Tracking Fenestrae Dynamics in Live Murine Liver Sinusoidal Endothelial Cells
Bartlomiej Zapotoczny, Karolina Szafranska, Edyta Kus, Filip Braet, Eddie Wisse, Stefan Chlopicki, Marek Szymonski – 23 August 2018 – The fenestrae of liver sinusoidal endothelial cells (LSECs) allow passive transport of solutes, macromolecules, and particulate material between the sinusoidal lumen and the liver parenchymal cells. Until recently, fenestrae and fenestrae‐associated structures were mainly investigated using electron microscopy on chemically fixed LSECs. Hence, the knowledge about their dynamic properties has remained to date largely elusive.