Chronic HBV (CHB) infection follows a dynamic course with multiple phases of disease with various durations.  ALT flares during CHB can be challenging for clinicians to manage.  In some settings ALT flares herald a transition from active to inactive disease and thus are considered to be beneficial. In other scenarios, they may indicate aggressive inflammatory liver disease than can lead to progressive liver injury or even fulminant hepatic failure.

The goal of this program is to highlight the hepatic manifestations of various diseases endemic or epidemic in the Tropics. These diseases include viral A and E hepatitis; hepatic manifestations of viral epidemics like Dengue, SARS, and Zika virus; bacterial infections like typhoid; and parasitic diseases like malaria.Kenneth Sherman Harshad Devarbhavi Maria Cassia Mendes Edna Strauss Robert Gish Robert G. Gish, MD AGAF, FAST, FAASLD is currently an Adjunct Professor of Medicine at the University of Nevada Schools of Medicine in Las Vegas and in Reno.

This half-day program provides an overview of both current and emerging therapies for common liver diseases. Additionally, it will enhance knowledge around diagnostics and highlight the roles of collaborating professionals.Yuko Kono John E. Eaton Dr. John Eaton is a transplant Hepatologist with a clinical and research focus on cholestatic liver diseases with an emphasis on primary sclerosing cholangitis (PSC) and related comorbid conditions. His clinical practice involves seeing a large volume of patients with PSC and PSC complicated by cholangiocarcinoma. Dr.

Carla Serra, Alessandro Cucchetti, Cristina Felicani, Cristina Mosconi, Antonio De Cinque, Rita Golfieri, Pietro Andreone, Giorgio Ercolani, Lorenzo Maroni, Matteo Ravaioli, Antonia D’Errico, Antonio Daniele Pinna, Matteo Cescon – 11 November 2018 – Radiofrequency ablation (RFA) represents a potentially curative option for early‐stage hepatocellular carcinoma (HCC). This study aims at evaluating the histologic response after RFA of small HCCs arising in cirrhosis. Data were reviewed from 78 patients with de novo HCCs who were treated with RFA and subsequently transplanted.

John A. Geha, Joseph D. Geha, Christine A. O’Mahony, Ronald T. Cotton, Thao N. Galvan, Abbas Rana, John A. Goss – 11 November 2018

Yanling Ma, Olga V. Belyaeva, Philip M. Brown, Koji Fujita, Katherine Valles, Suman Karki, Ynto S. de Boer, Christopher Koh, Yanhua Chen, Xiaomeng Du, Samuel K. Handelman, Vincent Chen, Elizabeth K. Speliotes, Cara Nestlerode, Emmanuel Thomas, David E. Kleiner, Joseph M. Zmuda, Arun J. Sanyal, (for the Nonalcoholic Steatohepatitis Clinical Research Network), Natalia Y. Kedishvili, T. Jake Liang, Yaron Rotman – 11 November 2018 – Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease.

This program will review the current status of liver transplantation in the setting of combined organ transplants (i.e., liver/intestine/multi-visceral, liver/ kidney, liver/heart and liver/lung transplantation). Indications, pathophysiology, operative management, post-transplant care and outcomes will be discussed in the context of specific extra-hepatic organ dysfunction and combined organ transplantation.

Leticia Muñoz, María‐José Borrero, María Úbeda, Elisa Conde, Rosa del Campo, Macarena Rodríguez‐Serrano, Margaret Lario, Ana‐María Sánchez‐Díaz, Oscar Pastor, David Díaz, Laura García‐Bermejo, Jorge Monserrat, Melchor Álvarez‐Mon, Agustín Albillos – 10 November 2018 – In cirrhosis, intestinal dysbiosis, intestinal barrier impairment, and systemic immune system abnormalities lead to gut bacterial translocation (GBT) and bacterial infection. However, intestinal immune system dysfunction and its contribution to barrier damage are poorly understood.

Sapana Verma, Subhash Gupta – 10 November 2018

Precision medicine has the potential to completely revolutionize health care research and treatment – allowing doctors and researchers to more accurately predict which treatment and prevention strategies for a particular disease will work in individual patients or groups of patients vs. a one-size-fits all paradigm.