Chiara Mazzarelli, Wendy M. Prentice, Michael A. Heneghan, Luca S. Belli, Kosh Agarwal, Mary D. Cannon – 5 May 2018 – Optimal involvement of palliative care (PC) services in the management of patients with decompensated cirrhosis and end‐stage liver disease (ESLD) is limited. This may result from both ignorance and the failure to recognize the spectrum and unpredictability of the underlying liver condition.
Catherine Properzi, Therese A. O'Sullivan, Jill L. Sherriff, Helena L. Ching, Garry P. Jeffrey, Rachel F. Buckley, Jonathan Tibballs, Gerry C. MacQuillan, George Garas, Leon A. Adams – 5 May 2018 – Although diet‐induced weight loss is first‐line treatment for patients with nonalcoholic fatty liver disease (NAFLD), long‐term maintenance is difficult. The optimal diet for improvement in either NAFLD or associated cardiometabolic risk factors, regardless of weight loss, is unknown.
Conghui Wang, Yuqiang Cheng, Xiuping Zhang, Nan Li, Lin Zhang, Shengdian Wang, Xuemei Tong, Ying Xu, Guo‐qiang Chen, Shuqun Cheng, Xuemei Fan, Junling Liu – 5 May 2018 – Polarity defects are frequently involved in liver diseases, such as chronic hepatitis and hepatocellular carcinoma (HCC). It was reported that vacuolar protein sorting 33B (Vps33b) plays critical roles in the maintenance of hepatocyte polarity; however, the functional roles and mechanisms of Vps33b in HCC occurrence and progression remain unknown.
Siqi Gao, Robert Silasi‐Mansat, Amanda R. Behar, Florea Lupu, Courtney T. Griffin – 5 May 2018 – The serine protease plasmin degrades extracellular matrix (ECM) components both directly and indirectly through activation of matrix metalloproteinases. Excessive plasmin activity and subsequent ECM degradation cause hepatic sinusoidal fragility and hemorrhage in developing embryos. We report here that excessive plasmin activity in a murine acetaminophen (APAP) overdose model likewise compromises hepatic sinusoidal vascular integrity in adult animals.
Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu‐Feng Yuan, Yi‐Da Tang – 5 May 2018 – The rapidly increasing prevalence of metabolic disorders associated with nonalcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanisms to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process.
Moira B. Hilscher, James H. Tabibian, Elizabeth J. Carey, Christopher J. Gostout, Keith D. Lindor – 4 May 2018 – Dominant strictures (DSs) of the biliary tree occur in approximately 50% of patients with primary sclerosing cholangitis (PSC) and may cause significant morbidity. Nevertheless, the definition and management of DSs lacks consensus. We aimed to better understand current perceptions and practices regarding PSC‐associated DSs.
Rebeca Mayo, Javier Crespo, Ibon Martínez‐Arranz, Jesus M Banales, Mayte Arias, Itziar Mincholé, Rocío Aller de la Fuente, Raúl Jimenez‐Agüero, Cristina Alonso, Daniel A. de Luis, Libor Vitek, Jan Stritesky, Joan Caballería, Manuel Romero‐Gómez, Antonio Martín‐Duce, Jose Maria Mugüerza Huguet, José Ignacio Busteros‐Moraza, Michael O. Idowu, Azucena Castro, M. Luz Martínez‐Chantar, Pablo Ortiz, Radan Bruha, Shelly C. Lu, Pierre Bedossa, Mazen Noureddin, Arun J. Sanyal, José M.
Siyuan Yao, Toshimi Kaido, Ryuji Uozumi, Shintaro Yagi, Yosuke Miyachi, Ken Fukumitsu, Takayuki Anazawa, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto – 30 April 2018 – There is a consensus that portal venous pressure (PVP) modulation prevents portal hypertension (PHT) and consequent complications after adult‐to‐adult living donor liver transplantation (ALDLT). However, PVP‐modulation strategies need to be updated based on the most recent findings.
Dong‐Hwan Jung, Eunyoung Tak, Shin Hwang, Gi‐Won Song, Chul‐Soo Ahn, Ki‐Hun Kim, Deok‐Bog Moon, Tae‐Yong Ha, Gil‐Chun Park, Baek‐Yeol Ryoo, Kyung Jin Lee, Nayoung Kim, Jae‐Hyeon Kwon, Eun‐Kyoung Jwa, Sung‐Gyu Lee – 30 April 2018 – Both sorafenib and mammalian target of rapamycin inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their antitumor effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence.
Chang‐Jiang Yu, Qiu‐Shi Wang, Ming‐Ming Wu, Bin‐Lin Song, Chen Liang, Jie Lou, Liang‐Liang Tang, Xiao‐Di Yu, Na Niu, Xu Yang, Bao‐Long Zhang, Yao Qu, Yang Liu, Zhi‐Chao Dong, Zhi‐Ren Zhang – 27 April 2018 – There is no effective treatment method for nonalcoholic fatty liver disease (NAFLD), the most common liver disease. The exact mechanism underlying the pathogenesis of NAFLD remains to be elucidated.