Glucuronidation of oxazepam is not spared in patients with hepatic encephalopathy
Jesper Sonne, Per Buch Andreasen, Steffen Loft, Martin Døsing, Frederik Andreasen – 1 June 1990 – The disposition of oral oxazepam was investigated in seven patients with decompensated cirrhosis and encephalopathy and in nine healthy individuals to further examine the hypothesis of preservation of glucuronidation in liver disease. The patients showed a severe reduction in the quantitative liver function as assessed by estimation of the clearance of antipyrine; the median value was 9 ml. min−1 and the range was 6 to 12 ml. min−1.