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Jianping Weng – 7 February 2019
Lack of Benefit and Potential Harm of Induction Therapy in Simultaneous Liver‐Kidney Transplants
Burcin Ekser, Chandrashekhar A. Kubal, Jonathan A. Fridell, Asif A. Sharfuddin, Tim E. Taber, Marco A. Lacerda, Marwan S. Ghabril, John A. Powelson, William C. Goggins – 7 February 2019
Damage‐Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology
Uwe Scheuermann, Minghua Zhu, Mingqing Song, John Yerxa, Qimeng Gao, Robert P. Davis, Min Zhang, William Parker, Matthew G. Hartwig, Jean Kwun, Todd V. Brennan, Jaewoo Lee, Andrew S. Barbas – 7 February 2019 – Machine preservation (MP) has emerged as a promising technology in liver transplantation, but the cellular processes occurring during MP have not been characterized. Recent studies have noted the presence of inflammatory molecules generated during MP.
Clinical Remission of Delta‐Aminolevulinic Acid Dehydratase Deficiency Through Suppression of Erythroid Heme Synthesis
Rochus A. Neeleman, Eduard J. van Beers, Edith C. Friesema, Rita Koole‐Lesuis, Willem L. van der Pol, J.H. Paul Wilson, Janneke G. Langendonk – 6 February 2019
Clinical Remission of Delta‐Aminolevulinic Acid Dehydratase Deficiency Through Suppression of Erythroid Heme Synthesis
Rochus A. Neeleman, Eduard J. van Beers, Edith C. Friesema, Rita Koole‐Lesuis, Willem L. van der Pol, J.H. Paul Wilson, Janneke G. Langendonk – 6 February 2019
No Clear Evidence for an Effect of Sofosbuvir Against Hepatitis E Virus in Organ Transplant Patients
Nassim Kamar, Qiuwei Pan – 5 February 2019
Prothrombin Complex Concentrates for Coagulopathy in Liver Disease: Single‐Center, Clinical Experience in 105 Patients
Anja Drebes, Marie de Vos, Sunita Gill, Emma Fosbury, Sue Mallett, Andy Burroughs, Banwari Agarwal, David Patch, Pratima Chowdary – 5 February 2019 – Patients with liver disease frequently develop coagulopathy, and fresh frozen plasma is traditionally used for correction of coagulopathy to manage and prevent bleeding. Prothrombin complex concentrates (PCCs) offer an attractive alternative because they are more readily available and avoid large‐volume transfusion. This retrospective, single‐center study reviewed clinical use of PCC in patients with acute/chronic liver disease.
Murine Liver Organoids as a Genetically Flexible System to Study Liver Cancer InVivo and In Vitro
Anna Saborowski, Katharina Wolff, Steffi Spielberg, Benedikt Beer, Björn Hartleben, Zulrahman Erlangga, Diana Becker, Lukas E. Dow, Silke Marhenke, Norman Woller, Kristian Unger, Peter Schirmacher, Michael P. Manns, Jens U. Marquardt, Arndt Vogel, Michael Saborowski – 5 February 2019 – The rising incidence of cholangiocarcinoma (CCA) coupled with a low 5‐year survival rate that remains below 10% delineates the urgent need for more effective treatment strategies.
Exosomal Interferon‐Induced Transmembrane Protein 2 Transmitted to Dendritic Cells Inhibits Interferon Alpha Pathway Activation and Blocks Anti–Hepatitis B Virus Efficacy of Exogenous Interferon Alpha
Ying Shi, Lingyao Du, Duoduo Lv, Hong Li, Jin Shang, Jiajie Lu, Lingyun Zhou, Lang Bai, Hong Tang – 5 February 2019 – The negative regulators in the interferon (IFN) signaling pathway inhibit intrahepatic immune response, resulting in suboptimal therapeutic response to IFNα treatment in chronic hepatitis B (CHB) patients. Identifying the key negative factors and elucidating the regulating mechanism are essential for improving anti‐HBV (hepatitis B virus) efficacy of IFNα.