A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

Hannah L. Paish, Lee H. Reed, Helen Brown, Mark C. Bryan, Olivier Govaere, Jack Leslie, Ben S. Barksby, Marina Garcia Macia, Abigail Watson, Xin Xu, Marco Y.W. Zaki, Laura Greaves, Julia Whitehall, Jeremy French, Steven A. White, Derek M. Manas, Stuart M. Robinson, Gabriele Spoletini, Clive Griffiths, Derek A. Mann, Lee A. Borthwick, Michael J.

An Advanced Practice Practitioner–Based Program to Reduce 30‐ and 90‐Day Readmissions After Liver Transplantation

Nadim Mahmud, Samantha Halpern, Rebecca Farrell, Kate Ventura, Arwin Thomasson, Heidi Lewis, Kim M. Olthoff, Matthew H. Levine, Susanna Nazarian, Vandana Khungar – 4 April 2019 – Hospital readmissions after liver transplantation (LT) are common and associated with increased morbidity and cost. High readmission rates at our center motivated a change in practice with adoption of a nurse practitioner (NP)–based posttransplant care program.

Attitudes of Liver Transplant Candidates Toward Organs From Increased‐Risk Donors

Sapna S. Humar, Jingqian Liu, Natalia Pinzon, Deepali Kumar, Mamatha Bhat, Les Lilly, Nazia Selzner – 4 April 2019 – Increased‐risk donor (IRD) organs make up a significant proportion of the deceased organ donor pool but may be declined by patients on the waiting list for various reasons. We conducted a survey of patients awaiting a liver transplant to determine the factors leading to the acceptance of an IRD organ as well as what strategies could increase the rate of acceptance.

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Megan G. Hofmeister, Brian R. Edlin, Eli S. Rosenberg, Elizabeth M. Rosenthal, Laurie K. Barker, Meredith A. Barranco, Eric W. Hall, Jonathan Mermin, A. Blythe Ryerson – 4 April 2019

Chronic Kidney Disease After Liver Transplantation: Impact of Extended Criteria Grafts

Marit Kalisvaart, Andrea Schlegel, Palak J. Trivedi, Keith Roberts, Darius F. Mirza, Thamara Perera, John I. Isaac, James Ferguson, Jeroen Jonge, Paolo Muiesan – 4 April 2019 – The use of extended criteria donor (ECD) grafts has been associated with acute kidney injury (AKI) after liver transplantation. However, the relation between graft quality and development of chronic kidney disease (CKD) remains unknown. Therefore, the aim of this study was to analyze the impact of ECD grafts for CKD after liver transplantation.

Evaluation of a Multifaceted Intervention to Reduce Health Disparities in Hepatitis C Screening: A Pre‐Post Analysis

Mamta K. Jain, Nicole E. Rich, Chul Ahn, Barbara J. Turner, Joanne M. Sanders, Brian Adamson, Lisa Quirk, Patrice Perryman, Noel O. Santini, Amit G. Singal – 4 April 2019 – Hepatitis C virus (HCV) testing in persons born from 1945 to 1965 has had limited adoption despite guidelines, particularly among racial/ethnic minorities and socioeconomically disadvantaged patients, who have a higher prevalence of disease burden. We examined the effectiveness of a multifaceted intervention to improve HCV screening in a large safety‐net health system.

The Contents of Herbal and Dietary Supplements Implicated in Liver Injury in the United States Are Frequently Mislabeled

Victor Navarro, Bharathi Avula, Ikhlas Khan, Manisha Verma, Leonard Seeff, Jose Serrano, Andrew Stolz, Robert Fontana, Jawad Ahmad – 3 April 2019 – The U.S. Drug Induced Liver Injury Network assayed the contents of herbal and dietary supplements collected from patients enrolled into its prospective study. The aim was to determine the accuracy of product labels, and to identify known hepatotoxins. Using high‐performance liquid chromatography coupled with mass spectrometry to assay 272 product, 51% were found to be mislabeled; that is, to have chemical contents that did not match the label.

A Back‐to‐Base Experience of Human Normothermic Ex Situ Liver Perfusion: Does the Chill Kill?

Mariusz Bral, Khaled Dajani, Dayne Leon Izquierdo, David Bigam, Norman Kneteman, Carlo D. L. Ceresa, Peter J. Friend, A. M. James Shapiro – 2 April 2019 – Normothermic machine perfusion (NMP) has been shown to protect livers from injury between procurement and transplantation in a randomized controlled trial, where the machine was transported to and from the donor center. The aim of this study was to determine whether an alternative, more practical back‐to‐base approach after initial static cold storage would compromise beneficial outcomes.

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