Lymphocyte Antigen 6 Complex, Locus C+ Monocytes and Kupffer Cells Orchestrate Liver Immune Responses Against Hepatitis B Virus in Mice

Li‐Ling Wu, Wei‐Hao Peng, Hui‐Lin Wu, Shi‐Chuen Miaw, Shiou‐Hwei Yeh, Hung‐Chih Yang, Pei‐Hsuan Liao, Jing‐Shan Lin, Yan‐Rong Chen, Yen‐Tien Hong, Hurng‐Yi Wang, Pei‐Jer Chen, Ding‐Shinn Chen – 19 January 2019 – To understand the mechanism(s) of age‐dependent outcomes of hepatitis B virus (HBV) infection in humans, we previously established an age‐related HBV mouse model in which 6‐week‐old (N6W) C3H/HeN mice exhibited virus tolerance whereas 12‐week‐old (N12W) counterparts presented virus clearance.

The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS‐9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis

Michael Trauner, Aliya Gulamhusein, Bilal Hameed, Stephen Caldwell, Mitchell L. Shiffman, Charles Landis, Bertus Eksteen, Kosh Agarwal, Andrew Muir, Simon Rushbrook, Xiaomin Lu, Jun Xu, Jen‐Chieh Chuang, Andrew N. Billin, Georgia Li, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Christopher L. Bowlus, Kris V. Kowdley – 19 January 2019 – Primary sclerosing cholangitis (PSC) represents a major unmet medical need.

Hepatology Highlights

Nicholas Russo, Arun Jesudian, Nicole T. Shen, Robert S. Brown, Akiko Sugiyama, Hayley T. Nicholls, Joseph F. Pisa, Tibor I. Krisko, Russell Rosenblatt, Zaid H. Tafesh, Brett E. Fortune, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Vikas Gupta, Tasha B. Kulai, Harmeet Malhi – 18 January 2019

Deficiency of Mitochondrial Glycerol 3‐Phosphate Dehydrogenase Contributes to Hepatic Steatosis

Yi Zheng, Hua Qu, Xin Xiong, Yuren Wang, Xiufei Liu, Linlin Zhang, Xiaoyu Liao, Qian Liao, Zheng Sun, Qin Ouyang, Gangyi Yang, Zhiming Zhu, Jing Xu, Hongting Zheng – 17 January 2019 – Mitochondrial glycerol 3‐phosphate dehydrogenase (mGPDH) is an integral component of the respiratory chain, and recent studies have suggested that it plays an important role in hepatic glucose homeostasis. However, its function in hepatic lipid metabolism is unclear. Here, we identified a role for mGPDH in nonalcoholic fatty liver disease (NAFLD).

IL‐22 and IL‐22‐Binding Protein Are Associated With Development of and Mortality From Acute‐on‐Chronic Liver Failure

Katharina Schwarzkopf, Sabrina Rüschenbaum, Samarpita Barat, Chengcong Cai, Marcus M. Mücke, Daniel Fitting, Andreas Weigert, Bernhard Brüne, Stefan Zeuzem, Christoph Welsch, Christian M. Lange – 17 January 2019 – Interleukin‐22 (IL‐22) has context‐dependent hepatoprotective or adverse properties in vitro and in animal models. IL‐22 binding protein (IL‐22BP) is a soluble inhibitor of IL‐22 signaling. The role of IL‐22 and IL‐22BP in patients with acute‐on‐chronic liver failure (ACLF) is unclear.

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