Derek G. Doherty, Peter T. Donaldson, David B. Whitehouse, Giorgina Mieli‐Vergani, Ann Duthie, David A. Hopkinson, Alex P. Mowat – 1 August 1990 – Chronic liver disease affects up to 20% of children with α‐antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesis of liver damage.

1 August 1990

Martin Rossle, Wolfgang Gerok, Norman D. Grace, Harold O. Conn – 1 August 1990

Romana Lenzen, Andreas Funk, Viktoria Kolb‐Bachofen, Georg Strohmeyer – 1 August 1990 – In this study we examined the effect of pharmacological doses of various α‐adrenergic agents on hepatic portal perfusion, organic anion uptake and bile secretion using the isolated perfused rat liver. Addition of norepinephrine at portal perfusate concentrations ranging from 0.01 to 100 μmol/L induced a dose‐related increase in portal pressure with a twofold increment at the highest concentration.

Diederik K. Bosman, Nicolaas E. P. Deutz, Albert A. De Graaf, Rene W. N. Vd Hulst, Hans M. H. Van Eijk, Wim M. M. J. Bovée, Martinus A. W. Maas, George G. A. Jörning, Robert A. F. M. Chamuleau – 1 August 1990 – The effects of hyperammonemia on brain function have been studied in three different experimental models in the rat: acute liver ischemia, urease‐treated animals and methionine sulfoximine–treated animals. To quantify the development of encephalopathy, clinical grading and electroencephalographic spectral analysis were used as indicators.

T. Jake Liang, Hubert E. Blum, Jack R. Wands – 1 August 1990 – We have developed a rapid method to characterize genomic diversity of low‐level hepatitis B and related viral agents after their identification in serum by high‐affinity HBsAg‐antibody monoclonal antibody capture and subsequent polymerase chain reaction amplification. Serum from an individual with chronic liver disease and without hepatitis B virus serological markers but reactive by monoclonal antibody capture/polymerase chain reaction amplification was inoculated into a chimpanzee.

Wouter H. Lamers – 1 August 1990 – Hepatocyte age was estimated from its distance from the portal tract. We have previously shown that hepatocytes are formed adjacent to the portal tract and stream toward the terminal hepatic vein, advancing at a daily velocity of 2 μm. Thus, the farther a cell from the portal tract, the older it is. This relationship between cell age and distance served here for the study of age‐dependent changes in the hepatocyte, particularly nuclear area and DNA content.

Masao Omata – 1 August 1990

Per O. Seglen, Gunnar Sæter, Per E. Schwarze – 1 August 1990 – Cell suspensions or tissue fragments from primary hepatocellular carcinomas and benign neoplastic nodules, induced by treating rats with chemical carcinogens, were transplanted by intraportal injection or subcapsular implantation in the livers of syngeneic host rats. Both nodule and carcinoma transplants produced high numbers of hepatocellular carcinomas in the hosts 2 to 5 mo after transplantation.

Françoise Lunel, Beatrice Descamps‐Latscha, Diane Descamps, Yves Le Charpentier, Patrick Grippon, Dominique Valla, Jean‐François Cadranel, Johannes Trum, Pierre Opolon – 1 August 1990 – Recent reports suggest that ethanol metabolism leads to reactive oxygen intermediates that may be responsible for the lesions observed in alcoholic hepatitis. This study investigated the production of reactive oxygen intermediates in peripheral blood phagocytes of patients with alcoholic hepatitis and attempts to evaluate its predictive value.