Avash Kalra, James R. Burton, Lisa M. Forman – 19 June 2018 – Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid‐free options, resulting in most transplant centers weaning steroids after transplant within days to months—an evidence‐based management decision. Patients with autoimmune hepatitis (AIH), however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids.

René Adam, Valérie Cailliez, Dorry L. Segev, Vincent Karam – 19 June 2018

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

Simon T. Hui, Zeyneb Kurt, Iina Tuominen, Frode Norheim, Richard C.Davis, Calvin Pan, Darwin L. Dirks, Clara E. Magyar, Samuel W. French, Karthickeyan Chella Krishnan, Simon Sabir, Francisco Campos‐Pérez, Nahum Méndez‐Sánchez, Luis Macías‐Kauffer, Paola León‐Mimila, Samuel Canizales‐Quinteros, Xia Yang, Simon W. Beaven, Adriana Huertas‐Vazquez, Aldons J. Lusis – 16 June 2018 – We report the genetic analysis of a “humanized” hyperlipidemic mouse model for progressive nonalcoholic steatohepatitis (NASH) and fibrosis.

Sadahisa Ogasawara, Tetsuhiro Chiba, Yoshihiko Ooka, Osamu Yokosuka, Naoya Kato – 14 June 2018

Melanie Tran, Yanjun Liu, Wendong Huang, Li Wang – 14 June 2018 – The nuclear receptor superfamily contains important transcriptional regulators that play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. Many nuclear receptors are ligand‐activated transcription factors that regulate the expression of their target genes by modulating transcriptional activities and epigenetic changes.

Gin‐Ho Lo – 14 June 2018

Eleni Theocharidou, Michael A. Heneghan – 12 June 2018 – Autoimmune liver diseases (AILDs) can recur following liver transplantation (LT) despite immunosuppressive therapy, with implications for graft survival. Although the evidence is not robust, disease recurrence seems to occur in the presence of less intense and/or steroid‐free immunosuppression (IS) in particular in the case of autoimmune hepatitis (AIH). The main risk factor for AIH recurrence is the severity of disease activity in the explant and potential donor/recipient human leukocyte antigen D‐related 3 (DR3) mismatch.

Sanae Hayashi, Anis Khan, Brenna C. Simons, Chriss Homan, Takeshi Matsui, Kenji Ogawa, Keigo Kawashima, Shuko Murakami, Satoru Takahashi, Masanori Isogawa, Kazuho Ikeo, Masashi Mizokami, Brian J. McMahon, Yasuhito Tanaka – 12 June 2018 – Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long‐term serial samples from 20 HCC patients with HBV infection.

Sanae Hayashi, Anis Khan, Brenna C. Simons, Chriss Homan, Takeshi Matsui, Kenji Ogawa, Keigo Kawashima, Shuko Murakami, Satoru Takahashi, Masanori Isogawa, Kazuho Ikeo, Masashi Mizokami, Brian J. McMahon, Yasuhito Tanaka – 12 June 2018 – Hepatitis B virus (HBV) genotype F1b infection is strongly associated with hepatocellular carcinoma (HCC) in young Alaskan Native (AN) people. However, the mechanisms by which genotype F1b causes HCC are unclear. Here, we analyzed the clinical and virological significance of genotype F1b in long‐term serial samples from 20 HCC patients with HBV infection.