Protective Function of Mitogen‐Activated Protein Kinase Phosphatase 5 in Aging‐ and Diet‐Induced Hepatic Steatosis and Steatohepatitis

Peng Tang, Heng Boon Low, Chin Wen Png, Federico Torta, Jaspal Kaur Kumar, Hwee Ying Lim, Yi Zhou, Henry Yang, Veronique Angeli, Asim Shabbir, E. Shyong Tai, Richard A. Flavell, Chen Dong, Markus R. Wenk, Dan Yock Yang, Yongliang Zhang – 1 March 2019 – Nonalcoholic fatty liver disease is currently the most common liver disease and is a leading cause of liver‐related morbidity and mortality. However, its pathogenesis remains largely unclear.

Dual Specificity Phosphatase 12 Regulates Hepatic Lipid Metabolism Through Inhibition of the Lipogenesis and Apoptosis Signal–Regulating Kinase 1 Pathways

Zhen Huang, Lei‐Ming Wu, Jie‐Lei Zhang, Abdelkarim Sabri, Shou‐Jun Wang, Gui‐Jun Qin, Chang‐Qing Guo, Hong‐Tao Wen, Bin‐Bin Du, Dian‐Hong Zhang, Ling‐Yao Kong, Xin‐Yu Tian, Rui Yao, Ya‐Peng Li, Cui Liang, Peng‐Cheng Li, Zheng Wang, Jin‐Yan Guo, Ling Li, Jian‐Zeng Dong, Yan‐Zhou Zhang – 1 March 2019 – Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease worldwide. Due to the growing economic burden of NAFLD on public health, it has become an emergent target for clinical intervention.

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