Louis J. Kost, Gregory J. Gores, John M. Sayles, Laurence J. Miller, John J. Lemasters, Brian Herman, Nicholas F. Larusso – 1 August 1990 – We previously reported that the liver was the major organ that extracts small, biologically active, circulating forms of cholecystokinin. Although our work indicated extensive degradation of cholecystokinin extracted from plasma during its transit across the hepatocyte, it was unclear whether cholecystokinin might also have a physiological effect on this cell before its intracellular degradation.

Nobukazu Yuki, Norio Hayashi, Akinori Kasahara, Kazuhiro Katayama, Keiji Ueda, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1990 – We have studied antibodies (anti‐pol antibody) against the polymerase gene product of hepatitis B virus by solid‐phase enzyme immunoassay using synthetic peptides coded for by this gene. Sera from six patients with acute hepatitis B, 112 chronic hepatitis B virus carriers and six healthy individuals with naturally acquired immunity to hepatitis B virus were tested for anti‐pol antibody.

Sadataka Inuzuka, Takato Ueno, Takuji Torimura, Michio Sata, Hirohiko Abe, Kyuichi Tanikawa – 1 August 1990 – The distribution of several extracellular matrix components in the liver of patients with acute viral hepatitis was studied by light and electron microscopy using indirect immunoperoxidase methods.

Hiroaki Okuda – 1 August 1990

1 August 1990

Boris Yoffe, Dennis K. Burns, Harshika S. Bhatt, Burton Combes – 1 August 1990 – Recent studies have demonstrated the presence of hepadnavirus‐related nucleic acids in extrahepatic tissues in various animal models. The prevalence and biological significance of extrahepatic infection in humans remains undetermined.

Albert Geerts, Detlef Schuppan, Sylvia Lazeroms, Ronald De Zanger, Eddie Wisse – 1 August 1990 – Collagen type I and procollagen type III were localized at the ultrastructural level on ultrathin frozen sections of rat liver by the protein A–gold technique using affinity‐purified primary antibodies. Both collagen type I and procollagen type III were localized on nearly all solitary and bundled fibrils in the space of Disse.

Michiko Nakagawa, Carla Colombo, Kenneth D. R. Setchell – 1 August 1990 – The biliary bile acid composition was determined for patients with cystic fibrosis and associated liver disease before and after the administration of ursodeoxycholic acid (10 to 15 mg/kg body wt/day). Bile acids were analyzed by fast atom bombardment ionizationmass spectrometry, high performance liquid chromatography and gas chromatography‐mass spectrometry after individual bile acids were separated according to their mode of conjugation using the lipophilic anion exchanger, diethylaminohydroxypropyl Sephadex LH‐20.

Ava Lobo‐Yeo, Giorgio Senaldi, Bernard Portmann, Alex P. Mowat, Giorgina Mieli‐Vergani, Diego Vergani – 1 August 1990 – Controversy exists regarding major histocompatibility complex antigen expression on hepatocytes. In this study, hepatocyte expression of class I and II major histocompatibility complex antigens was investigated in diseased and normal livers, using indirect immunofluorescent staining of mechanically isolated, viable hepatocytes.

Herbert L. Bonkovsky, Michael Hawkins, Karen Steinberg, Theodore Hersh, John T. Galambos, J. Michael Henderson, William J. Millikan, John R. Galloway – 1 August 1990 – To obtain information on the prevalence and clinical and laboratory correlates of osteopenia in patients with chronic liver disease, we measured bone densities and 30 selected laboratory variables in 133 subjects (70 men, 63 women) with liver disease.