Telomerase reverse transcriptase mutations in plasma DNA in patients with hepatocellular carcinoma or cirrhosis: Prevalence and risk factors

Jingjing Jiao, Gordon P. Watt, Heather L. Stevenson, Tiffany L. Calderone, Susan P. Fisher‐Hoch, Yuanqing Ye, Xifeng Wu, John M. Vierling, Laura Beretta – 27 April 2018 – Telomerase reverse transcriptase (TERT) mutation is the most frequent genetic alteration in hepatocellular carcinoma (HCC). Our aims were to investigate whether TERT mutations can be detected in circulating cell‐free DNA (cfDNA) of patients with HCC and/or cirrhosis and characterize clinical parameters associated with these mutations.

Intrahepatic T‐Cell Receptor β Immune Repertoire Is Essential for Liver Regeneration

Qing Liang, Zeyuan Liu, Chao Zhu, Bin Wang, Xiaoke Liu, Yanan Yang, Xue Lv, Haiyu Mu, Kejia Wang – 27 April 2018 – T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) immune repertoire is closely associated with the host immune response and regenerative proliferation. High‐throughput sequencing of TCR provides deep insight into monitoring the immune microenvironment. Here, we aimed to determine the role of the TCRβ immune repertoire in liver regeneration (LR).

Baseline Intrahepatic and Peripheral Innate Immunity are Associated with Hepatitis C Virus Clearance During Direct‐Acting Antiviral Therapy

Hawwa Alao, Maggie Cam, Chithra Keembiyehetty, Fang Zhang, Elisavet Serti, Daniel Suarez, Heiyoung Park, Nicolaas H. Fourie, Elizabeth C. Wright, Wendy A. Henderson, Qisheng Li, T. Jake Liang, Barbara Rehermann, Marc G. Ghany – 27 April 2018 – Hepatitis C virus (HCV) infection induces interferon (IFN)‐stimulated genes (ISGs) and downstream innate immune responses. This study investigated whether baseline and on‐treatment differences in these responses predict response versus virological breakthrough during therapy with direct‐acting antivirals (DAAs).

Ubiquitin‐Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6

Pengcheng Luo, Cong Qin, Lihua Zhu, Chun Fang, Yan Zhang, Hai Zhang, Fei Pei, Song Tian, Xue‐Yong Zhu, Jun Gong, Qing Mao, Chengcheng Xiao, Yang Su, Haizhou Zheng, Tao Xu, Jingxiao Lu, Jie Zhang – 26 April 2018 – Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly understood. Ubiquitin‐specific peptidase 10 (USP10), a member of the ubiquitin‐specific protease family, is involved in environmental stress responses, tumor growth, inflammation, and cellular metabolism.

Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis

Amy E. Taylor, Alexandra N. Carey, Ramesh Kudira, Celine S. Lages, Tiffany Shi, Simon Lam, Rebekah Karns, Julia Simmons, Kumar Shanmukhappa, Maha Almanan, Claire A. Chougnet, Alexander G. Miethke – 26 April 2018 – In the multidrug resistance protein 2 (Mdr2)‐/‐ mouse model, low phospholipid bile instigates biliary epithelial injury, sterile inflammation, and fibrosis, thereby recapitulating disease mechanisms implicated in biliary atresia (BA) and primary sclerosing cholangitis.

Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study

Zeeshan Butt, Andrea F. DiMartini, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan Holtzman, Daniela Ladner, Kim Olthoff, Robert A. Fisher, Silvia Hafliger, Chris E. Freise, Mercedes Susan Mandell, Averell H. Sherker, Mary Amanda Dew – 26 April 2018 – Little is known about living liver donors' perceptions of their physical well‐being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study consortium.

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