Peng Sun, Yue‐Xin Lu, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Xiaozhan Wang, Yu‐Feng Yuan, Yi‐Da Tang – 9 May 2018 – Sterile inflammation is an essential factor causing hepatic ischemia/reperfusion (I/R) injury. As a critical regulator of inflammation, the role of monocyte chemoattractant protein‐induced protein 1 (MCPIP1) in hepatic I/R injury remains undetermined. In this study, we discovered that MCPIP1 downregulation was associated with hepatic I/R injury in liver transplant patients and a mouse model.

Keiichi Fujiwara, Shin Yasui, Osamu Yokosuka, Shigeto Oda, Naoya Kato – 7 May 2018

Yuanjie Pang, Christiana Kartsonaki, Iain Turnbull, Yu Guo, Robert Clarke, Yiping Chen, Fiona Bragg, Ling Yang, Zheng Bian, Iona Y. Millwood, Juanzhi Hao, Xianyong Han, Yajing Zang, Junshi Chen, Liming Li, Michael V. Holmes, Zhengming Chen – 7 May 2018 – The prevalence of diabetes is increasing rapidly in China. However, evidence is limited about its effects on chronic liver diseases and liver cancer.

Nora Winkler, Felix Strübing, Wolfgang Groß, Walter Mier, Eduard Ryschich – 7 May 2018 – The systemic drug circulation represents a source of adverse effects during tumor targeting. We studied the binding efficacy of endothelium‐specific antibodies after a very short contact with an antigen target, along with assessing the intravascular capture and targeting potential of these antibodies after locoregional injection. Fast‐binding anti–CD 146 (clone ME‐9F1) and anti‐CD31 (clone 390) antibodies were selected based on histological analysis of their binding activity.

Yuanjie Pang, Christiana Kartsonaki, Iain Turnbull, Yu Guo, Robert Clarke, Yiping Chen, Fiona Bragg, Ling Yang, Zheng Bian, Iona Y. Millwood, Juanzhi Hao, Xianyong Han, Yajing Zang, Junshi Chen, Liming Li, Michael V. Holmes, Zhengming Chen – 7 May 2018 – The prevalence of diabetes is increasing rapidly in China. However, evidence is limited about its effects on chronic liver diseases and liver cancer.

Emily K. Butler, Jeffrey Gersch, Anne McNamara, Ka‐Cheung Luk, Vera Holzmayer, Maria de Medina, Eugene Schiff, Mary Kuhns, Gavin A. Cloherty – 7 May 2018 – Treatment of chronic hepatitis B (CHB) patients with nucleos(t)ide analogs (NAs) suppresses hepatitis B virus (HBV) DNA synthesis but does not affect synthesis of HBV pregenomic RNA (pgRNA). Hepatitis B virus pgRNA is detectable in the serum during NA treatment and has been proposed as a marker of HBV covalently closed circular DNA activity within the infected hepatocyte.

Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu‐Feng Yuan, Yi‐Da Tang – 5 May 2018 – The rapidly increasing prevalence of metabolic disorders associated with nonalcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanisms to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process.

Siqi Gao, Robert Silasi‐Mansat, Amanda R. Behar, Florea Lupu, Courtney T. Griffin – 5 May 2018 – The serine protease plasmin degrades extracellular matrix (ECM) components both directly and indirectly through activation of matrix metalloproteinases. Excessive plasmin activity and subsequent ECM degradation cause hepatic sinusoidal fragility and hemorrhage in developing embryos. We report here that excessive plasmin activity in a murine acetaminophen (APAP) overdose model likewise compromises hepatic sinusoidal vascular integrity in adult animals.

Conghui Wang, Yuqiang Cheng, Xiuping Zhang, Nan Li, Lin Zhang, Shengdian Wang, Xuemei Tong, Ying Xu, Guo‐qiang Chen, Shuqun Cheng, Xuemei Fan, Junling Liu – 5 May 2018 – Polarity defects are frequently involved in liver diseases, such as chronic hepatitis and hepatocellular carcinoma (HCC). It was reported that vacuolar protein sorting 33B (Vps33b) plays critical roles in the maintenance of hepatocyte polarity; however, the functional roles and mechanisms of Vps33b in HCC occurrence and progression remain unknown.

Catherine Properzi, Therese A. O'Sullivan, Jill L. Sherriff, Helena L. Ching, Garry P. Jeffrey, Rachel F. Buckley, Jonathan Tibballs, Gerry C. MacQuillan, George Garas, Leon A. Adams – 5 May 2018 – Although diet‐induced weight loss is first‐line treatment for patients with nonalcoholic fatty liver disease (NAFLD), long‐term maintenance is difficult. The optimal diet for improvement in either NAFLD or associated cardiometabolic risk factors, regardless of weight loss, is unknown.