Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: A comparison of two rodent models of fulminant liver failure

Margaret S. Swain, Marcelle Bergeron, Robert Audet, Andres T. Bleiz, Roger F. Butterworth – 1 October 1992 – Alterations of brain and cerebrospinal fluid amino acids have consistently been described in human and experimental fulminant liver failure.

Two distinct subtypes of hepatitis C virus defined by antibodies directed to the putative core protein

Atsuhiko Machida, Hitoshi Ohnuma, Fumio Tsuda, Eisuke Munekata, Takeshi Tanaka, Yoshihiro Akahane, Hiroaki Okamoto, Shunji Mishiro – 1 October 1992 – Four distinct genotypes of hepatitis C virus types I, II, III and IV have been identified by comparison of nucleotide sequences of isolates from different areas of the world. We examined the possibility that hepatitis C virus may have serologically definable subtypes. Enzyme‐linked immunosorbent assay systems were prepared by use of two synthetic peptides deduced from the putative core protein of hepatitis C virus.

Metabolic clearance rate of arginine vasopressin in patients with cirrhosi

José A. Solis‐Herruzo, Amelia Gonzalez‐Gamarra, Gregorio Castellano, Maria Teresa Muñoz‐yagüe – 1 October 1992 – Metabolic clearance rate and half‐time of arginine vasopressin were measured in 43 cirrhotic patients and 10 control subjects. Synthetic arginine vasopressin was infused intravenously at a rate of 500 pg/min/kg of body weight for 75 min.

31P magnetic resonance spectroscopy detects a functional abnormality in liver metabolism after acetaminophen poisoning

Ruth M. Dixon, Peter W. Angus, Bheeshma Rajagopalan, George K. Radda – 1 October 1992 – Eighteen patients with acetaminophen poisoning were studied with 31P magnetic resonance spectroscopy to measure phosphorus‐containing metabolites in their livers. The concentrations of all magnetic resonance—detectable metabolites fell in parallel with a decrease in the synthetic ability of the liver, indicated by the prothrombin time ratio (international normalized ratio).

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