Morgan Preziosi, Hirohisa Okabe, Minakshi Poddar, Sucha Singh, Satdarshan P. Monga – 21 June 2018 – β‐Catenin in hepatocytes, under the control of Wnts, regulates pericentral gene expression. It also contributes to liver regeneration (LR) after partial hepatectomy (PH) by regulating cyclin‐D1 gene expression as shown in the β‐catenin and Wnt coreceptors low‐density lipoprotein receptor‐related protein 5/6 conditional knockouts (KO).

René Adam, Valérie Cailliez, Dorry L. Segev, Vincent Karam – 19 June 2018

Avash Kalra, James R. Burton, Lisa M. Forman – 19 June 2018 – Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid‐free options, resulting in most transplant centers weaning steroids after transplant within days to months—an evidence‐based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids.

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

Gin‐Ho Lo – 14 June 2018

Melanie Tran, Yanjun Liu, Wendong Huang, Li Wang – 14 June 2018 – The nuclear receptor superfamily contains important transcriptional regulators that play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. Many nuclear receptors are ligand‐activated transcription factors that regulate the expression of their target genes by modulating transcriptional activities and epigenetic changes.

Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Osamu Yokosuka, Naoya Kato – 14 June 2018

Yohei Mano, Tomoharu Yoshizumi, Kyohei Yugawa, Masafumi Ohira, Takashi Motomura, Takeo Toshima, Shinji Itoh, Noboru Harada, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara – 12 June 2018 – Recent studies revealed that systemic inflammation was correlated with poorer prognosis in various cancers. We investigated the prognostic value of the lymphocyte‐to‐monocyte ratio (LMR) in patients who underwent living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). We retrospectively analyzed the records of 216 patients who underwent LDLT for HCC.

Sanae Hayashi, Anis Khan, Brenna C. Simons, Chriss Homan, Takeshi Matsui, Kenji Ogawa, Keigo Kawashima, Shuko Murakami, Satoru Takahashi, Masanori Isogawa, Kazuho Ikeo, Masashi Mizokami, Brian J. McMahon, Yasuhito Tanaka – 12 June 2018 – Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long‐term serial samples from 20 HCC patients with HBV infection.