| AASLD

Home

Revisiting the Paradox of Interferon‐Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later

Read more about Revisiting the Paradox of Interferon‐Stimulated Gene Expression as a Predictor of Hepatitis C Virus Treatment Response, a Decade Later

Lucy Golden‐Mason, Hugo R. Rosen – 28 July 2018

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Read more about FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Wenhui Li, Yanjun Li, Sami Siraj, Haojie Jin, Yuyuan Fan, Xinrong Yang, Xiaowu Huang, Xiaohui Wang, Jun Wang, Lei Liu, Lei Du, Quan Chen – 27 July 2018 – Mitochondria lie at the heart of innate immunity, and aberrant mitochondrial activity contributes to immune activation and chronic inflammatory diseases, including liver cancers. Mitophagy is a selective process for removing dysfunctional mitochondria. The link between mitophagy and inflammation in tumorigenesis remains largely unexplored.

Impact of Variant Donor Hepatic Arterial Anatomy on Clinical Graft Outcomes in Liver Transplantation

Read more about Impact of Variant Donor Hepatic Arterial Anatomy on Clinical Graft Outcomes in Liver Transplantation

Joel R. Schroering, Chandrashekhar A. Kubal, Jonathan A. Fridell, Taylor J. Hathaway, Ross C. Robinson, Richard S. Mangus – 27 July 2018

Schistosoma mansoni Egg–Secreted Antigens Activate Hepatocellular Carcinoma–Associated Transcription Factors c‐Jun and STAT3 in Hamster and Human Hepatocytes

Read more about Schistosoma mansoni Egg–Secreted Antigens Activate Hepatocellular Carcinoma–Associated Transcription Factors c‐Jun and STAT3 in Hamster and Human Hepatocytes

Martin Roderfeld, Sevinc Padem, Jakob Lichtenberger, Thomas Quack, Ralf Weiskirchen, Thomas Longerich, Gabriele Schramm, Yuri Churin, Karuna Irungbam, Annette Tschuschner, Anita Windhorst, Christoph G. Grevelding, Elke Roeb – 27 July 2018 – Clinical data have provided evidence that schistosomiasis can promote hepatocellular carcinogenesis. c‐Jun and STAT3 are critical regulators of liver cancer development and progression. The aim of the present study was to investigate the hepatocellular activation of c‐Jun and STAT3 by Schistosoma mansoni infection.