Genotype 5 Hepatitis E Virus Produced by a Reverse Genetics System Has the Potential for Zoonotic Infection

Tian‐Cheng Li, Huimin Bai, Sayaka Yoshizaki, Yasushi Ami, Yuriko Suzaki, Yen Hai Doan, Kazuaki Takahashi, Shunji Mishiro, Naokazu Takeda, Takaji Wakita – 30 November 2018 – Neither an animal model nor a cell culture system has been established for the genotype 5 hepatitis E virus (G5 HEV), and the pathogenicity, epidemiology, and replication mechanism of the virus remain unclear. In this study, we used a reverse genetics system to generate G5 HEV and examined the possibility of zoonotic infection.

Childhood Fructoholism and Fructoholic Liver Disease

Andreia Ribeiro, Maria‐Jose Igual‐Perez, Ermelinda Santos Silva, Etienne M. Sokal – 30 November 2018 – Nonalcoholic fatty liver disease (NAFLD) is an emerging entity, becoming the most prevalent pediatric chronic liver disease. Its broad spectrum of histological findings, comorbidities, and complications, including cirrhosis and liver failure, can occur in childhood, emphasizing the severity of pediatric NAFLD.

Effect of Increasing Age on Brain Dysfunction in Cirrhosis

Runping Liu, Vishwadeep Ahluwalia, Jason D. Kang, Siddhartha S. Ghosh, Huiping Zhou, Yunzhou Li, Derrick Zhao, Emily Gurley, Xiaojiaoyang Li, Melanie B. White, Andrew Fagan, H. Robert Lippman, James B. Wade, Phillip B. Hylemon, Jasmohan S. Bajaj – 30 November 2018 – Patients with cirrhosis are growing older, which could have an impact on brain dysfunction beyond hepatic encephalopathy. Our aim was to study the effect of concomitant aging and cirrhosis on brain inflammation and degeneration using human and animal experiments.

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