Caspase Recruitment Domain Protein 6 Protects Against Hepatic Steatosis and Insulin Resistance by Suppressing Apoptosis Signal–Regulating Kinase 1

Peng Sun, Qiang Zeng, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Yu‐Feng Yuan, Yi‐Da Tang – 5 May 2018 – The rapidly increasing prevalence of metabolic disorders associated with nonalcoholic fatty liver disease (NAFLD) warrants further study of the underlying mechanisms to identify key regulators as targets for the development of therapeutic interventions. Caspase recruitment domain protein 6 (Card6), as a member of the CARD family that regulates cell death and immunity, may potentially control this process.

Dominant strictures in primary sclerosing cholangitis: A multicenter survey of clinical definitions and practices

Moira B. Hilscher, James H. Tabibian, Elizabeth J. Carey, Christopher J. Gostout, Keith D. Lindor – 4 May 2018 – Dominant strictures (DSs) of the biliary tree occur in approximately 50% of patients with primary sclerosing cholangitis (PSC) and may cause significant morbidity. Nevertheless, the definition and management of DSs lacks consensus. We aimed to better understand current perceptions and practices regarding PSC‐associated DSs.

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Rebeca Mayo, Javier Crespo, Ibon Martínez‐Arranz, Jesus M Banales, Mayte Arias, Itziar Mincholé, Rocío Aller de la Fuente, Raúl Jimenez‐Agüero, Cristina Alonso, Daniel A. de Luis, Libor Vitek, Jan Stritesky, Joan Caballería, Manuel Romero‐Gómez, Antonio Martín‐Duce, Jose Maria Mugüerza Huguet, José Ignacio Busteros‐Moraza, Michael O. Idowu, Azucena Castro, M. Luz Martínez‐Chantar, Pablo Ortiz, Radan Bruha, Shelly C. Lu, Pierre Bedossa, Mazen Noureddin, Arun J. Sanyal, José M.

Is Portal Venous Pressure Modulation Still Indicated for All Recipients in Living Donor Liver Transplantation?

Siyuan Yao, Toshimi Kaido, Ryuji Uozumi, Shintaro Yagi, Yosuke Miyachi, Ken Fukumitsu, Takayuki Anazawa, Naoko Kamo, Kojiro Taura, Hideaki Okajima, Shinji Uemoto – 30 April 2018 – There is a consensus that portal venous pressure (PVP) modulation prevents portal hypertension (PHT) and consequent complications after adult‐to‐adult living donor liver transplantation (ALDLT). However, PVP‐modulation strategies need to be updated based on the most recent findings.

Antitumor effect of sorafenib and mammalian target of rapamycin inhibitor in liver transplantation recipients with hepatocellular carcinoma recurrence

Dong‐Hwan Jung, Eunyoung Tak, Shin Hwang, Gi‐Won Song, Chul‐Soo Ahn, Ki‐Hun Kim, Deok‐Bog Moon, Tae‐Yong Ha, Gil‐Chun Park, Baek‐Yeol Ryoo, Kyung Jin Lee, Nayoung Kim, Jae‐Hyeon Kwon, Eun‐Kyoung Jwa, Sung‐Gyu Lee – 30 April 2018 – Both sorafenib and mammalian target of rapamycin inhibitor (mTORi) have antitumor effects. This study aimed to evaluate their antitumor effects in liver transplantation (LT) recipients with hepatocellular carcinoma (HCC) recurrence.

TRUSS Exacerbates NAFLD Development by Promoting IκBα Degradation in Mice

Chang‐Jiang Yu, Qiu‐Shi Wang, Ming‐Ming Wu, Bin‐Lin Song, Chen Liang, Jie Lou, Liang‐Liang Tang, Xiao‐Di Yu, Na Niu, Xu Yang, Bao‐Long Zhang, Yao Qu, Yang Liu, Zhi‐Chao Dong, Zhi‐Ren Zhang – 27 April 2018 – There is no effective treatment method for nonalcoholic fatty liver disease (NAFLD), the most common liver disease. The exact mechanism underlying the pathogenesis of NAFLD remains to be elucidated.

Hepatic iron concentration correlates with insulin sensitivity in nonalcoholic fatty liver disease

Laurence Britton, Kim Bridle, Janske Reiling, Nishreen Santrampurwala, Leesa Wockner, Helena Ching, Katherine Stuart, V. Nathan Subramaniam, Gary Jeffrey, Tim St. Pierre, Michael House, Joel Gummer, Robert Trengove, John Olynyk, Darrell Crawford, Leon Adams – 27 April 2018 – Rodent and cell‐culture models support a role for iron‐related adipokine dysregulation and insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, substantial human data are lacking.

Morphological characterization of chronic antibody‐mediated rejection in ABO‐identical or ABO‐compatible pediatric liver graft recipients

Myriam Dao, Dalila Habès, Jean‐Luc Taupin, Charlotte Mussini, Marie‐José Redon, Caroline Suberbielle, Emmanuel Jacquemin, Emmanuel Gonzales, Catherine Guettier – 27 April 2018 – This study aims to define the morphological profile associated with the presence of donor‐specific antibodies (DSAs) and/or C4d immunostaining in ABO‐identical or compatible pediatric liver grafts. Ten‐year protocol liver graft biopsies performed at 131.3 ± 15.3 months after transplantation in 53 pediatric liver graft recipients were reviewed.

CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein–Coupled Receptor–Mediated Signaling in Hepatocellular Carcinoma

Yin Yin, Xiaoliang Xu, Junwei Tang, Wenjie Zhang, Guangyan Zhangyuan, Jie Ji, Lei Deng, Shuai Lu, Han Zhuo, Beicheng Sun – 27 April 2018 – Cluster of differentiation 97 (CD97) is a member of the epidermal growth factor seven‐transmembrane family belonging to the class B G protein–coupled receptors (GPCRs). The protein affects tumor aggressiveness through its cellular ligand CD55 stimulation and exhibits adhesive properties. Studies have demonstrated the involvement of CD97 in dedifferentiation, migration, invasiveness, and metastasis of tumors.

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