Christine Challen, John Lunec, William Warren, Jane Collier, Margaret F. Bassendine – 1 December 1992 – Human hepatocellular carcinomas from patients in Britain, an area of low prevalence of hepatocellular carcinoma and low dietary exposure to aflatoxin B1, were analyzed for mutations in the p53 tumorsuppressor gene. Abnormalities in the p53 gene were detected in 2 of 19 hepatocellular carcinomas by polymerase chain reaction—single‐stranded conformation polymorphism.

Hiroshi Adachi, Shuichi Kaneko, Eiki Matsushita, Yutaka Inagaki, Masashi Unoura, Kenichi Kobayashi – 1 December 1992 – The natural history of chronic hepatitis B patients who spontaneously cleared serum HBsAg was investigated. A total of 351 patients with chronic hepatitis B were observed in our hospital for at least 3 yr. Seven of these patients became HBsAg negative during the follow‐up period. HBsAg disappeared within 6 mo (range = 11 to 169 days, mean = 70 days) after acute elevation of ALT.

Pierre Laurent‐Puig, Jean‐François Flejou, Monique Fabre, Pierre Bedossa, Jacques Belghiti, François Gayral, Dominique Franco – 1 November 1992 – Mutant p53 has been found in a wide variety of human malignancies including carcinomas of the lung, breast and colon.

Antonio Francavilla, Alessandro Azzarone, Guiseppe Carrieri, Carlo Scotti‐Fogueni, Qia‐Hua Zeng, Umberto Cillo, Kendrick Porter, Thomas E. Starzl – 1 November 1992 – Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula.

Yoshihide Ishiki, Hiroo Ohnishi, Yasutoshi Muto, Kunio Matsumoto, Toshikazu Nakamura – 1 November 1992 – Hepatocyte growth factor, a potent mitogen for mature hepatocytes in vitro, seems to function as a hepatotrophic factor for liver regeneration. We examined the mitogenic effect of hepatocyte growth factor on mouse liver in vivo.

Henry C. Bodenheimer – 1 November 1992

Eugene R. Schiff – 1 November 1992

Russell H. Wiesner, Michael K. Porayko, E. Rolland Dickson, Gregory J. Gores, Nicholas F. Larusso, J. Eileen Hay, H. Erik Wahlstrom, Ruud A. F. Krom – 1 November 1992

Robert Cywes, Paul D. Greig, Glynn R. Morgan, Juan R. Sanabria, Pierre‐Alain Clavien, P. Robert C. Harvey, Steven M. Strasberg – 1 November 1992 – Organ donors are typically subject to acute hyponutrition that might affect postpreservation liver function. Livers from nutritionally supplemented rats function better after preservation than livers from fasted rats. We have developed a method to glycogenate the liver of large animals in the temporal context of a human donor liver operation and have studied the fate of glycogen stores during preservation.

Masaaki Masuhara, Sikandar L. Katyal, Toshikazu Nakamura, Hisashi Shinozuka – 1 November 1992 – Hepatocyte growth factor, a potent hepatocyte mitogen in vitro, appears to trigger hepatocyte regeneration after partial hepatectomy and after acute liver cell necrosis. Transforming growth factor‐α and transforming growth factor‐β may also be involved in the control of liver regeneration.