This webinar will focus on best practices regarding evaluation of the patient presenting with abnormal liver enzymes. The focus will be not only on testing needed to arrive at the appropriate diagnosis, but also how to approach testing to minimize costs. This is an essential part of the daily practice for hepatologists and gastroenterologists.Vinay Sundaram (Moderator) Vinay Sundaram, MD, MSc is currently an Associate Professor of medicine and Director of Hepatology Outcomes Research at Cedars-Sinai Medical Center.

Morgan H. Randall, Mary Stoermann, Don C. Rockey – 19 April 2018

Bo Kong, Runbin Sun, Mingxing Huang, Monica D. Chow, Xiao‐Bo Zhong, Wen Xie, Yi‐Horng Lee, Grace L. Guo – 19 April 2018 – The role of intestine‐derived factors in promoting liver regeneration after partial hepatectomy (PHx) are not entirely known, but bile acids (BAs) and fibroblast growth factor 15 (Fgf15) that is highly expressed in the mouse ileum could promote hepatocyte proliferation. Fgf15 strongly suppresses the synthesis of BAs, and emerging evidence indicates that Fgf15 is important for liver regeneration.

Manhal Izzy, Jae Oh, Kymberly D. Watt – 19 April 2018 – Cirrhotic cardiomyopathy in end‐stage liver disease is currently characterized by blunted contractile systolic response to stress with or without diastolic dysfunction in the absence of known heart disease. Since the establishment of the diagnostic criteria of cirrhotic cardiomyopathy in 2005, there have been multiple studies regarding its pathophysiology and pretransplant clinical course. The data regarding the post‐transplant course of this entity are sparse.

Norah A. Terrault – 19 April 2018

Nancy Reau, Paul Y. Kwo, Susan Rhee, Robert S. Brown, Kosh Agarwal, Peter Angus, Edward Gane, Jia‐Horng Kao, Parvez S. Mantry, David Mutimer, K. Rajender Reddy, Tram T. Tran, Yiran B. Hu, Abhishek Gulati, Preethi Krishnan, Emily O. Dumas, Ariel Porcalla, Nancy S. Shulman, Wei Liu, Suvajit Samanta, Roger Trinh, Xavier Forns – 19 April 2018 – Well‐tolerated, ribavirin‐free, pangenotypic hepatitis C virus (HCV) treatments for transplant recipients remain a high priority.

George Cholankeril, Chiranjeevi Gadiparthi, Donghee Kim, Aijaz Ahmed – 19 April 2018

Jagpreet Chhatwal, Emily D. Bethea, Sumeyye Samur, Raymond T. Chung – 19 April 2018

Eunkyong Ko, Jong‐Seo Kim, Soomi Ju, Hyun‐Wook Seo, Yeonji Chang, Jung‐Ah Kang, Sung‐Gyoo Park, Guhung Jung – 19 April 2018 – Dyskerin pseudouridine synthase 1 (DKC1) is a conserved gene encoding the RNA‐binding protein dyskerin, which is an essential component of the telomerase holoenzyme. DKC1 up‐regulation is frequently observed in many different human cancers including hepatocellular carcinoma (HCC); however, its regulatory mechanisms remain unclear. Thus, we investigated the regulatory mechanism of DKC1 in HCC progression.

Marco Carbone, Maren H. Harms, Willem J. Lammers, Tonya Marmon, Richard Pencek, Leigh MacConell, David Shapiro, David E. Jones, George F. Mells, Bettina E. Hansen – 19 April 2018 – The GLOBAL Primary Biliary Cholangitis (PBC) Study Group and United Kingdom‐PBC (UK‐PBC) Consortium have demonstrated that dichotomous response criteria are not as accurate as continuous equations at predicting mortality or liver transplantation in PBC.