Acetaldehyde selectively stimulates collagen production in cultured rat liver fat‐storing cells but not in hepatocytes

Han Moshage, Alessandro Casini, Charles S. Lieber – 1 September 1990 – Hepatocytes and fat‐storing cells have been implicated in the production of collagen, under both normal and pathological conditions. In this study, short‐term primary cultures of rat hepatocytes, maintained in a serum‐free, hormonally defined medium without dexamethasone and cultured on a fibronectin‐collagen type IV substratum, were used. Primary and passage 1 and 2 cultures of fat‐storing cells maintained on tissue culture plastic were also studied.

Interferon and chronic non‐A, non‐B hepatitis: Whom are we treating?

Harold O. Conn, Ronald L. Koretz – 1 September 1990 – Chronic hepatitis C (non‐A, non‐B hepatitis) is a common and often progressive viral liver disease. To assess the efficacy of therapy with the antiviral agent interferon alfa, we randomly assigned 166 patients with chronic hepatitis C to treatment with either 3 million or 1 million units of recombinant interferon alfa three times weekly for 24 weeks, or to no treatment.

Ursodeoxycholic acid–induced changes of plasma and urinary bile acids in patients with primary biliary cirrhosis

Adolf Stiehl, Gerda Rudolph, Richard Raedsch, Bernd Moller, Ulrich Hopf, Erich Lotterer, Johannes Bircher, Ulrich Fölsch, Jürgen Klaus, Richard Endele, Martin Senn – 1 September 1990 – Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied.

Pretranslational and posttranslational regulation of the EGF receptor during the prereplicative phase of liver regeneration

Staffan Johansson, Niclas Andersson, Göran Andersson – 1 September 1990 – We studied the regulation of the epidermal growth factor receptor mRNA and the number of epidermal growth factor binding sites in subcellular compartments involved in the biosynthesis and endocytosis of the epidermal growth factor receptor during the prereplicative phase of liver regeneration. The epidermal growth factor receptor mRNA, quantified by solution hybridization, decreased after partial hepatectomy, with a nadir of about 35% 18 hr after hepatectomy.

Predictive value of whole blood chemiluminescence in patients with alcoholic hepatitis

Françoise Lunel, Beatrice Descamps‐Latscha, Diane Descamps, Yves Le Charpentier, Patrick Grippon, Dominique Valla, Jean‐François Cadranel, Johannes Trum, Pierre Opolon – 1 August 1990 – Recent reports suggest that ethanol metabolism leads to reactive oxygen intermediates that may be responsible for the lesions observed in alcoholic hepatitis. This study investigated the production of reactive oxygen intermediates in peripheral blood phagocytes of patients with alcoholic hepatitis and attempts to evaluate its predictive value.

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