Gioacchino Leandro, M. G. Brook, P. Karayiannis, H. C. Thomas – 1 July 1990

Kim M. Summers, June W. Halliday, Lawrie W. Powell – 1 July 1990 – The value of measurement of hepatic iron concentration and determination of the hepatic iron index in distinguishing homozygotes from heterozygotes for hemochromatosis was examined. The study group included 42 homozygotes with an unequivocal diagnosis of hemochromatosis and six individuals who had initial equivocal results but were established as homozygous after extensive follow‐up.

Irene D. Roman, Maria J. Monte, Jose M. Gonzalez‐Buitrago, Alejandro Esteller, Rafael Jiménez – 1 July 1990 – In an attempt to understand the hepatotoxicity associated with immunosuppressive therapy with cyclosporin A, we investigated the effects of acute cyclosporin A administration on biliary secretion, serum bile acid and bilirubin levels and the histological changes in the hepatic parenchyma in anesthetized male Wistar rats.

Michael Manns, Ulrich Zanger, Guido Gerken, Kevin F. Sullivan, Karl‐H. Meyer Zum Büschenfelde, Urs A. Meyer, Michel Eichelbaum – 1 July 1990 – Liver‐kidney microsomal‐1 autoantibodies characterize a subgroup of autoimmune chronic active hepatitis. The liver antigen of liver‐kidney microsomal‐1 antibodies has been identified as cytochrome P450 db1, a microsomal enzyme catalyzing the oxidative metabolism of more than 20 drugs, including debrisoquine, sparteine and bufuralol.

Michael A. Gerber, Sanda Clejan – 1 July 1990

John Olynyk, Pauline Hall, Richard Sallie, William Reed, Keith Shilkin, Malcolm Mackinnon – 1 July 1990 – The measurement of stainable hepatic iron using a microcomputer image analysis system was compared with standard biochemical measurements of liver iron content in 103 liver biopsy specimens–29 of idiopathic hemochromatosis, 51 of alcoholic liver disease and 23 of various nonalcoholic liver diseases. Sections were stained using Perls' method for iron; the mean area staining positively for iron was measured and expressed as a percentage of the area of biopsy measured.

Stephen A. Geller, W. Stephen Nichols, Mark J. Dycaico, Katherine A. Felts, Joseph A. Sorge – 1 July 1990 – Transgenic mice were constructed using human α1‐antitrypsin M and Z genomic clones. Livers of the M lineage mice showed slight cellular pleomorphism and immunohistochemically demonstrable finely granular α1‐antitrypsin material in hepatocytes. Z lineage mice with five gene copies per haploid mouse genome (Z # 1) demonstrated fine granular α1‐antitrypsin material and a few large globules.

Manuela Merli, Oliviero Riggio, Adriana Romiti, Franco Ariosto, Lucio Mango, Giorgio Pinto, Massimiliano Savioli, Livio Capocaccia – 1 July 1990 – The basal energy production rate was measured using indirect calorimetry in 25 stable cirrhotic patients and 10 controls of comparable age. The endogenous substrate oxidation was also calculated by measuring urinary nitrogen excretion. The energy production rate was similar in cirrhotic patients and controls. The origins of liver disease and the degree of liver damage did not seem to influence the energy production rate.

Thierry M. Vander Borght, Luc E. Lambotte, Stanislas A. Pauwels, Charles C. Dive – 1 July 1990 – Noninvasive measurement of liver regeneration with positron emission tomography has been attempted with 11C‐thymidine; however, results were unsatisfactory using thymidine labeled on its methyl group.

Carlos V. Paya, Keith E. Holley, Russell H. Wiesner, Kumaravelu Balasubramaniam, Thomas F. Smith, Mark J. Espy, Jurgen Ludwig, Kenneth P. Batts, Paul E. Hermans, Ruud A. F. Krom – 1 July 1990 – Immunostaining techniques that use a monoclonal antibody against an early cytomegalovirus antigen or a polyclonal antibody, in situ DNA hybridization and inoculation of cell cultures for the detection of cytomegalovirus from liver biopsy specimens were studied in 20 liver transplant patients with cytomegalovirus hepatitis, as defined by histological criteria.