Michiko Nakagawa, Carla Colombo, Kenneth D. R. Setchell – 1 August 1990 – The biliary bile acid composition was determined for patients with cystic fibrosis and associated liver disease before and after the administration of ursodeoxycholic acid (10 to 15 mg/kg body wt/day). Bile acids were analyzed by fast atom bombardment ionizationmass spectrometry, high performance liquid chromatography and gas chromatography‐mass spectrometry after individual bile acids were separated according to their mode of conjugation using the lipophilic anion exchanger, diethylaminohydroxypropyl Sephadex LH‐20.

Albert Geerts, Detlef Schuppan, Sylvia Lazeroms, Ronald De Zanger, Eddie Wisse – 1 August 1990 – Collagen type I and procollagen type III were localized at the ultrastructural level on ultrathin frozen sections of rat liver by the protein A–gold technique using affinity‐purified primary antibodies. Both collagen type I and procollagen type III were localized on nearly all solitary and bundled fibrils in the space of Disse.

Boris Yoffe, Dennis K. Burns, Harshika S. Bhatt, Burton Combes – 1 August 1990 – Recent studies have demonstrated the presence of hepadnavirus‐related nucleic acids in extrahepatic tissues in various animal models. The prevalence and biological significance of extrahepatic infection in humans remains undetermined.

1 August 1990

Hiroaki Okuda – 1 August 1990

Sadataka Inuzuka, Takato Ueno, Takuji Torimura, Michio Sata, Hirohiko Abe, Kyuichi Tanikawa – 1 August 1990 – The distribution of several extracellular matrix components in the liver of patients with acute viral hepatitis was studied by light and electron microscopy using indirect immunoperoxidase methods.

Nobukazu Yuki, Norio Hayashi, Akinori Kasahara, Kazuhiro Katayama, Keiji Ueda, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1990 – We have studied antibodies (anti‐pol antibody) against the polymerase gene product of hepatitis B virus by solid‐phase enzyme immunoassay using synthetic peptides coded for by this gene. Sera from six patients with acute hepatitis B, 112 chronic hepatitis B virus carriers and six healthy individuals with naturally acquired immunity to hepatitis B virus were tested for anti‐pol antibody.

Louis J. Kost, Gregory J. Gores, John M. Sayles, Laurence J. Miller, John J. Lemasters, Brian Herman, Nicholas F. Larusso – 1 August 1990 – We previously reported that the liver was the major organ that extracts small, biologically active, circulating forms of cholecystokinin. Although our work indicated extensive degradation of cholecystokinin extracted from plasma during its transit across the hepatocyte, it was unclear whether cholecystokinin might also have a physiological effect on this cell before its intracellular degradation.

Noboru Hirooka, Yoshiro Nitta, Takabumi Tsunoda, Eiji Kitazawa, Junichi Sato, Akira Machii, Yoshitsugu Murakami, Manabu Takahashi, Fukuo Kondo – 1 August 1990 – A microscopic atypical focus suggestive of hepatocellular carcinoma is reported. The lesion, 0.3 mm in diameter, was found by chance in a liver biopsy specimen taken from a cirrhotic patient; it was characterized histologically by cytoplasmic basophilia, hypercellularity (high nucleus‐to‐cell ratio) and microacinar structures.

Fred M. Hunter – 1 August 1990