A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A

Li Zhou, Ji‐Hua Ren, Sheng‐Tao Cheng, Hong‐Mei Xu, Wei‐Xian Chen, Da‐Peng Chen, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yi Liu, Xue‐Fei Cai, Hua Tang, Hai‐Bo Yu, Jie‐Li Hu, Yuan Hu, Hong‐Zhong Zhou, Fang Ren, Lin He, Zhong‐Wen Hu, Hui Jiang, Hong‐Yan Xu, Ai‐Long Huang, Juan Chen – 7 January 2019 – Hepatitis B virus (HBV) infection is a common infectious disease, in which nuclear covalently closed circular DNA (cccDNA) plays a key role in viral persistence, viral reactivation after treatment withdrawal, and drug resistance.

Hepatology Highlights

Nicholas Russo, Arun Jesudian, Nicole T. Shen, Robert S. Brown, Akiko Sugiyama, Hayley T. Nicholls, Joseph F. Pisa, Tibor I. Krisko, Russell Rosenblatt, Zaid H. Tafesh, Brett E. Fortune, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Vikas Gupta, Tasha B. Kulai, Harmeet Malhi – 7 January 2019

Early Seroreversion After 2 Doses of Hepatitis A Vaccination in Human Immunodeficiency Virus–Positive Patients: Incidence and Associated Factors

Sung‐Hsi Huang, Chung‐Hao Huang, Ning‐Chi Wang, Tun‐Chieh Chen, Yuan‐Ti Lee, Shih‐Ping Lin, Te‐Yu Lin, Chi‐Ying Lin, Yu‐Lin Lee, Chen‐Hsiang Lee, Cheng‐Pin Chen, Kuan‐Yin Lin, Guan‐Jhou Chen, Chun‐Eng Liu, Shu‐Hsing Cheng, Po‐Liang Lu, Chia‐Jui Yang, Chien‐Ching Hung, on behalf of the Taiwan HIV Study Group – 7 January 2019 – Serological responses (Seroresponse) and durability of hepatitis A virus (HAV) vaccination are reduced among human immunodeficiency virus (HIV)‐positive patients.

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

Luis Calzadilla‐Bertot, Gary P. Jeffrey, Bryon Jacques, Geoffrey McCaughan, Michael Crawford, Peter Angus, Robert Jones, Edward Gane, Stephen Munn, Graeme Macdonald, Jonathan Fawcett, Alan Wigg, John Chen, Michael Fink, Leon A. Adams – 4 January 2019 – The worldwide increase in obesity and diabetes has led to predictions that nonalcoholic steatohepatitis (NASH) will become the leading indication for orthotopic liver transplantation (OLT). Data supporting this prediction from outside the United States are limited.

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