Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma

Haoyu Sun, Qiang Huang, Mei Huang, Hao Wen, Renyong Lin, Meijuan Zheng, Kun Qu, Kun Li, Haiming Wei, Weihua Xiao, Rui Sun, Zhigang Tian, Cheng Sun – 8 November 2018 – Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between three receptors fine‐tunes immune responses against tumors.

The Epidermal Growth Factor Receptor Ligand Amphiregulin Protects From Cholestatic Liver Injury and Regulates Bile Acids Synthesis

Eva Santamaría, Carlos M. Rodríguez‐Ortigosa, Iker Uriarte, Maria U. Latasa, Raquel Urtasun, Gloria Alvarez‐Sola, Marina Bárcena‐Varela, Leticia Colyn, Sara Arcelus, Maddalen Jiménez, Kathleen Deutschmann, Ana Peleteiro‐Vigil, Julian Gómez‐Cambronero, Malgorzata Milkiewicz, Piotr Milkiewicz, Bruno Sangro, Verena Keitel, Maria J. Monte, Jose J.G. Marin, Maite G. Fernández‐Barrena, Matias A. Ávila, Carmen Berasain – 8 November 2018 – Intrahepatic accumulation of bile acids (BAs) causes hepatocellular injury.

Estimating Prevalence of Hepatitis C Virus Infection in the United States, 2013‐2016

Megan G. Hofmeister, Elizabeth M. Rosenthal, Laurie K. Barker, Eli S. Rosenberg, Meredith A. Barranco, Eric W. Hall, Brian R. Edlin, Jonathan Mermin, John W. Ward, A. Blythe Ryerson – 6 November 2018 – Hepatitis C virus (HCV) infection is the most commonly reported bloodborne infection in the United States, causing substantial morbidity and mortality and costing billions of dollars annually.

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