Pere Ginés, Antoni Rimola, Ramón Planas, Victor Vargas, Francesc Marco, Manuel Almela, Montserrat Forne, Maria Luisa Miranda, Josep Llach, Joan Manuel Salmerón, Maria Esteve, Josep Maria Marques, Maria Teresa Jiménez de Anta, Vicente Arroyo, Joan Rodés – 1 October 1990 – Eighty cirrhotic patients who had recovered from an episode of spontaneous bacterial peritonitis were included in a multicenter, double‐blind trial aimed at comparing long‐term norfloxacin administration (400 mg/day; 40 patients) vs. placebo (40 patients) in the prevention of spontaneous bacterial peritonitis recurrence.

Anna Mae Diehl, Suzan Abdo, Nesbitt Brown – 1 October 1990 – Biosynthesis of the polyamines, putrescine, spermidine and spermine, is required for DNA synthesis and liver regeneration after partial hepatectomy. Chronic ethanol consumption impairs polyamine synthesis during the prereplicative phase after partial hepatectomy. To determine whether this delay in polyamine synthesis contributes to ethanol's inhibition of liver regeneration, the ability of supplemental putrescine to improve regeneration in ethanol‐fed rats was tested.

Anastasios A. Mihas – 1 September 1990

Staffan Johansson, Niclas Andersson, Göran Andersson – 1 September 1990 – We studied the regulation of the epidermal growth factor receptor mRNA and the number of epidermal growth factor binding sites in subcellular compartments involved in the biosynthesis and endocytosis of the epidermal growth factor receptor during the prereplicative phase of liver regeneration. The epidermal growth factor receptor mRNA, quantified by solution hybridization, decreased after partial hepatectomy, with a nadir of about 35% 18 hr after hepatectomy.

Fuad Hasan, Lennox J. Jeffers, Maria De Medina, K. Rajender Reddy, Talley Parker, Eugene R. Schiff, Michael Houghton, Quilim Choo, George Kuo – 1 September 1990 – In the United States, a large percentage of patients with hepatocellular carcinoma are serologically negative for hepatitis B.

Adolf Stiehl, Gerda Rudolph, Richard Raedsch, Bernd Moller, Ulrich Hopf, Erich Lotterer, Johannes Bircher, Ulrich Fölsch, Jürgen Klaus, Richard Endele, Martin Senn – 1 September 1990 – Ursodeoxycholic acid treatment of patients with primary biliary cirrhosis may lead to relief of pruritus and improvement of biochemical liver tests. The changes in serum and urinary bile acids induced by ursodeoxycholic acid treatment were studied.

1 September 1990

Michael A. Gerber, Frank L. Iber – 1 September 1990

Harold O. Conn, Ronald L. Koretz – 1 September 1990 – Chronic hepatitis C (non‐A, non‐B hepatitis) is a common and often progressive viral liver disease. To assess the efficacy of therapy with the antiviral agent interferon alfa, we randomly assigned 166 patients with chronic hepatitis C to treatment with either 3 million or 1 million units of recombinant interferon alfa three times weekly for 24 weeks, or to no treatment.

Han Moshage, Alessandro Casini, Charles S. Lieber – 1 September 1990 – Hepatocytes and fat‐storing cells have been implicated in the production of collagen, under both normal and pathological conditions. In this study, short‐term primary cultures of rat hepatocytes, maintained in a serum‐free, hormonally defined medium without dexamethasone and cultured on a fibronectin‐collagen type IV substratum, were used. Primary and passage 1 and 2 cultures of fat‐storing cells maintained on tissue culture plastic were also studied.