Jean‐Yves Scoazec, Gérard Feldmann – 1 September 1990 – Hepatic sinusoidal lesions, including peliosis hepatis and sinusoidal dilatation, are frequently observed during human immunodeficiency virus infection. It has been proposed that human immunodeficiency virus itself plays a role in their pathogenesis. To test this hypothesis, we attempted to determine whether liver sinusoidal cells express the CD4 molecule, which behaves as a membrane receptor mediating the binding of human immunodeficiency virus to its target cells.

Philippe Levy, Patrick Marcellin, Michèle Martinot‐Peignoux, Claude Degott, Joëlle Nataf, Jean‐Pierre Benhamou – 1 September 1990 – The purposes of this study were (a) to describe the clinical and biochemical manifestations associated with spontaneous reactivation of hepatitis B virus as defined by the reappearance of hepatitis B virus DNA in serum using dot‐blot hybridization and (b) to determine whether the clinical and biochemical manifestations associated with hepatitis B virus reactivation were different in patients with and without human immunodeficiency virus‐1 infection.

Josep M. Piqué, Pilar Pizcueta, ROSA M. Pérez Ayuso, Jaime Bosch – 1 September 1990 – Rats with chronic portal hypertension have an increased gastric mucosal blood flow and an impaired acid secretory response to pentagastrin stimulation. This study investigated the effects of propranolol, a drug widely used in the treatment of portal hypertension, on gastric mucosal blood flow and acid secretion in portal hypertensive rats with partial portal vein occlusion.

Peter R. Galle, Lorenz Theilmann, Richard Raedsch, Gerd Otto, Adolf Stiehl – 1 September 1990 – Primary human hepatocytes were used to study bile salt hepatotoxicity and the hepatoprotective potential of ursodeoxycholate in vitro. Hepatocytes were obtained by collagenase perfusion of healthy human liver tissue and were treated with glycochenodeoxycholate for 24 hr 1 day after plating. Clear signs of cytotoxicity were observed at concentrations of about 100 μmol/L glycochenodeoxycholate.

R. Shields, S. A. Jenkins – 1 September 1990

Han Moshage, Alessandro Casini, Charles S. Lieber – 1 September 1990 – Hepatocytes and fat‐storing cells have been implicated in the production of collagen, under both normal and pathological conditions. In this study, short‐term primary cultures of rat hepatocytes, maintained in a serum‐free, hormonally defined medium without dexamethasone and cultured on a fibronectin‐collagen type IV substratum, were used. Primary and passage 1 and 2 cultures of fat‐storing cells maintained on tissue culture plastic were also studied.

Harold O. Conn, Ronald L. Koretz – 1 September 1990 – Chronic hepatitis C (non‐A, non‐B hepatitis) is a common and often progressive viral liver disease. To assess the efficacy of therapy with the antiviral agent interferon alfa, we randomly assigned 166 patients with chronic hepatitis C to treatment with either 3 million or 1 million units of recombinant interferon alfa three times weekly for 24 weeks, or to no treatment.

Michael A. Gerber, Frank L. Iber – 1 September 1990

1 September 1990

Adolf Stiehl, Gerda Rudolph, Richard Raedsch, Bernd Moller, Ulrich Hopf, Erich Lotterer, Johannes Bircher, Ulrich Fölsch, Jürgen Klaus, Richard Endele, Martin Senn – 1 September 1990 – Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied.