Romana Lenzen, Andreas Funk, Viktoria Kolb‐Bachofen, Georg Strohmeyer – 1 August 1990 – In this study we examined the effect of pharmacological doses of various α‐adrenergic agents on hepatic portal perfusion, organic anion uptake and bile secretion using the isolated perfused rat liver. Addition of norepinephrine at portal perfusate concentrations ranging from 0.01 to 100 μmol/L induced a dose‐related increase in portal pressure with a twofold increment at the highest concentration.

Martin Rossle, Wolfgang Gerok, Norman D. Grace, Harold O. Conn – 1 August 1990

1 August 1990

Derek G. Doherty, Peter T. Donaldson, David B. Whitehouse, Giorgina Mieli‐Vergani, Ann Duthie, David A. Hopkinson, Alex P. Mowat – 1 August 1990 – Chronic liver disease affects up to 20% of children with α‐antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesis of liver damage.

Sheri M. Krams, Judy van de Water, Ross L. Coppel, Carlos Esquivel, John Roberts, Aftab Ansari, M. Eric Gershwin – 1 August 1990 – The histological findings in patients with primary biiary cirrhosis have been well‐defined and are often used in the clinical staging of disease. However, it has only been with the development of reagents that phenotypically characterize the lymphoid infiltrate that attempts have been made to correlate pathophysiology with immune effector populations.

Livio Capocaccia, Oliviero Riggio – 1 August 1990 – The beneficial effect of disaccharides, lactulose and lactitol, in prevention and treatment of hepatic encephalopathy is well established but their use in combination with neomycin is still controversial. We studied in vitro the fecal bacterial growth, acid and gas formation in presence of lactitol (beta‐galactosidesorbitol) and neomycin alone or in combination. The results indicate that neomycin only inhibits the growth of susceptible bacteria (E. coli, Staph. aureus) which, conversely, are poor lactitol fermenters.

Yun‐Fan Liaw, Dra. M. Buti – 1 August 1990

1 August 1990

Alfredo Alberti, Daniela Cavalletto, Liliana Chemello, Fabio Beluss, Giovanna Fattovich, Patrizia Pontisso, Gabriele Milanes, Arturo Ruol – 1 August 1990 – The preS1 domain of hepatitis B virus envelope proteins contains a site of attachment to the hepatocyte membrane that has been shown to evoke virusneutralizing antibodies. Using synthetic peptides, we have examined kinetics and specificity of the antibody response to preS1 during acute and chronic HBV infection.

Jean‐Pierre Villeneuve, P.‐Michel Huet, Louise Gariepy, Daphna Fenyves, Bernard Willems, Jean Cǒté, Réal Lapointe, Denis Marleau – 1 August 1990 – Cirrhotic livers obtained from eight patients who underwent orthotopic liver transplantation were perfused through the portal vein and hepatic artery in a closed recycling system for periods ranging from 2 to 7 hr. An average perfusion flow of 451 ml/min was used, with about 80% coming from the portal vein and 20% from the hepatic artery.