Ellen B. Hunter, Stephen P. Powers, Louis J. Kost, Delia I. Pinon, Laurence J. Miller, Nicholas F. LaRusso – 1 July 1990 – Although the liver is known to extract amino acids and organic anions by well‐characterized transport systems, the factors that regulate the hepatic uptake of small, circulating peptides are poorly understood. We previously reported that cholecystokinin octapeptide, a biologically active form of cholecystokinin, is efficiently cleared by the liver and that uptake depends on its carboxyl‐terminal tetrapeptide (Trp‐Met‐Asp‐PheNH2).

William P. J. Leenders, Harrie L. Glansbeek, Wieke C. C. De Bruin, Sing‐Hiem Yap – 1 July 1990 – A likely mechanism of the strong hepatotrophism of the hepatitis B virus is the presence of specific receptors for the surface antigen of hepatitis B virus on hepatocyte membranes. To examine this hypothesis, we have performed binding studies using recombinant large (preS1 + preS2 + S) and major (S) proteins with adult human hepatocytes, rat hepatocytes, human fibroblasts, human peripheral blood mononuclear cells and plasma membranes derived from these cell types.

Janna Collins, Sidney Goldfischer – 1 July 1990 – A clinicopathologic picture of severe neonatal liver disease associated with heavy stainable iron stores in a “hemochromatotic” distribution has been designated as neonatal or perinatal iron storage disease or hemochromatosis.

Gioacchino Leandro, M. G. Brook, P. Karayiannis, H. C. Thomas – 1 July 1990

Kim M. Summers, June W. Halliday, Lawrie W. Powell – 1 July 1990 – The value of measurement of hepatic iron concentration and determination of the hepatic iron index in distinguishing homozygotes from heterozygotes for hemochromatosis was examined. The study group included 42 homozygotes with an unequivocal diagnosis of hemochromatosis and six individuals who had initial equivocal results but were established as homozygous after extensive follow‐up.

Irene D. Roman, Maria J. Monte, Jose M. Gonzalez‐Buitrago, Alejandro Esteller, Rafael Jiménez – 1 July 1990 – In an attempt to understand the hepatotoxicity associated with immunosuppressive therapy with cyclosporin A, we investigated the effects of acute cyclosporin A administration on biliary secretion, serum bile acid and bilirubin levels and the histological changes in the hepatic parenchyma in anesthetized male Wistar rats.

Michael Manns, Ulrich Zanger, Guido Gerken, Kevin F. Sullivan, Karl‐H. Meyer Zum Büschenfelde, Urs A. Meyer, Michel Eichelbaum – 1 July 1990 – Liver‐kidney microsomal‐1 autoantibodies characterize a subgroup of autoimmune chronic active hepatitis. The liver antigen of liver‐kidney microsomal‐1 antibodies has been identified as cytochrome P450 db1, a microsomal enzyme catalyzing the oxidative metabolism of more than 20 drugs, including debrisoquine, sparteine and bufuralol.

Michael A. Gerber, Sanda Clejan – 1 July 1990

John Olynyk, Pauline Hall, Richard Sallie, William Reed, Keith Shilkin, Malcolm Mackinnon – 1 July 1990 – The measurement of stainable hepatic iron using a microcomputer image analysis system was compared with standard biochemical measurements of liver iron content in 103 liver biopsy specimens–29 of idiopathic hemochromatosis, 51 of alcoholic liver disease and 23 of various nonalcoholic liver diseases. Sections were stained using Perls' method for iron; the mean area staining positively for iron was measured and expressed as a percentage of the area of biopsy measured.

Stephen A. Geller, W. Stephen Nichols, Mark J. Dycaico, Katherine A. Felts, Joseph A. Sorge – 1 July 1990 – Transgenic mice were constructed using human α1‐antitrypsin M and Z genomic clones. Livers of the M lineage mice showed slight cellular pleomorphism and immunohistochemically demonstrable finely granular α1‐antitrypsin material in hepatocytes. Z lineage mice with five gene copies per haploid mouse genome (Z # 1) demonstrated fine granular α1‐antitrypsin material and a few large globules.