD).

Anna S. Lok, William G. Powderly – 14 February 2019

Ludan Zhao, Yinhua Jin, Katie Donahue, Margaret Tsui, Matt Fish, Catriona Y. Logan, Bruce Wang, Roel Nusse – 14 February 2019 – In the liver, Wnt/β‐catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis. We examined Wnt gene expression and signaling after injury, and we show by in situ hybridization that Wnts are activated by acute carbon tetrachloride (CCl4) toxicity. Following injury, peri‐injury hepatocytes become Wnt‐responsive, expressing the Wnt target gene axis inhibition protein 2 (Axin2).

Shih‐Wei Lai, Cheng‐Li Lin – 14 February 2019

Rosalie C. Oey, Laurelle van Tilburg, Nicole S. Erler, Herold J. Metselaar, Manon C.W. Spaander, Henk R. van Buuren, Robert A. de Man – 14 February 2019 – Colorectal cancer (CRC) screening with colonoscopy is commonly used in patients who are candidates for liver transplantation. We initiated this study to define the risk‐benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre–liver transplantation screening between 2004 and 2017 was conducted.

Mindie H. Nguyen – 14 February 2019

Wen Wen, Robert F. Schwabe – 14 February 2019

Aysel Ünlüsoy Aksu, Subhash K. Das, Carol Nelson‐Williams, Dhanpat Jain, Ferda Özbay Hoşnut, Gülseren Evirgen Şahin, Richard P. Lifton, Silvia Vilarinho – 13 February 2019 – Undiagnosed liver disease remains an unmet medical need in pediatric hepatology, including children with high gamma‐glutamyltransferase (GGT) cholestasis. Here, we report whole‐exome sequencing of germline DNA from 2 unrelated children, both offspring of consanguineous union, with neonatal cholestasis and high GGT of unclear etiology.