Extrahepatic hepatitis B virus DNA sequences in patients with acute hepatitis B infection

Boris Yoffe, Dennis K. Burns, Harshika S. Bhatt, Burton Combes – 1 August 1990 – Recent studies have demonstrated the presence of hepadnavirus‐related nucleic acids in extrahepatic tissues in various animal models. The prevalence and biological significance of extrahepatic infection in humans remains undetermined.

Collagen type I and III occur together in hybrid fibrils in the space of disse of normal rat liver

Albert Geerts, Detlef Schuppan, Sylvia Lazeroms, Ronald De Zanger, Eddie Wisse – 1 August 1990 – Collagen type I and procollagen type III were localized at the ultrastructural level on ultrathin frozen sections of rat liver by the protein A–gold technique using affinity‐purified primary antibodies. Both collagen type I and procollagen type III were localized on nearly all solitary and bundled fibrils in the space of Disse.

Comprehensive study of the biliary bile acid composition of patients with cystic fibrosis and associated liver disease before and after UDCA administration

Michiko Nakagawa, Carla Colombo, Kenneth D. R. Setchell – 1 August 1990 – The biliary bile acid composition was determined for patients with cystic fibrosis and associated liver disease before and after the administration of ursodeoxycholic acid (10 to 15 mg/kg body wt/day). Bile acids were analyzed by fast atom bombardment ionizationmass spectrometry, high performance liquid chromatography and gas chromatography‐mass spectrometry after individual bile acids were separated according to their mode of conjugation using the lipophilic anion exchanger, diethylaminohydroxypropyl Sephadex LH‐20.

Class I and class II major histocompatibility complex antigen expression on hepatocytes: A study in children with liver disease

Ava Lobo‐Yeo, Giorgio Senaldi, Bernard Portmann, Alex P. Mowat, Giorgina Mieli‐Vergani, Diego Vergani – 1 August 1990 – Controversy exists regarding major histocompatibility complex antigen expression on hepatocytes. In this study, hepatocyte expression of class I and II major histocompatibility complex antigens was investigated in diseased and normal livers, using indirect immunofluorescent staining of mechanically isolated, viable hepatocytes.

Prevalence and prediction of osteopenia in chronic liver disease

Herbert L. Bonkovsky, Michael Hawkins, Karen Steinberg, Theodore Hersh, John T. Galambos, J. Michael Henderson, William J. Millikan, John R. Galloway – 1 August 1990 – To obtain information on the prevalence and clinical and laboratory correlates of osteopenia in patients with chronic liver disease, we measured bone densities and 30 selected laboratory variables in 133 subjects (70 men, 63 women) with liver disease.

Effects of putrescine on D‐galactosamine–induced acute liver failure in rats

Shuhei Nishiguchi, Tetsuo Kuroki, Tadashi Takeda, Shinya Nakajima, Susumu Shiomi, Shuichi Seki, Isao Matsui‐Yuasa, Shuzo Otani, Kenzo Kobayashi – 1 August 1990 – We studied the effects of putrescine on acute liver failure caused in rats by two injections of 1 gm/kg D‐galactosamine. The hepatic polyamine level rose only slightly in the D‐galactosamine–injected rats treated with glucagon and insulin, and [3H]thymidine incorporation into DNA increased little; these hormones did not improve the survival rate.

Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats

Rolando Hernández‐muñoz, Mauricio Díaz‐muñoz, Jorge Suárez, Victoria Chagoya de Sánchez – 1 August 1990 – Adenosine administration was tested in rats with carbon tetrachloride–induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin. This amelioration of the hepatomegaly was accompanied by a 50% reduction of the liver collagen deposition and preservation of content of glycosaminoglycans. A stimulated hepatic collagenase activity is apparently the mechanism for reduction of collagen accumulation.

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