Jan Hinrich Bräsen, Young‐Seon Mederacke, Jessica Schmitz, Kateryna Diahovets, Abedalrazag Khalifa, Björn Hartleben, Fermín Person, Thorsten Wiech, Eric Steenbergen, Anika Großhennig, Michael P. Manns, Roland Schmitt, Ingmar Mederacke – 11 January 2019 – Impairment of renal function often occurs in patients with liver disease. Hepatorenal syndrome is a significant cause of acute kidney injury (AKI) in patients with cirrhosis (HRS‐AKI, type 1). Causes of non‐HRS‐AKI include cholemic nephropathy (CN), a disease that is characterized by intratubular bile casts and tubular injury.

Naveed Z. Janjua, Maryam Darvishian, Stanley Wong, Amanda Yu, Carmine Rossi, Alnoor Ramji, Eric M. Yoshida, Zahid A. Butt, Hasina Samji, Mei Chong, Nuria Chapinal, Darrel Cook, Maria Alvarez, Mark Tyndall, Mel Krajden, the British Columbia Hepatitis Testers Cohort Team – 10 January 2019 – We evaluated the effectiveness of ledipasvir/sofosbuvir (LDV/SOF) in treating hepatitis C virus (HCV) genotype 1 and SOF/velpatasvir (SOF/VEL) for all genotypes among people who inject drugs (PWID) and those not injecting drugs and who were on or off opioid agonist therapy (OAT).

Maria Hukkinen, Jouko Lohi, Päivi Heikkilä, Reetta Kivisaari, Timo Jahnukainen, Hannu Jalanko, Mikko P. Pakarinen – 9 January 2019 – We investigated noninvasive follow‐up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow‐up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly.

Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler – 7 January 2019 – Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis.

7 January 2019

Nadim Mahmud, David E. Kaplan, Tamar H. Taddei, David S. Goldberg – 7 January 2019 – The term acute‐on‐chronic liver failure (ACLF) is intended to identify patients with chronic liver disease who develop rapid deterioration of liver function and high short‐term mortality after an acute insult. The two prominent definitions (European Association for the Study of the Liver [EASL] and Asian Pacific Association for the Study of the Liver [APASL]) differ, and existing literature applies to narrow patient groups.

Marieke Heerkens, Suzanne Dedden, Hubertina Scheepers, Pieter Van Paassen, Ad Masclee, Christine de Die‐Smulders, Steven W.M. Olde Damink, Frank G. Schaap, Peter Jansen, Ger Koek, Ulrich Beuers, Jef Verbeek – 7 January 2019

Nashila AbdulRahim, Bekir Tanriover – 7 January 2019

Caroline C. Jadlowiec, Paige E. Morgan, Avinash K. Nehra, Matthew A. Hathcock, Walter K. Kremers, Julie K. Heimbach, Russell H. Wiesner, Timucin Taner – 7 January 2019 – T cell–mediated rejection (TCMR) is common after liver transplantation (LT), and it is often thought to have a minimum impact on outcomes. Because alloimmune response changes over time, we investigated the role of the timing of TCMR on patient and allograft survival and examined the risk factors for early and late TCMR. We reviewed protocol liver biopsies for 787 consecutive LT recipients with an 8.6‐year follow‐up.

Kazunari Sasaki, Daniel J. Firl, John C. McVey, Jesse D. Schold, Giuseppe Iuppa, Teresa Diago Uso, Masato Fujiki, Federico N. Aucejo, Cristiano Quintini, Bijan Eghetsad, Charles M. Miller, Koji Hashimoto – 7 January 2019 – A recent study using US national registry data reported, using Cox proportional hazards (PH) models, that split‐liver transplantation (SLT) has improved over time and is no more hazardous than whole‐liver transplantation (WLT). However, the study methods violated the PH assumption, which is the fundamental assumption of Cox modeling.