Elevated Risk of Split‐Liver grafts in adult liver Transplantation: Statistical Artifact or Nature of the Beast?

Kazunari Sasaki, Daniel J. Firl, John C. McVey, Jesse D. Schold, Giuseppe Iuppa, Teresa Diago Uso, Masato Fujiki, Federico N. Aucejo, Cristiano Quintini, Bijan Eghetsad, Charles M. Miller, Koji Hashimoto – 7 January 2019 – A recent study using US national registry data reported, using Cox proportional hazards (PH) models, that split‐liver transplantation (SLT) has improved over time and is no more hazardous than whole‐liver transplantation (WLT). However, the study methods violated the PH assumption, which is the fundamental assumption of Cox modeling.

Not All Cellular Rejections Are the Same: Differences in Early and Late Hepatic Allograft Rejection

Caroline C. Jadlowiec, Paige E. Morgan, Avinash K. Nehra, Matthew A. Hathcock, Walter K. Kremers, Julie K. Heimbach, Russell H. Wiesner, Timucin Taner – 7 January 2019 – T cell–mediated rejection (TCMR) is common after liver transplantation (LT), and it is often thought to have a minimum impact on outcomes. Because alloimmune response changes over time, we investigated the role of the timing of TCMR on patient and allograft survival and examined the risk factors for early and late TCMR. We reviewed protocol liver biopsies for 787 consecutive LT recipients with an 8.6‐year follow‐up.

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