Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

Morgan Preziosi, Hirohisa Okabe, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga – 21 June 2018 – β‐Catenin in hepatocytes, under the control of Wnts, regulates pericentral gene expression. It also contributes to liver regeneration (LR) after partial hepatectomy (PH) by regulating cyclin‐D1 gene expression as shown in the β‐catenin and Wnt coreceptors low‐density lipoprotein receptor‐related protein 5/6 conditional knockouts (KO).

Endothelial Wnts regulate β‐catenin signaling in murine liver zonation and regeneration: A sequel to the Wnt–Wnt situation

Morgan Preziosi, Hirohisa Okabe, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga – 21 June 2018 – β‐Catenin in hepatocytes, under the control of Wnts, regulates pericentral gene expression. It also contributes to liver regeneration (LR) after partial hepatectomy (PH) by regulating cyclin‐D1 gene expression as shown in the β‐catenin and Wnt coreceptors low‐density lipoprotein receptor‐related protein 5/6 conditional knockouts (KO).

Pro: Steroids Can Be Withdrawn After Transplant in Recipients With Autoimmune Hepatitis

Avash Kalra, James R. Burton, Lisa M. Forman – 19 June 2018 – Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid‐free options, resulting in most transplant centers weaning steroids after transplant within days to months—an evidence‐based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids.

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

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