Ascitic fluid acidosis in bacterial peritonitis: A poor prognostic sign?

Norman Gitlin – 1 May 1990 – The aim of this retrospective study was to define prognostic factors for cure and survival after spontaneous bacterial peritonitis. In a 4‐year period from 1982 to 1986, spontaneous bacterial peritonitis wasdiagnosed in 38 consecutive hospitalized cirrhotic patients (positive ascites culture and polymorphonuclear cell concentrations greater than 250 cells per mm3). Twenty‐five patients recovered from their infection (69 p. 100) in a mean time of 9 ± 7 days. The cumulative survival was 68 p. 100 at one week, 50 p. 100 at one month, and 25 p. 100 at one year.

α‐fetoprotein in the woodchuck model of hepadnavirus infection and disease: Immunochemical analysis of woodchuck α‐fetoprotein and measurement in serum by quantitative monoclonal radioimmunoassay

Paul J. Cote, Christoph Pohl, Juanell Boyd, Bud C. Tennant, John L. Gerin – 1 May 1990 – Woodchuck hepatitis virus infection of the eastern woodchuck represents a useful model for the study of hepatitis B virus infection and disease in humans, including hepatocellular carcinoma. In man, hepatocellular carcinoma is frequently detected and monitored using assays for serum alpha‐fetoprotein.

Sjögren's syndrome in patients with primary biliary cirrhosis

Epaminondas V. Tsianos, Jay H. Hoofnagle, Philip C. Fox, Margaret Alspaugh, E. Anthony Jones, Daniel F. Schafer, Haralampos M. Moutsopoulos – 1 May 1990 – Symptomatology and objective findings of Sjögren's syndrome were evaluated in 38 consecutive patients with primary biliary cirrhosis. Symptoms of Sjögren's syndrome were present in 18 (47.4%) patients, but were severe enough to warrant therapy in only four (10.5%).

Variable expression of preS1 antigen in serum during chronic hepatitis B virus infection: An accurate marker for the level of hepatitis B virus replication

Marie‐Anne Petit, Fabien Zoulim, Francis Caipel, Sylvie Dubanchet, Charles Dauguet, Christina Trepo – 1 May 1990 – The expression of the preSl antigen of hepatitis B virus in sera from chronic HBsAg carriers was studied using a specific monoclonal antibody F35.25 in an original, double‐immunoradiometric assay. The antibody F35.25 recognized an epitope located between amino‐acid residues 32 and 53 on the preSl sequence of the large HBsAg protein. This domain could be involved in the recognition of hepatitis B virus by hepatocyte receptors.

micronodular transpormation (nodular regenerative hyperplasia) of the liver: A report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules

Ian R. Wanless – 1 May 1990 – Nodular regenerative hyperplasia is defined by he‐patocellular nodules distributed throughout the liver in the absence of fibrous septa between the nodules. Most reports have been single cases so that the prevalencend clinical significance of nodular regenerative hyperplasia is uncertain. In this study, the hepatic histology of 2,500 consecutive autopsies was reviewed.

Phenobarbital influences the development of sodium retention in liver disease induced by bile duct ligation in the rat

Georg Wensing, Robert A. Branch – 1 May 1990 – The onset of sodium retention in phenobarbital/carbon tetrachloride‐induced cirrhosis in rats is preceded by a linear decrease in hepatic function as assessed by the aminopyrine rate constant of elimination. Sodium retention occurs when liver function decreases below a critical aminopyrine rate constant of elimination threshold of 1 min− × 10−3.

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