Prevention of hepatocyte injury and lipid peroxidation by iron chelators and α‐tocopherol in isolated iron‐loaded rat hepatocytes

Bipin K. Sharma, Bruce R. Bacon, Robert S. Britton, Chanho H. Park, Christopher J. Magiera, Rosemary O'Neill, Nicholas Dalton, Patricia Smanik, Theodore Speroff – 1 July 1990 – These experiments were performed to characterize the relationship between lipid peroxidation and hepatocyte viability in iron overload. Hepatocytes were isolated from rats with chronic dietary iron overload and the effects of in vitro iron chelation on lipid peroxidation, cell viability and ultrastructure were studied over a 4‐hr incubation period.

The demography of primary biliary cirrhosis in ontario, canada

Helga Witt‐Sullivan, Jenny Heathcote, Karen Cauch, Laurence Blendis, Cameron Ghent, Allen Katz, Ruth Milner, S. Chris Pappas, James Rankin, Ian R. Wanless – 1 July 1990 – The demographics of primary biliary cirrhosis in Ontario, Canada, are described. Two hundred and twenty‐five primary biliary cirrhosis patients were identified by 85 of 502 gastroenterologists (or internists) practicing in Ontario acute care hospitals that have 150 or more beds.

Improved survival after prophylactic portal nondecompression surgery for esophageal varices: A randomized clinical trial

Kiyoshi Inokuchi, Cooperative Study Group of Portal Hypertension of Japan – 1 July 1990 – To evaluate prophylactic surgery for esophageal varices, a prospective randomized controlled trial was begun in 1980 by the Japanese Research Society for Portal Hypertension. Methods of operation included selective shunts and nonshunting interruption procedures. One hundred and twelve Japanese patients, in whom endoscopic findings suggested risk of bleeding but who had no bleeding episode, were randomly allocated to the operated group of 60 patients or nonoperated group of 52 patients.

Hepatic expression of intercellular adhesion molecule‐1 (ICAM‐1) in viral hepatitis B

Riccardo Volpes, Joost J. van den Oord, Valeer J. Desmet – 1 July 1990 – The in situ distribution patterns of intercellular adhesion molecule‐1 and human leukocyte antigen‐DR antigens were studied in serial sections of 61 liver biopsy specimens from patients with hepatitis B virus infection using immunohistochemical techniques.

Characterization of a phenotypically and functionally distinct subset of large granular lymphocytes (pit cells) in rat liver sinusoids

Karin Vanderkerken, Luc Bouwens, Eddie Wisse – 1 July 1990 – Pit cells, or large granular lymphocytes, with natural tumoricidal activity are found in the sinusoids of normal rat liver. Hepatic large granular lymphocytes are heterogeneous and can be subdivided into two subsets. These subsets were compared with peripheralblood large granular lymphocytes and were found to differ phenotypically and functionally.

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