Preemptive Activation of the Integrated Stress Response Protects Mice From Diet‐Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction

Xu Xu, Christopher Krumm, Jae‐Seon So, Curtis J. Bare, Corey Holman, Jesper Gromada, David E. Cohen, Ann‐Hwee Lee – 26 April 2018 – Integrated stress response (ISR) is a signaling system in which phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by stress‐specific kinases and subsequent activation of activation transcription factor (ATF) 4 help restore cellular homeostasis following exposure to environmental stresses.

Strategies That Reduce 90‐Day Readmissions and Inpatient Costs After Liver Transplantation

Joseph H. Zeidan, David M. Levi, Ruth Pierce, Mark W. Russo – 25 April 2018 – Liver transplantation (LT) is hospital‐resource intensive and associated with high rates of readmission. We have previously shown a reduction in 30‐day readmission rates by implementing a specifically designed protocol to increase access to outpatient care. The aim of this work is to determine if the strategies that reduce 30‐day readmission after LT were effective in also reducing 90‐day readmission rates and costs.

Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease

Paola Dongiovanni, Marica Meroni, Rosellina M. Mancina, Guido Baselli, Raffaela Rametta, Serena Pelusi, Ville Männistö, Anna L. Fracanzani, Sara Badiali, Luca Miele, Stefania Grimaudo, Salvatore Petta, Elisabetta Bugianesi, Giorgio Soardo, Silvia Fargion, Jussi Pihlajamäki, Stefano Romeo, Luca Valenti – 25 April 2018 – Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver damage and has a strong genetic component.

LiverLearning®: 2018 Webinar: Role of Diet and Exercise in the Management of NAFLD

In this webinar, we will review the role of diet and exercise in the management of NAFLD. Specifically, we will overview the data in support of specific nutritional programs and physical activity regimens that have been shown to improve histologic components of NAFLD and NASH. Lastly, we will outline the remaining knowledge gaps and barriers related to lifestyle interventions in the treatment of NAFLD/NASH.Michelle Long Michelle T.

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