Huixia Zhang, Chao Zhang, Hong Tang, Shanshan Gao, Fang Sun, Yuan Yang, Weiping Zhou, Yu Hu, Changshu Ke, Yu Wu, Zeyang Ding, Lin Guo, Rongjuan Pei, Xinwen Chen, Man‐Sun Sy, Bixiang Zhang, Chaoyang Li – 5 May 2018 – Chronic hepatitis C virus (HCV) infection can result in steatosis, a condition displaying aberrant accumulation of neutral lipid vesicles, the component of lipid droplets (LDs), which are essential for HCV assembly. However, the interplay between HCV infection and steatosis remains unclear.

Theodore H. Welling, Kevin Eddinger, Kristen Carrier, Danting Zhu, Tyler Kleaveland, Derek E. Moore, Douglas E. Schaubel, Peter L. Abt – 5 May 2018 – Orthotopic liver transplantation (OLT) and resection are effective treatments for hepatocellular carcinoma (HCC). However, optimizing OLT and limiting HCC recurrence remains a vexing problem. New HCC Model for End‐Stage Liver Disease and allocation algorithms provide greater observation of HCC patients, many while receiving local‐regional treatments.

Sarah Raevens, Michael B. Fallon – 5 May 2018 – Hepatopulmonary syndrome (HPS) is a relatively common and potentially severe pulmonary complication of cirrhosis with increased risk of mortality. In experimental models, a complex interaction between pulmonary endothelial cells, monocytes, and the respiratory epithelium, which produces chemokines, cytokines, and angiogenic growth factors, causes alterations in the alveolar microvasculature, resulting in impaired oxygenation.

Rebeca Mayo, Javier Crespo, Ibon Martínez‐Arranz, Jesus M Banales, Mayte Arias, Itziar Mincholé, Rocío Aller de la Fuente, Raúl Jimenez‐Agüero, Cristina Alonso, Daniel A. de Luis, Libor Vitek, Jan Stritesky, Joan Caballería, Manuel Romero‐Gómez, Antonio Martín‐Duce, Jose Maria Mugüerza Huguet, José Ignacio Busteros‐Moraza, Michael O. Idowu, Azucena Castro, M. Luz Martínez‐Chantar, Pablo Ortiz, Radan Bruha, Shelly C. Lu, Pierre Bedossa, Mazen Noureddin, Arun J. Sanyal, José M.

Moira B. Hilscher, James H. Tabibian, Elizabeth J. Carey, Christopher J. Gostout, Keith D. Lindor – 4 May 2018 – Dominant strictures (DSs) of the biliary tree occur in approximately 50% of patients with primary sclerosing cholangitis (PSC) and may cause significant morbidity. Nevertheless, the definition and management of DSs lacks consensus. We aimed to better understand current perceptions and practices regarding PSC‐associated DSs.

Dong‐Hwan Jung, Eunyoung Tak, Shin Hwang, Gi‐Won Song, Chul‐Soo Ahn, Ki‐Hun Kim, Deok‐Bog Moon, Tae‐Yong Ha, Gil‐Chun Park, Baek‐Yeol Ryoo, Kyung Jin Lee, Nayoung Kim, Jae‐Hyeon Kwon, Eun‐Kyoung Jwa, Sung‐Gyu Lee – 30 April 2018 – Both sorafenib and mammalian target of rapamycin inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their antitumor effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence.

Siyuan Yao, Toshimi Kaido, Ryuji Uozumi, Shintaro Yagi, Yosuke Miyachi, Ken Fukumitsu, Takayuki Anazawa, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto – 30 April 2018 – There is a consensus that portal venous pressure (PVP) modulation prevents portal hypertension (PHT) and consequent complications after adult‐to‐adult living donor liver transplantation (ALDLT). However, PVP‐modulation strategies need to be updated based on the most recent findings.

Hawwa Alao, Maggie Cam, Chithra Keembiyehetty, Fang Zhang, Elisavet Serti, Daniel Suarez, Heiyoung Park, Nicolaas H. Fourie, Elizabeth C. Wright, Wendy A. Henderson, Qisheng Li, T. Jake Liang, Barbara Rehermann, Marc G. Ghany – 27 April 2018 – Hepatitis C virus (HCV) infection induces interferon (IFN)‐stimulated genes (ISGs) and downstream innate immune responses. This study investigated whether baseline and on‐treatment differences in these responses predict response versus virological breakthrough during therapy with direct‐acting antivirals (DAAs).

Shilpa Chokshi – 27 April 2018

Qing Liang, Zeyuan Liu, Chao Zhu, Bin Wang, Xiaoke Liu, Yanan Yang, Xue Lv, Haiyu Mu, Kejia Wang – 27 April 2018 – T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) immune repertoire is closely associated with the host immune response and regenerative proliferation. High‐throughput sequencing of TCR provides deep insight into monitoring the immune microenvironment. Here, we aimed to determine the role of the TCRβ immune repertoire in liver regeneration (LR).