Hepatic fibrosis: Avenues of investigation and clinical implications
Jessica E.S. Shay, James P. Hamilton – 5 June 2018
Risk factors, scoring systems, and interventions for alcohol relapse after liver transplantation for alcoholic liver disease
Jane Lim, Vinay Sundaram – 5 June 2018
CON (“The window is closed”): In patients with cirrhosis with ascites, the clinical risks of nonselective beta‐blocker outweigh the benefits and should NOT be prescribed
Ariel W. Aday, Nicole E. Rich, Arjmand R. Mufti, Shannan R. Tujios – 5 June 2018
Treatment of the extrahepatic manifestations of chronic hepatitis C infection
Karn Wijarnpreecha, Wisit Cheungpasitporn, Surakit Pungpapong, Kiran R. Nakkala – 5 June 2018
Issue Information
1 June 2018
Coagulation Failure in Patients With Acute‐on‐Chronic Liver Failure and Decompensated Cirrhosis: Beyond the International Normalized Ratio
Annabel Blasi, Andrea Calvo, Verónica Prado, Enric Reverter, Juan Carlos Reverter, María Hernández‐Tejero, Fátima Aziz, Alex Amoros, Andres Cardenas, Javier Fernández – 23 May 2018 – Balanced hemostasis with hypocoagulable and hypercoagulable features may occur in acute‐on‐chronic liver failure (ACLF). The characteristics and prognostic impact of the coagulation profile in ACLF are unknown. Consecutive patients with ACLF (n = 36) and acute decompensation (AD; n = 24) were included. Blood samples for thromboelastometry (TE) were obtained at admission and 72 hours thereafter.
The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling
Marcel Klingenberg, Matthias Groß, Ashish Goyal, Maria Polycarpou‐Schwarz, Thilo Miersch, Anne‐Sophie Ernst, Jörg Leupold, Nitin Patil, Uwe Warnken, Heike Allgayer, Thomas Longerich, Peter Schirmacher, Michael Boutros, Sven Diederichs – 23 May 2018 – The identification of viability‐associated long noncoding RNAs (lncRNAs) might be a promising rationale for new therapeutic approaches in liver cancer. Here, we applied an RNA interference screening approach in hepatocellular carcinoma (HCC) cell lines to find viability‐associated lncRNAs.
Pay It Forward: Building Capacity to Treat Hepatitis C by Training Our Own Residents
- Read more about Pay It Forward: Building Capacity to Treat Hepatitis C by Training Our Own Residents
Thomas Couri, Tanmayi Gupta, George Weyer, Andrew Aronsohn – 23 May 2018
The Long Noncoding RNA Cancer Susceptibility 9 and RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein L Form a Complex and Coregulate Genes Linked to AKT Signaling
Marcel Klingenberg, Matthias Groß, Ashish Goyal, Maria Polycarpou‐Schwarz, Thilo Miersch, Anne‐Sophie Ernst, Jörg Leupold, Nitin Patil, Uwe Warnken, Heike Allgayer, Thomas Longerich, Peter Schirmacher, Michael Boutros, Sven Diederichs – 23 May 2018 – The identification of viability‐associated long noncoding RNAs (lncRNAs) might be a promising rationale for new therapeutic approaches in liver cancer. Here, we applied an RNA interference screening approach in hepatocellular carcinoma (HCC) cell lines to find viability‐associated lncRNAs.
Acetyl‐CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents
Leigh Goedeke, Jamie Bates, Daniel F. Vatner, Rachel J. Perry, Ting Wang, Ricardo Ramirez, Li Li, Matthew W. Ellis, Dongyan Zhang, Kari E. Wong, Carine Beysen, Gary W. Cline, Adrian S. Ray, Gerald I. Shulman – 23 May 2018 – Pharmacologic inhibition of acetyl‐CoA carboxylase (ACC) enzymes, ACC1 and ACC2, offers an attractive therapeutic strategy for nonalcoholic fatty liver disease (NAFLD) through simultaneous inhibition of fatty acid synthesis and stimulation of fatty acid oxidation.