Hepatology Highlights

Nicholas Russo, Arun Jesudian, Nicole T. Shen, Robert S. Brown, Akiko Sugiyama, Hayley T. Nicholls, Joseph F. Pisa, Tibor I. Krisko, Russell Rosenblatt, Zaid H. Tafesh, Brett E. Fortune, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Vikas Gupta, Tasha B. Kulai, Harmeet Malhi – 7 January 2019

Integrative Analysis Defines Distinct Prognostic Subgroups of Intrahepatic Cholangiocarcinoma

Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler – 7 January 2019 – Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis.

Early Seroreversion After 2 Doses of Hepatitis A Vaccination in Human Immunodeficiency Virus–Positive Patients: Incidence and Associated Factors

Sung‐Hsi Huang, Chung‐Hao Huang, Ning‐Chi Wang, Tun‐Chieh Chen, Yuan‐Ti Lee, Shih‐Ping Lin, Te‐Yu Lin, Chi‐Ying Lin, Yu‐Lin Lee, Chen‐Hsiang Lee, Cheng‐Pin Chen, Kuan‐Yin Lin, Guan‐Jhou Chen, Chun‐Eng Liu, Shu‐Hsing Cheng, Po‐Liang Lu, Chia‐Jui Yang, Chien‐Ching Hung, on behalf of the Taiwan HIV Study Group – 7 January 2019 – Serological responses (Seroresponse) and durability of hepatitis A virus (HAV) vaccination are reduced among human immunodeficiency virus (HIV)‐positive patients.

Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation and Associated Fibrosis

Zita Galvin, Ramraj Rajakumar, Emily Chen, Oyedele Adeyi, Markus Selzner, David Grant, Gonzalo Sapisochin, Paul Greig, Mark Cattral, Ian McGilvray, Anand Ghanekar, Nazia Selzner, Les Lilly, Keyur Patel, Mamatha Bhat – 4 January 2019 – Nonalcoholic fatty liver disease (NAFLD) can occur de novo in patients undergoing liver transplantation (LT) for indications other than NAFLD, and it has been increasingly recognized as a complication in the post‐LT setting.

Increasing Incidence of Nonalcoholic Steatohepatitis as an Indication for Liver Transplantation in Australia and New Zealand

Luis Calzadilla‐Bertot, Gary P. Jeffrey, Bryon Jacques, Geoffrey McCaughan, Michael Crawford, Peter Angus, Robert Jones, Edward Gane, Stephen Munn, Graeme Macdonald, Jonathan Fawcett, Alan Wigg, John Chen, Michael Fink, Leon A. Adams – 4 January 2019 – The worldwide increase in obesity and diabetes has led to predictions that nonalcoholic steatohepatitis (NASH) will become the leading indication for orthotopic liver transplantation (OLT). Data supporting this prediction from outside the United States are limited.

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