1 July 1990

Helga Witt‐Sullivan, Jenny Heathcote, Karen Cauch, Laurence Blendis, Cameron Ghent, Allen Katz, Ruth Milner, S. Chris Pappas, James Rankin, Ian R. Wanless – 1 July 1990 – The demographics of primary biliary cirrhosis in Ontario, Canada, are described. Two hundred and twenty‐five primary biliary cirrhosis patients were identified by 85 of 502 gastroenterologists (or internists) practicing in Ontario acute care hospitals that have 150 or more beds.

Harold O. Conn – 1 July 1990

Kiyoshi Inokuchi, Cooperative Study Group of Portal Hypertension of Japan – 1 July 1990 – To evaluate prophylactic surgery for esophageal varices, a prospective randomized controlled trial was begun in 1980 by the Japanese Research Society for Portal Hypertension. Methods of operation included selective shunts and nonshunting interruption procedures. One hundred and twelve Japanese patients, in whom endoscopic findings suggested risk of bleeding but who had no bleeding episode, were randomly allocated to the operated group of 60 patients or nonoperated group of 52 patients.

Riccardo Volpes, Joost J. van den Oord, Valeer J. Desmet – 1 July 1990 – The in situ distribution patterns of intercellular adhesion molecule‐1 and human leukocyte antigen‐DR antigens were studied in serial sections of 61 liver biopsy specimens from patients with hepatitis B virus infection using immunohistochemical techniques.

Karin Vanderkerken, Luc Bouwens, Eddie Wisse – 1 July 1990 – Pit cells, or large granular lymphocytes, with natural tumoricidal activity are found in the sinusoids of normal rat liver. Hepatic large granular lymphocytes are heterogeneous and can be subdivided into two subsets. These subsets were compared with peripheralblood large granular lymphocytes and were found to differ phenotypically and functionally.

Abraham A. Shaked, Ronald W. Busuttil – 1 July 1990 – Auxiliary heterotopic liver transplantation is theoretically attractive because it leaves the recipient's liver in place. The surgical trauma of hepatectomy is avoided, and failure of the graft does not necessarily lead to the death of the patient or a second, emergency transplantation. Another advantage is that matching the body sizes of the donor and the recipient is not mandatory, which increases the number of possible donors. However, previous clinical results of auxiliary liver transplantation have been poor.

Patrick Marcellin, Marie‐Anne Loriot, Nathalie Boyer, Michéle Martinot‐Peignoux, Claude Degott, Françoise Degos, Maud Brandely, Bernard Lenfant, Jean‐Pierre Benhamou – 1 July 1990 – Pharmacokinetics, tolerance and biological effects of human recombinant γ‐interferon were studied in 12 patients with chronic active hepatitis B.

Carlos V. Paya, Keith E. Holley, Russell H. Wiesner, Kumaravelu Balasubramaniam, Thomas F. Smith, Mark J. Espy, Jurgen Ludwig, Kenneth P. Batts, Paul E. Hermans, Ruud A. F. Krom – 1 July 1990 – Immunostaining techniques that use a monoclonal antibody against an early cytomegalovirus antigen or a polyclonal antibody, in situ DNA hybridization and inoculation of cell cultures for the detection of cytomegalovirus from liver biopsy specimens were studied in 20 liver transplant patients with cytomegalovirus hepatitis, as defined by histological criteria.

Thierry M. Vander Borght, Luc E. Lambotte, Stanislas A. Pauwels, Charles C. Dive – 1 July 1990 – Noninvasive measurement of liver regeneration with positron emission tomography has been attempted with 11C‐thymidine; however, results were unsatisfactory using thymidine labeled on its methyl group.